Participation of young people in online social communities: an exploration of attitudes among university students in a case study in Spain

This study aims to examine the different dimensions of online citizen participation for the purpose of delving into the types of engagement that are being developed in order for citizens to benefit from the opportunities offered by the Internet. A self-administered survey has been carried out with 420 students from a Spanish public University (Universidad Rey Juan Carlos) from its five campuses in Madrid. A typology of attitudes has been developed, firstly with factor analysis, and then with a varimax rotation. Moreover, a hierarchical linear regression has been applied in order to discover the variables that might predict the typology of participation. The study shows that online participation is a complex phenomenon influenced by multiple personal and social factors. The results have revealed three points of view: 1. Scepticism toward the ability to exert influence; 2. Social networks as a channel for maintaining social contact and expressing opinions; and 3. Capability of empowering users. Certain attitudes toward social networks can predict online participatory behaviour in different types of profiles on these networks. Furthermore, age does not affect online participation, and gender only has an influence on sports and media profiles

Parameterization of the Construction Promoter\u27s Responsibilities throughout the project\u27s life cycle

Europe, and especially Spain has been suffering an ongoing economic, social and political crisis. The construction industry sector has been one of the most affected. Project Management professionals in the construction industry are obliged to make a critical analysis of their results and methodology applications used in recent years. In this paper a methodology has been developed for parameterization and monitoring of projects, portfolios and programs from both the public or private Construction Promoter\u27s point of view -the real engine of the project-. This methodology analyses their responsibilities and those of the stakeholders throughout the project\u27s lifecycle, and allows the Promoter to make decisions based on accurate, realistic and factual knowledge. The project\u27s full data is completely accessible by the Promoter. Thus the Promoter is able to develop a Project Portfolio Management and Business Intelligence. The Next step in the methodology evolution is transferring it to an ICT tool, for a promoter\u27s systematic application. Project management will assist in providing a social improvement, this method is associated with current social demands at all levels and sectors -Transparency- thus allowing realtime monitoring of the building project\u27s status throughout all stages of the project\u27s life cycle

Guía para la elaboración de Biofermento utilizados como fertilizante foliar

La Universidad de El Salvador (Facultad Multidisciplinaria Paracentral) por medio de los estudiantes de Ingeniería Agroindustrial en coordinación con la Alcaldía del municipio de Verapaz y el Centro de Tecnología Agropecuaria y Forestal (CENTA), sede Verapaz, con el fin de contribuir a la producción agrícola de manera sostenible en sus comunidades, desarrollaron la guía para la elaboración de biofermentos utilizados como fertilizante foliar, con información básica, producto de la experiencia vivida con el personal técnico de la institución y los agricultores, de igual manera con el intercambio y conocimientos de otras instituciones que generan bibliografía consultada. El CENTA elabora documentos técnicos que permite apoyar a los agricultores, facilitando la producción y el manejo de sus cultivos considerando las condiciones económicas y agroecológicas. la guía para la elaboración de biofermentos utilizados como fertilizante foliar ha sido realizada con el propósito de proporcionar una herramienta accesible a los agricultores, estudiantes y profesionales, de tal manera que sirva de información de apoyo y aprendizaje realizando aportes al proceso y desarrollo agrícola de los campesinos de nuestro paí

A Comparative Study of Owner, Contractor, and Consultant Perspective on the Selection Criteria for Subcontractors.

Up till now, most research on the selection of subcontractors in construction projects has focused on the factors considered by the main (general) contractors. The goal of this study is to identify the factors that other main stakeholders, namely clients and consultants, believe should be taken into account when selecting subcontractors. The paper presents the results of a survey of experts from various backgrounds in the construction industry and conducts a comparative study of their perspectives in factors that should be considered in selecting subcontractors. The results of the survey show that there are similarities and dissimilarities between perceptions of respondents with different background. For example, nearly all the respondents identified subcontractor’s past experience in similar projects and subcontractor’s available resources, as the most important factors that should be considered in selecting subcontractors. However, while respondents from contractor organizations identified the lowest bid as one of the most important factors, those from consultant and client organizations identified subcontractor’s safety record, compliance with project schedule, and safety programs and past safety record as their top considerations in selecting subcontractors. The paper provides an extensive statistical analysis to identify the impact of stakeholder’s background on their perspective in the importance of factors that should be considered in selecting subcontractors and discusses the similarities and dissimilarities in their perspectives

Ecosystem services of tropical dry forests : insights from longterm ecological and social research on the Pacific coast of Mexico

In the search for an integrated understanding of the relationships among productive activities, human well-being, and ecosystem functioning, we evaluated the services delivered by a tropical dry forest (TDF) ecosystem in the Chamela Region, on the Pacific Coast of Mexico. We synthesized information gathered for the past two decades as part of a long-term ecosystem research study and included social data collected in the past four years using the Millennium Ecosystem Assessment (MA) conceptual framework as a guide. Here we identify the four nested spatial scales at which information has been obtained and emphasize one of them through a basin conceptual model. We then articulate the biophysical and socio-economic constraints and drivers determining the delivery of ecosystem services in the Region. We describe the nine most important services, the stakeholders who benefit from those services, and their degree of awareness of such services. We characterize spatial and temporal patterns of the services&rsquo; delivery as well as trade-offs among services and stakeholders. Finally, we contrast three alternative future scenarios on the delivery of ecosystem services and human well-being. Biophysical and socioeconomic features of the study site strongly influence human&minus;ecosystem interactions, the ecosystem services delivered, the possible future trajectories of the ecosystem, and the effect on human well-being. We discuss future research approaches that will set the basis for an integrated understanding of human&minus;ecosystem interactions and for constructing sustainable management strategies for the TDF.<br /

