Online prevention of postpartum depression for Spanish- and English-speaking pregnant women: A pilot randomized controlled trial

AbstractBackgroundPostpartum depression (PPD) is a maternal mental health problem that affects women from all regions of the world. Unfortunately, even in developed countries, half of the cases go undetected and, consequently, untreated. Individuals from low and middle income countries trend toward underutilization of mental health services, partly due to the limited number of available psychological resources. The primary aims of this pilot randomized controlled trial were to adapt to the Internet using the Mothers and Babies Course/Curso Mamás y Bebés, a prevention of PPD intervention, to describe the characteristics of the pregnant women who engaged in the intervention site, and to obtain preliminary data on the efficacy of the Internet intervention to reduce the risk of PPD.MethodsPregnant women, 18years or older who were interested in using the site for themselves were recruited and randomly assigned to a fully-automated self-help Internet intervention or to an information-only control condition. Randomized participants were invited to complete monthly depression assessments up to six months postpartum. To examine the prevention effects of the Internet intervention, pregnant women who did not meet current criteria for a major depressive episode, who engaged with the study website, and who provided depression data during the postpartum follow-up period were included in the study analyses.ResultsParticipants were 111 predominantly Spanish-speaking (82.9%) and Latino/Hispanic (71.3%) pregnant women residing in 23 countries worldwide. The effect of the prevention intervention condition failed to reach significance at the a priori alpha-level. However, the observed coefficient trended in the hypothesized direction (b=−0.514, χ2 (1)=3.43, p=.061; HR=0.598). The benefits of receiving the e-MB Internet intervention were greater for pregnant women reporting high (vs. low) levels of prenatal depression symptoms (b=−0.605, χ2 (1)=5.20, p=.023).ConclusionsThis study provides preliminary evidence that Internet interventions are a promising method toward expanding the reach of psychological resources to perinatal women at-risk for PPD

Unifying gauge couplings at the string scale

Using the current precision electroweak data, we look for the minimal particle content which is necessary to add to the standard model in order to have a complete unification of gauge couplings and gravity at the weakly coupled heterotic string scale. We find that the addition of a vector-like fermion at an intermediate scale and a non-standard hypercharge normalization are in general sufficient to achieve this goal at two-loop level. Requiring the extra matter scale to be below the TeV scale, it is found that the addition of three vector-like fermion doublets with a mass around 700 GeV yields a perfect string-scale unification, provided that the affine levels are $(k_Y, k_2 ,k_3)=(13/3, 1, 2)$, as in the $SU(5) \times SU(5)$ string-GUT. Furthermore, if supersymmetry is broken at the unification scale, the Higgs mass is predicted in the range 125 GeV - 170 GeV, depending on the precise values of the top quark mass and $\tan \beta$ parameter.Comment: 11 pages, 4 eps figures, using jpconf style, talk given at CORFU2005, RTN meeting ``The Quest for Unification: Theory Confronts Experiment'', 11 - 18 September 2005, Corfu, Greec

Internet interventions for improving psychological well‐being in psycho‐oncology: review and recommendations

Objective Too few cancer patients and survivors receive evidence‐based interventions for mental health symptoms. This review examines the potential for Internet interventions to help fill treatment gaps in psychosocial oncology and presents evidence regarding the likely utility of Internet interventions for cancer patients. Methods The authors examined available literature regarding Internet interventions tailored to cancer patients' mental health needs and reviewed elements of Internet interventions for mental health relevant to advancing psycho‐oncology Internet intervention research. Results Few rigorous studies focusing on mental health of cancer patients have been conducted online. A growing body of evidence supports the efficacy, accessibility, and acceptability of mental health Internet interventions for a variety of general and medical patient populations. The authors present recommendations and guidelines to assist researchers in developing, testing, and disseminating Internet interventions for cancer patients and survivors, to manage and improve their mental health. Issues unique to Internet interventions—including intervention structure, customization, provider interaction, and privacy and confidentiality issues—are discussed. These guidelines are offered as a step toward establishing a set of “best practices” for Internet interventions in psycho‐oncology and to generate further discussion regarding the goals of such interventions and their place in cancer care. Conclusions Internet interventions have the potential to fill an important gap in quality cancer care by augmenting limited available mental health services. These interventions should be developed in a manner consistent with best practices and must be empirically tested and validated. Copyright © 2011 John Wiley & Sons, Ltd.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/93546/1/pon1993.pd

Brief Report: Adapted Cognitive Behavioral Group Therapy for Depressed Low-Income African American Women

In this study we examine the degree to which a manualized cognitive-behavioral therapy intervention can be adapted to be culturally sensitive in treating depressed low-income African American women with multiple stressors. We describe the adaptations we made to an existing intervention, a group treatment developed for depressed low-income medical patients. We also describe our evaluation of the adapted treatment in which outcomes of African American women treated in the culturally adapted group were compared to African American women treated in the non-adapted group. Following treatment, women in the adapted group exhibited a larger drop in average BDI scores. Implications are discussed in terms of challenges related to the development and evaluation of culturally adapted treatment.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44312/1/10597_2004_Article_453616.pd

Surface atmospheric circulation patterns and associated minimum temperatures in the Maipo and Casablanca valleys, central Chile

