The White Dwarf Cooling Sequence of NGC6397

We present the results of a deep Hubble Space Telescope (HST) exposure of the nearby globular cluster NGC6397, focussing attention on the cluster's white dwarf cooling sequence. This sequence is shown to extend over 5 magnitudes in depth, with an apparent cutoff at magnitude F814W=27.6. We demonstrate, using both artificial star tests and the detectability of background galaxies at fainter magnitudes, that the cutoff is real and represents the truncation of the white dwarf luminosity function in this cluster. We perform a detailed comparison between cooling models and the observed distribution of white dwarfs in colour and magnitude, taking into account uncertainties in distance, extinction, white dwarf mass, progenitor lifetimes, binarity and cooling model uncertainties. After marginalising over these variables, we obtain values for the cluster distance modulus and age of \mu_0 = 12.02 \pm 0.06 and T_c = 11.47 \pm 0.47Gyr (95% confidence limits). Our inferred distance and white dwarf initial-final mass relations are in good agreement with other independent determinations, and the cluster age is consistent with, but more precise than, prior determinations made using the main sequence turnoff method. In particular, within the context of the currently accepted \Lambda CDM cosmological model, this age places the formation of NGC6397 at a redshift z=3, at a time when the cosmological star formation rate was approaching its peak.Comment: 56 pages, 30 figure

The Space Motion of the Globular Cluster NGC 6397

As a by-product of high-precision, ultra-deep stellar photometry in the Galactic globular cluster NGC 6397 with the Hubble Space Telescope, we are able to measure a large population of background galaxies whose images are nearly point-like. These provide an extragalactic reference frame of unprecedented accuracy, relative to which we measure the most accurate absolute proper motion ever determined for a globular cluster. We find mu_alpha = 3.56 +/- 0.04 mas/yr and mu_delta = -17.34 +/- 0.04 mas/yr. We note that the formal statistical errors quoted for the proper motion of NGC 6397 do not include possible unavoidable sources of systematic errors, such as cluster rotation. These are very unlikely to exceed a few percent. We use this new proper motion to calculate NGC 6397's UVW space velocity and its orbit around the Milky Way, and find that the cluster has made frequent passages through the Galactic disk.Comment: 5 pages including 3 figures, accepted for publication in the Astrophysical Journal Letters. Very minor changes in V2. typos fixe

The Stellar Content of M31's Bulge

In this paper we analyze the stellar populations present in M31 using nine sets of adjacent HST-NICMOS Camera 1 and 2 fields with galactocentric distances ranging from 2' to 20'. These infrared observations provide some of the highest spatial resolution measurements of M31 to date; our data place tight constraints on the maximum luminosities of stars in the bulge of M31. The tip of the red giant branch is clearly visible at Mbol ~ -3.8, and the tip of the asymptotic giant branch (AGB) extends to Mbol ~ -5. This AGB peak luminosity is significantly fainter than previously claimed; through direct comparisons and simulations we show that previous measurements were affected by image blending. We do observe field-to-field variations in the luminosity functions, but simulations show that these differences can be produced by blending in the higher surface brightness fields. We conclude that the red giant branch of the bulge of M31 is not measurably different from that of the Milky Way's bulge. We also find an unusually high number of bright blueish stars (7.3/arcmin^2) which appear to be Galactic foreground stars.Comment: 28 pages, 20 figures (posted here with significantly reduced resolution), accepted to the A

Stellar Proper Motions in the Galactic Bulge from deep HST ACS/WFC Photometry

We present stellar proper motions in the Galactic bulge from the Sagittarius Window Eclipsing Extrasolar Search (SWEEPS) project using ACS/WFC on HST. Proper motions are extracted for more than 180,000 objects, with >81,000 measured to accuracy better than 0.3 mas/yr in both coordinates. We report several results based on these measurements: 1. Kinematic separation of bulge from disk allows a sample of >15,000 bulge objects to be extracted based on >6-sigma detections of proper motion, with <0.2% contamination from the disk. This includes the first detection of a candidate bulge Blue Straggler population. 2. Armed with a photometric distance modulus on a star by star basis, and using the large number of stars with high-quality proper motion measurements to overcome intrinsic scatter, we dissect the kinematic properties of the bulge as a function of distance along the line of sight. This allows us to extract the stellar circular speed curve from proper motions alone, which we compare with the circular speed curve obtained from radial velocities. 3. We trace the variation of the {l,b} velocity ellipse as a function of depth. 4. Finally, we use the density-weighted {l,b} proper motion ellipse produced from the tracer stars to assess the kinematic membership of the sixteen transiting planet candidates discovered in the Sagittarius Window; the kinematic distribution of the planet candidates is consistent with that of the disk and bulge stellar populations.Comment: 71 pages, 30 figures, ApJ Accepte

Deep ACS Imaging in the Globular Cluster NGC 6397: The Cluster Color Magnitude Diagram and Luminosity Function

