Prevalence of malignant tumors of the head and neck region in infant and juvenile patients [Prevalência de tumores malignos infanto-juvenil de região de cabeça e pescoço]

Made available in DSpace on 2019-09-12T16:26:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2010Objective: To verify the prevalence of malignant tumors of the head and neck region in infant and juvenile patients registered at the Cancer Hospital of Pernambuco, Recife, PE, Brazil. Method: This study was a retrospective and cross-sectional investigation in which 126 patient records were reviewed between 1995 and 2000. Information on the variables gender, age group, primary anatomic localization and histological type was recorded and transcribed to a specific chart. The data were analyzed using the Statistical Package for Social Sciences (SPSS) software, version 13.0. Results: 23 cases (18.3%) were malignant tumors affecting the head and neck region of children and adolescents. The age range was between 2 and 17 years (mean age 13 years), and most patients were aged 13 to 18 years (65.2%). There was a predominance of male patients (65.2%), with a male-to- female ratio of 1.8:1. The nasopharynx was the most affected anatomic region (21.7%), followed by the parotid gland and oral cavity (17.4%). The most frequent histological types were those derived from the epithelial lineage (48%), among which the undifferentiated carcinoma (13%). Among the tumors derived from the mesenchymal tissue, the most frequent were rhabdomyosarcoma (30%) and lymphoma (17%). Conclusion: Research on infant and juvenile cancer in Brazil address the population basis and the mortality in a general manner. Data on the prevalence of malignant tumors of the head and neck region in children and adolescents are still scarce. Further studies on this area should be encouraged because they are important in the elaboration and planning of national or regional public policies and health programs.de Melo, A.U.C., Disciplina de Estomatologia, Da Universidade Tiradentes (UNIT), Aracaju/SE, BrazilValente, R.O.H., Cirurgião Buco-Maxilo-Facial do Centro, Instituto Materno Infantil de Pernambuco (IMIP), Recife/PE, BrazilMartorelli, S.B.F., Disciplina de Cirurgia e Traumatologia Buco-Maxilo-Facial, Faculdade de Odontologia do Recife (FOR), Recife/PE, BrazilRibeiro, C.F., Universidade Taubaté (UNITAU), Taubaté/SP, Brazilda Rosa, M.R.D., Departamento de Clínica e Odontologia Social, Universidade Federal da Paraíba (UFPB), João Pessoa/PB, Brazi

The extrapituitary prolactin promoter polymorphism is associated with rheumatoid arthritis and anti-CCP antibodies in Mexican population

Background and objective: Women with multiple sclerosis (MS) who intend to get pregnant are often advised to discontinue disease modifying therapy (DMT) prior to conception. This recommendation is not based on medical evidence and may interfere with disease control by immunomodulatory drugs. The present study was designed to help discuss the effect of DMT for MS on pregnancy and on disease course. Patients and methods: Retrospective data from 152 pregnancies of 132 women with MS were collected by the physician in charge of the case. All data were entered into a specific file for qualitative and quantitative statistical analysis. Results: From the total group of patients, 89 pregnancies occurred without any exposure to MS drugs, while 61 pregnancies occurred with at least eight weeks of exposure to MS immunomodulatory drugs. The rate of obstetric and neonatal complications was similar in both groups, except for the newborn weight and height which was smaller for mothers receiving medications. Mothers' post-delivery relapse rate and EDSS scores in the follow-up period were significantly higher in the absence of treatment. Conclusion: It is possible that, with further such supportive data, international guidelines on MS treatment in young women who intend to get pregnant may need to be revised. " 2012 Elsevier B.V.",,,,,,"10.1016/j.clineuro.2012.04.024",,,"http://hdl.handle.net/20.500.12104/45105","http://www.scopus.com/inward/record.url?eid=2-s2.0-84872295057&partnerID=40&md5=c20df0b7feedea45f4a1222a90afb6b2",,,,,,"2",,"Clinical Neurology and Neurosurgery",,"15

The effects of long-term exposure to disease-modifying drugs during pregnancy in multiple sclerosis

Background and objective: Women with multiple sclerosis (MS) who intend to get pregnant are often advised to discontinue disease modifying therapy (DMT) prior to conception. This recommendation is not based on medical evidence and may interfere with disease control by immunomodulatory drugs. The present study was designed to help discuss the effect of DMT for MS on pregnancy and on disease course. Patients and methods: Retrospective data from 152 pregnancies of 132 women with MS were collected by the physician in charge of the case. All data were entered into a specific file for qualitative and quantitative statistical analysis. Results: From the total group of patients, 89 pregnancies occurred without any exposure to MS drugs, while 61 pregnancies occurred with at least eight weeks of exposure to MS immunomodulatory drugs. The rate of obstetric and neonatal complications was similar in both groups, except for the newborn weight and height which was smaller for mothers receiving medications. Mothers' post-delivery relapse rate and EDSS scores in the follow-up period were significantly higher in the absence of treatment. Conclusion: It is possible that, with further such supportive data, international guidelines on MS treatment in young women who intend to get pregnant may need to be revised. © 2012 Elsevier B.V

Multiple Sclerosis In South America: Month Of Birth In Different Latitudes Does Not Seem To Interfere With The Prevalence Or Progression Of The Disease [esclerose Múltipla Na América Do Sul: Mês De Nascimento Em Diferentes Latitudes Não Parece Interferir Com A Prevalência Ou Progressão Da Doença]

Objective: To assess whether the month of birth in different latitudes of South America might influence the presence or severity of multiple sclerosis (MS) later in life. Methods: Neurologists in four South American countries working at MS units collected data on their patients' month of birth, gender, age, and disease progression. Results: Analysis of data from 1207 MS patients and 1207 control subjects did not show any significant variation in the month of birth regarding the prevalence of MS in four latitude bands (0-10; 11-20; 21-30; and 31-40 degrees). There was no relationship between the month of birth and the severity of disease in each latitude band. Conclusion: The results from this study show that MS patients born to mothers who were pregnant at different Southern latitudes do not follow the seasonal pattern observed at high Northern latitudes.719:00 AM573579Templer, D.I., Trent, N.H., Spencer, D.A., Season of birth in multiple sclerosis (1992) Acta Neurol Scand, 85, pp. 107-109Bharanidharan, P., Monthly distribution of multiple sclerosis patients' births (1997) Int J Biometeorol, 40, pp. 117-118Salemi, G., Ragonese, P., Aridon, P., Is season of birth associated with multiple sclerosis? (2000) Acta Neurol Scand, 101, pp. 381-383Salzer, J., Svenningsson, A., Sundström, P., Season of birth and multiple sclerosis in Sweden (2010) Acta Neurol Scand, 122, pp. 70-73Bayes, H.K., Weir, C.J., O'Leary, C., Timing of birth and risk of multiple sclerosis in the Scottish population (2010) Eur Neur, 63, pp. 36-40Saastamoinen, K.P., Auvinen, M.K., Tienari, P.J., Month of birth is associated with multiple sclerosis but not with HLA-DR15 in Finland (2012) