666 research outputs found
Ceftaroline Fosamil for Treatment of Pediatric Complicated Skin and Soft Tissue Infections and Community-Acquired Pneumonia
Community-acquired pneumonia (CAP)/community-acquired bacterial pneumonia (CABP) and complicated skin and soft tissue infection (cSSTI)/acute bacterial skin and skin structure infection (ABSSSI) represent major causes of morbidity and mortality in children. ÎČ-Lactams are the cornerstone of antibiotic treatment for many serious bacterial infections in children; however, most of these agents have no activity against methicillin-resistant Staphylococcus aureus (MRSA). Ceftaroline fosamil, a ÎČ-lactam with broad-spectrum in vitro activity against Gram-positive pathogens (including MRSA and multidrug-resistant Streptococcus pneumoniae) and common Gram-negative organisms, is approved in the European Union and the United States for children with CAP/CABP or cSSTI/ABSSSI. Ceftaroline fosamil has completed a pediatric investigation plan including safety, efficacy, and pharmacokinetic evaluations in patients with ages ranging from birth to 17 years. It has demonstrated similar clinical and microbiological efficacy to best available existing treatments in phase IIIâIV trials in patients aged â„ 2 months to < 18 years with CABP or ABSSSI, with a safety profile consistent with the cephalosporin class. It is also approved in the European Union for neonates with CAP or cSSTI, and in the US for neonates with ABSSSI. Ceftaroline fosamil dosing for children (including renal function adjustments) is supported by pharmacokinetic/pharmacodynamic modeling and simulations in appropriate age groups, and includes the option of 5- to 60-min intravenous infusions for standard doses, and a high dose for cSSTI patients with MRSA isolates, with a ceftaroline minimum inhibitory concentration of 2â4 mg/L. Considered together, these data suggest ceftaroline fosamil may be beneficial in the management of CAP/CABP and cSSTI/ABSSSI in children
Time Scales in Spectator Fragmentation
Proton-proton correlations and correlations of p-alpha, d-alpha, and t-alpha
from spectator decays following Au + Au collisions at 1000 AMeV have been
measured with an highly efficient detector hodoscope. The constructed
correlation functions indicate a moderate expansion and low breakup densities
similar to assumptions made in statistical multifragmentation models. In
agreement with a volume breakup rather short time scales were deduced employing
directional cuts in proton-proton correlations.
PACS numbers: 25.70.Pq, 21.65.+f, 25.70.MnComment: 8 pages, with 5 included figures; To appear in the proceedings of the
CRIS 2000 conference; Also available from
http://www-kp3.gsi.de/www/kp3/aladin_publications.htm
Breakup Density in Spectator Fragmentation
Proton-proton correlations and correlations of protons, deuterons and tritons
with alpha particles from spectator decays following 197Au + 197Au collisions
at 1000 MeV per nucleon have been measured with two highly efficient detector
hodoscopes. The constructed correlation functions, interpreted within the
approximation of a simultaneous volume decay, indicate a moderate expansion and
low breakup densities, similar to assumptions made in statistical
multifragmentation models.
PACS numbers: 25.70.Pq, 21.65.+f, 25.70.Mn, 25.75.GzComment: 11 pages, LaTeX with 3 included figures; Also available from
http://www-kp3.gsi.de/www/kp3/aladin_publications.htm
Thermal and Chemical Freeze-out in Spectator Fragmentation
Isotope temperatures from double ratios of hydrogen, helium, lithium,
beryllium, and carbon isotopic yields, and excited-state temperatures from
yield ratios of particle-unstable resonances in 4He, 5Li, and 8Be, were
determined for spectator fragmentation, following collisions of 197Au with
targets ranging from C to Au at incident energies of 600 and 1000 MeV per
nucleon. A deviation of the isotopic from the excited-state temperatures is
observed which coincides with the transition from residue formation to
multi-fragment production, suggesting a chemical freeze-out prior to thermal
freeze-out in bulk disintegrations.Comment: 14 pages, 10 figures, submitted to Phys. Rev. C, small changes as
suggested by the editors and referee
The Particle Physics Reach of High-Energy Neutrino Astronomy
We discuss the prospects for high-energy neutrino astronomy to study particle
physics in the energy regime comparable to and beyond that obtainable at the
current and planned colliders. We describe the various signatures of
high-energy cosmic neutrinos expected in both neutrino telescopes and air
shower experiments and discuss these measurements within the context of
theoretical models with a quantum gravity or string scale near a TeV,
supersymmetry and scenarios with interactions induced by electroweak
instantons. We attempt to access the particle physics reach of these
experiments.Comment: Mini-review article for New Journal of Physics, "Focus on Neutrinos"
issue. 27 pages, 11 figure
Temperatures of Exploding Nuclei
Breakup temperatures in central collisions of 197Au + 197Au at bombarding
energies E/A = 50 to 200 MeV were determined with two methods. Isotope
temperatures, deduced from double ratios of hydrogen, helium, and lithium
isotopic yields, increase monotonically with bombarding energy from 5 MeV to 12
MeV, in qualitative agreement with a scenario of chemical freeze-out after
adiabatic expansion. Excited-state temperatures, derived from yield ratios of
states in 4He, 5Li, 6Li, and 8Be, are about 5 MeV, independent of the
projectile energy, and seem to reflect the internal temperature of fragments at
their final separation from the system.
PACS numbers: 25.70.Mn, 25.70.Pq, 25.75.-qComment: 10 pages, RevTeX with 4 included figures; Also available from
http://www-kp3.gsi.de/www/kp3/aladin_publications.htm
The Antares Collaboration : Contributions to the 34th International Cosmic Ray Conference (ICRC 2015, The Hague)
The ANTARES detector, completed in 2008, is the largest neutrino telescope in the Northern hemisphere. Located at a depth of 2.5 km in the Mediterranean Sea, 40 km off the Toulon shore, its main goal is the search for astrophysical high energy neutrinos. In this paper we collect the 21 contributions of the ANTARES collaboration to the 34th International Cosmic Ray Conference (ICRC 2015). The scientific output is very rich and the contributions included in these proceedings cover the main physics results, ranging from steady point sources, diffuse searches, multi-messenger analyses to exotic physics
All-sky Search for High-Energy Neutrinos from Gravitational Wave Event GW170104 with the ANTARES Neutrino Telescope
Advanced LIGO detected a significant gravitational wave signal (GW170104)
originating from the coalescence of two black holes during the second
observation run on January 4, 2017. An all-sky high-energy
neutrino follow-up search has been made using data from the ANTARES neutrino
telescope, including both upgoing and downgoing events in two separate
analyses. No neutrino candidates were found within s around the GW
event time nor any time clustering of events over an extended time window of
months. The non-detection is used to constrain isotropic-equivalent
high-energy neutrino emission from GW170104 to less than
erg for a spectrum
The ANTARES Collaboration: Contributions to ICRC 2017 Part I: Neutrino astronomy (diffuse fluxes and point sources)
Papers on neutrino astronomy (diffuse fluxes and point sources, prepared for
the 35th International Cosmic Ray Conference (ICRC 2017, Busan, South Korea) by
the ANTARES Collaboratio
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