We present the CMD from deep HST imaging in the globular cluster NGC 6397. The ACS was used for 126 orbits to image a single field in two colors (F814W, F606W) 5 arcmin SE of the cluster center. The field observed overlaps that of archival WFPC2 data from 1994 and 1997 which were used to proper motion (PM) clean the data. Applying the PM corrections produces a remarkably clean CMD which reveals a number of features never seen before in a globular cluster CMD. In our field, the main sequence stars appeared to terminate close to the location in the CMD of the hydrogen-burning limit predicted by two independent sets of stellar evolution models. The faintest observed main sequence stars are about a magnitude fainter than the least luminous metal-poor field halo stars known, suggesting that the lowest luminosity halo stars still await discovery. At the bright end the data extend beyond the main sequence turnoff to well up the giant branch. A populous white dwarf cooling sequence is also seen in the cluster CMD. The most dramatic features of the cooling sequence are its turn to the blue at faint magnitudes as well as an apparent truncation near F814W = 28. The cluster luminosity and mass functions were derived, stretching from the turn off down to the hydrogen-burning limit. It was well modeled with either a very flat power-law or a lognormal function. In order to interpret these fits more fully we compared them with similar functions in the cluster core and with a full N-body model of NGC 6397 finding satisfactory agreement between the model predictions and the data. This exercise demonstrates the important role and the effect that dynamics has played in altering the cluster IMF.Comment: 43 pages including 4 tables and 12 diagrams. Figures 2 and 3 have been bitmapped. Accepted for publication in the Astronomical Journa

Deep ACS Imaging in the Globular Cluster NGC6397: Dynamical Models

We present N-body models to complement deep imaging of the metal-poor core-collapsed cluster NGC6397 obtained with the Hubble Space Telescope. All simulations include stellar and binary evolution in-step with the stellar dynamics and account for the tidal field of the Galaxy. We focus on the results of a simulation that began with 100000 objects (stars and binaries), 5% primordial binaries and Population II metallicity. After 16 Gyr of evolution the model cluster has about 20% of the stars remaining and has reached core-collapse. We compare the color-magnitude diagrams of the model at this age for the central region and an outer region corresponding to the observed field of NGC6397 (about 2-3 half-light radii from the cluster centre). This demonstrates that the white dwarf population in the outer region has suffered little modification from dynamical processes - contamination of the luminosity function by binaries and white dwarfs with non-standard evolution histories is minimal and should not significantly affect measurement of the cluster age. We also show that the binary fraction of main-sequence stars observed in the NGC6397 field can be taken as representative of the primordial binary fraction of the cluster. For the mass function of the main-sequence stars we find that although this has been altered significantly by dynamics over the cluster lifetime, especially in the central and outer regions, that the position of the observed field is close to optimal for recovering the initial mass function of the cluster stars (below the current turn-off mass). More generally we look at how the mass function changes with radius in a dynamically evolved stellar cluster and suggest where the best radial position to observe the initial mass function is for clusters of any age.Comment: 34 pages, 11 figures, submitted to AJ, companion paper to 0708.403

Probing the Faintest Stars in a Globular Star Cluster

NGC 6397 is the second closest globular star cluster to the Sun. Using 5 days of time on the Hubble Space Telescope, we have constructed the deepest ever color-magnitude diagram for this cluster. We see a clear truncation in each of its two major stellar sequences. Faint red main sequence stars run out well above our observational limit and near to the theoretical prediction for the lowest mass stars capable of stable hydrogen-burning in their cores. We also see a truncation in the number counts of faint blue stars, namely white dwarfs. This reflects the limit to which the bulk of the white dwarfs can cool over the lifetime of the cluster. There is also a turn towards bluer colors in the least luminous of these objects. This was predicted for the very coolest white dwarfs with hydrogen-rich atmospheres as the formation of H2 causes their atmospheres to become largely opaque to infrared radiation due to collision-induced absorption.Comment: 12 pages, 4 figures. Full Resolution Figures in Science, 2006, 313, 93

Care-Related Risk Factors for Hospital-Acquired Pressure Ulcers in Elderly Adults with Hip Fracture

To identify care-related factors associated with increased incidence of hospital-acquired pressure ulcers (HAPU

Direct In Vivo Evidence for Tumor Propagation by Glioblastoma Cancer Stem Cells

High-grade gliomas (World Health Organization grade III anaplastic astrocytoma and grade IV glioblastoma multiforme), the most prevalent primary malignant brain tumors, display a cellular hierarchy with self-renewing, tumorigenic cancer stem cells (CSCs) at the apex. While the CSC hypothesis has been an attractive model to describe many aspects of tumor behavior, it remains controversial due to unresolved issues including the use of ex vivo analyses with differential growth conditions. A CSC population has been confirmed in malignant gliomas by preferential tumor formation from cells directly isolated from patient biopsy specimens. However, direct comparison of multiple tumor cell populations with analysis of the resulting phenotypes of each population within a representative tumor environment has not been clearly described. To directly test the relative tumorigenic potential of CSCs and non-stem tumor cells in the same microenvironment, we interrogated matched tumor populations purified from a primary human tumor transplanted into a xenograft mouse model and monitored competitive in vivo tumor growth studies using serial in vivo intravital microscopy. While CSCs were a small minority of the initial transplanted cancer cell population, the CSCs, not the non-stem tumor cells, drove tumor formation and yielded tumors displaying a cellular hierarchy. In the resulting tumors, a fraction of the initial transplanted CSCs maintained expression of stem cell and proliferation markers, which were significantly higher compared to the non-stem tumor cell population and demonstrated that CSCs generated cellular heterogeneity within the tumor. These head-to-head comparisons between matched CSCs and non-stem tumor cells provide the first functional evidence using live imaging that in the same microenvironment, CSCs more than non-stem tumor cells are responsible for tumor propagation, confirming the functional definition of a CSC