Translation of mRNA injected into Xenopus oocytes is specifically inhibited by antisense RNA.

The bacteriophage SP6 promoter and RNA polymerase were used to synthesize sense and antisense RNAs coding for the enzymes thymidine kinase (TK) and chloramphenicol acetyl transferase (CAT). Injection of antisense CAT RNA into frog oocytes inhibited expression of sense CAT mRNA. Similarly, antisense TK RNA inhibited expression of sense TK mRNA. Antisense RNAs were stable in oocytes and had no detectable effect on either the expression of endogenous proteins or on the expression of nonhomologous RNA transcripts. CAT activity expressed from a plasmid transcribed in the oocyte nucleus was also inhibited by antisense RNA injected into the oocyte cytoplasm. The data suggest that antisense RNA will be useful in identifying the function of specific mRNA sequences during early development of the frog

Bounding the CRRA Utility Functions

The constant-relative-risk-aversion (CRRA) utility function is now predominantly used in quantitative macroeconomic studies. This function, however, is not bounded and thus creates problems when applying the standard tools of dynamic programming. This paper devises a method for "bounding" the CRRA utility functions. The proposed method is based on a set of conditions that can establish boundedness among a broad class of utility functions. These results are then used to construct a bounded utility function that is identical to a CRRA utility function except when consumption is very small or very large. It is shown that the constructed utility function also satisfies the Inada condition and is consistent with balanced growth.Utility Function; Elasticity of Marginal Utility; Boundedness

Learning and memory in machines and animals : an AI model that accounts for some neurobiological data

The CEL model of learning and memory (Components of Episodic Learning) [Granger 1982, 1983a, 1983b] provides a process model of certain aspects of learning and memory in animals and humans. The model consists of a set of asynchronous and semi-independent functional operators that collectively create and modify memory traces as a result of experience. The model conforms to relevant results in the learning literature of psychology and neurobiology. There are two goals to this work: one is to create a set of working learning systems that will improve their performance on the basis of experience, and the other is to compare these systems' performance with that of living systems, as a step towards the eventual comparative characterizations of different learning systems.Parts of the model have been implemented in the CEL-0 program, which operates in a 'Maze-World' simulated maze environment. The program exhibits simple exploratory behavior that leads to the acquisition of predictive and discriminatory schemata. A number of interesting theoretical predictions have arisen in part from observation of the operation of the program, some of which are currently being tested in neurobiological experiments. In particular, some neurobiological evidence for the existence of multiple, seperable memory systems in humans and animals is interpreted in terms of the model, and some new experiments are suggested arising from the model's predictions

The infra-red spectrum and molecular structure of HNCS

From an examination of the microwave spectra of four isotopic species of isothiocyanic acid, Beard and Dailey (1) recently obtained the following values for the molecular parameters in the ground vibrational state

Bounding the CRRA Utility Functions

The constant-relative-risk-aversion (CRRA) utility function is now predominantly used in quantitative macroeconomic studies. This function, however, is not bounded and thus creates problems when applying the standard tools of dynamic programming. This paper devises a method for "bounding" the CRRA utility functions. The proposed method is based on a set of conditions that can establish boundedness among a broad class of utility functions. These results are then used to construct a bounded utility function that is identical to a CRRA utility function except when consumption is very small or very large. It is shown that the constructed utility function also satisfies the Inada condition and is consistent with balanced growth.Utility Function; Elasticity of Marginal Utility; Boundedness

High frequency and high wavenumber solar oscillations

We determine the frequencies of solar oscillations covering a wide range of degree (100< l <4000) and frequency (1.5 <\nu<10 mHz) using the ring diagram technique applied to power spectra obtained from MDI (Michelson Doppler Imager) data. The f-mode ridge extends up to degree of approximately 3000, where the line width becomes very large, implying a damping time which is comparable to the time period. The frequencies of high degree f-modes are significantly different from those given by the simple dispersion relation \omega^2=gk. The f-mode peaks in power spectra are distinctly asymmetric and use of asymmetric profile increases the fitted frequency bringing them closer to the frequencies computed for a solar model.Comment: Revised version. 1.2 mHz features identified as artifacts of data analysis. Accepted for publication in Ap

EXODUS: Integrating intelligent systems for launch operations support

Kennedy Space Center (KSC) is developing knowledge-based systems to automate critical operations functions for the space shuttle fleet. Intelligent systems will monitor vehicle and ground support subsystems for anomalies, assist in isolating and managing faults, and plan and schedule shuttle operations activities. These applications are being developed independently of one another, using different representation schemes, reasoning and control models, and hardware platforms. KSC has recently initiated the EXODUS project to integrate these stand alone applications into a unified, coordinated intelligent operations support system. EXODUS will be constructed using SOCIAL, a tool for developing distributed intelligent systems. EXODUS, SOCIAL, and initial prototyping efforts using SOCIAL to integrate and coordinate selected EXODUS applications are described