Real-life disease monitoring in follicular lymphoma patients using liquid biopsy ultra-deep sequencing and PET/CT

In the present study, we screened 84 Follicular Lymphoma patients for somatic mutations suitable as liquid biopsy MRD biomarkers using a targeted next-generation sequencing (NGS) panel. We found trackable mutations in 95% of the lymph node samples and 80% of the liquid biopsy baseline samples. Then, we used an ultra-deep sequencing approach with 2 · 10−4 sensitivity (LiqBio-MRD) to track those mutations on 151 follow-up liquid biopsy samples from 54 treated patients. Positive LiqBio-MRD at first-line therapy correlated with a higher risk of progression both at the interim evaluation (HRINT 11.0, 95% CI 2.10–57.7, p = 0.005) and at the end of treatment (HREOT, HR 19.1, 95% CI 4.10–89.4, p < 0.001). Similar results were observed by PET/CT Deauville score, with a median PFS of 19 months vs. NR (p < 0.001) at the interim and 13 months vs. NR (p < 0.001) at EOT. LiqBio-MRD and PET/CT combined identified the patients that progressed in less than two years with 88% sensitivity and 100% specificity. Our results demonstrate that LiqBio-MRD is a robust and non-invasive approach, complementary to metabolic imaging, for identifying FL patients at high risk of failure during the treatment and should be considered in future response-adapted clinical trials.This study has been funded by Instituto de Salud Carlos III (ISCIII) and co-funded by the European Union through the projects PI21/00314, PI19/01430, PI19/01518 and PI18/00295, PTQ2020-011372, CP19/00140, CP22/00082, Doctorado industrial CAM IND2020/TIC-17402 and CRIS cancer foundation

La clase práctica interactiva como herramienta para optimizar la coordinación de los grupos en asignaturas prácticas del ámbito universitario

Los elementos digitales virtuales nos permiten economizar el tiempo y puede facilitar la comunicación y coordinación del alumnado con su docente, tanto en condiciones de pandemia como en condiciones de normalidad. Para este fin se generó una herramienta novedosa basada en una hoja de cálculo, con actualización instantánea en red, para el registro de las anotaciones del alumno en las prácticas de la asignatura de Optometría II de la Facultad de Óptica y Optometría de la Universidad Complutense de Madrid. El objetivo principal fue incrementar la eficiencia de las clases prácticas a través de la aplicación de recursos educativos innovadores en abierto implementando metodologías de enseñanza virtual para reducir el contacto directo entre los participantes en las clases presenciales. Esta metodología de trabajo permitió ahorrar un 50% del tiempo para llevar a cabo las actividades prácticas de los alumnos

Inmunonutrición perioperatoria. Consenso de la Asociación Colombiana de Nutrición Clínica

Immunonutrition is an alternative for surgical&nbsp;patients due to its clinical advantages. The aim is to unify the concepts&nbsp;and develop a document of easy access and quick consultation&nbsp;about immunonutrition use in surgical patients in Colombia.La inmunonutrición es una alternativa en pacientes&nbsp;quirúrgicos por sus ventajas clínicas. Se pretende unificar&nbsp;conceptos y desarrollar un documento de acceso y consulta&nbsp;fácil en relación con el uso de inmunonutrición en pacientes&nbsp;quirúrgicos en Colombia

NGS-Based Molecular Karyotyping of Multiple Myeloma: Results from the GEM12 Clinical Trial

Simple Summary Multiple Myeloma (MM) is considered an incurable chronic disease, which prognosis depends on the presence of different genomic alterations. To accomplish a complete molecular diagnosis in a single essay, we have designed and validated a capture-based NGS approach to reliably identify pathogenic mutations (SNVs and indels), genomic alterations (CNVs and chromosomic translocations), and IGH rearrangements. We have observed a good correlation of the results obtained using our capture panel with data obtained by both FISH and WES techniques. In this study, the molecular classification performed using our approach was significantly associated with the stratification and outcome of MM patients. Additionally, this panel has been proven to detect specific IGH rearrangements that could be used as biomarkers in patient follow-ups through minimal residual disease (MRD) assays. In conclusion, we think that MM patients could benefit from the use of this capture-based NGS approach with a more accurate, single-essay molecular diagnosis. Next-generation sequencing (NGS) has greatly improved our ability to detect the genomic aberrations occurring in multiple myeloma (MM); however, its transfer to routine clinical labs and its validation in clinical trials remains to be established. We designed a capture-based NGS targeted panel to identify, in a single assay, known genetic alterations for the prognostic stratification of MM. The NGS panel was designed for the simultaneous study of single nucleotide and copy number variations, insertions and deletions, chromosomal translocations and V(D)J rearrangements. The panel was validated using a cohort of 149 MM patients enrolled in the GEM2012MENOS65 clinical trial. The results showed great global accuracy, with positive and negative predictive values close to 90% when compared with available data from fluorescence in situ hybridization and whole-exome sequencing. While the treatments used in the clinical trial showed high efficacy, patients defined as high-risk by the panel had shorter progression-free survival (p = 0.0015). As expected, the mutational status of TP53 was significant in predicting patient outcomes (p = 0.021). The NGS panel also efficiently detected clonal IGH rearrangements in 81% of patients. In conclusion, molecular karyotyping using a targeted NGS panel can identify relevant prognostic chromosomal abnormalities and translocations for the clinical management of MM patients