Abstract This paper analyzes the influence of circulation anomalies on the magnitude of minimum air temperature (T min ) at a daily scale in two important agricultural valleys of Chile (Maipo and Casablanca) during the period [2001][2002][2003][2004][2005][2006][2007]. A statistical classification of synoptic fields was performed, resulting in eight circulation patterns (CPs, 84 % of explained variance). The corresponding anomalies of T min (AT min ) of each CP were analyzed in order to understand their synoptic-scale forcing mechanisms. Results showed a direct association between AT min and the synoptic structure. The average weakening in sea level pressure (SLP) yields positive AT min , while negative AT min is associated with a strengthening in SLP. In the latter case, it was also found that a synoptic structure (10.2 % of frequency) corresponding to a migratory high-pressure system passing eastward across the Andes led to the lowest AT min and a higher probability of frost in both valleys (22 % on average) in winter and springtime

Factors associated with smoking in low-income persons with and without chronic illness

INTRODUCTION Tobacco disparities persist among low-income smokers who seek care from safety-net clinics. Many of these patients suffer from chronic illnesses (CILs) that are associated with and exacerbated by smoking. The objective of the current study was to examine the differences between safety-net patients with and without CILs in terms of nicotine dependence and related factors (such as depression, anxiety) and self-efficacy regarding ability to abstain from smoking. METHODS Sixty-four low-income smokers who thought about or intended to quit smoking were recruited from the San Francisco Health Network (SFHN) and assessed for CILs, nicotine dependence, depression, anxiety, and smoking abstinence self-efficacy. Four one-way analyses of variance were used to examine the difference between those with and without CIL on the latter four variables. RESULTS The CIL group had significantly higher anxiety (CIL: 8.0 ± 5.35; non-CIL: 4.44 ± 3.48; p=0.02) and tended to have higher nicotine dependence (CIL: 5.40 ± 2.58; non-CIL: 3.88 ± 2.28; p=0.04). In the CIL group, nicotine dependence was positively correlated with anxiety [r(62)=0.39; p\u3c0.01] and negatively correlated with smoking abstinence self-efficacy [r(62)= -0.38; p\u3c0.01]. Both depression (Spearman’s rho=0.39; p\u3c0.01) and anxiety (Spearman’s rho=0.29; p\u3c0.05) were associated with total number of CIL categories. CONCLUSIONS Safety-net patients who smoke and suffer from CILs may be suffering from higher levels of anxiety and have less confidence in their ability to quit smoking. Incorporating mood management and developing interventions that increase a sense of self-efficacy for refraining from smoking may be necessary to help low-income smokers quit smoking

Multi-partner Demonstration of BGPLS enabled multi-domain EON control and instantiation with H-PCE

The control of multidomain elastic optical networks (EONs) is possible by combining Hierarchical Path Computation Element (H-PCE)-based computation, Border Gateway Protocol with Extensions for Traffic Engineering Link State Information (BGP-LS) topology discovery, remote instantiation via Path Computation Element Communication Protocol (PCEP), and signaling via Resource Reservation Protocol with Extensions for Traffic Engineering (RSVP-TE). Two evolutionary architectures are considered, one based on stateless H-PCE, PCEP instantiation, and end-to-end RSVP-TE signaling (SL-E2E), and a second one based on stateful active H-PCE with per-domain instantiation and stitching. This paper presents the first multiplatform demonstration that fully validates both control architectures achieving multiprotocol interoperability. SL-E2E leads to slightly faster provisioning but needs to keep the state of the stitching of the end-to-end label-switched paths in the parent PCE

The four serotypes of dengue recognize the same putative receptors in Aedes aegypti midgut and Ae. albopictus cells

BACKGROUND: Dengue viruses (DENV) attach to the host cell surface and subsequently enter the cell by receptor-mediated endocytosis. Several primary and low affinity co-receptors for this flavivirus have been identified. However, the presence of these binding molecules on the cell surface does not necessarily render the cell susceptible to infection. Determination of which of them serve as bona fide receptors for this virus in the vector may be relevant to treating DENV infection and in designing control strategies. RESULTS: (1) Overlay protein binding assay showed two proteins with molecular masses of 80 and 67 kDa (R80 and R67). (2) Specific antibodies against these two proteins inhibited cell binding and infection. (3) Both proteins were bound by all four serotypes of dengue virus. (4) R80 and R67 were purified by affinity chromatography from Ae. aegypti mosquito midguts and from Ae albopictus C6/36 cells. (5) In addition, a protein with molecular mass of 57 kDa was purified by affinity chromatography from the midgut extracts. (6) R80 and R67 from radiolabeled surface membrane proteins of C6/36 cells were immunoprecipitated by antibodies against Ae. aegypti midgut. CONCLUSION: Our results strongly suggest that R67 and R80 are receptors for the four serotypes of dengue virus in the midgut cells of Ae. aegypti and in C6/36 Ae. albopictus cells

Psychological interventions to prevent the onset of depressive disorders: A meta-analysis of randomized controlled trials

Purpose: Depressive disorders are common and have a considerable impact on patients and societies. Several treatments are available, but their effects are modest and reduce the burden only to a limited extent. Preventing the onset of depressive disorders may be one option to further reduce the global disease burden. Methods: We conducted a meta-analysis of randomized controlled trials in participants without a diagnosis of depression at baseline, who were assigned to a preventive psychological intervention, or a care-as-usual, or comparable control group and in which incident cases of depression at follow-up were ascertained with a diagnostic interview. Results: Our systematic searches resulted in 50 trials (14,665 participants) with relatively high quality, in high risk groups of all ages. The psychological interventions were mostly based on cognitive behavioral interventions. One year after the preventive interventions, the relative risk of developing a depressive disorder was RR = 0.81 (95% CI: 0.72–0.91), indicating that those who had received the intervention had 19% less chance to develop a depressive disorder. Given the average control event rate of 30%, twenty-one people had to participate in the intervention to prevent one depressive disorder compared to people in the control conditions. Conclusions: Prevention is a promising approach to reduce the global disease burden of depression in addition to treatments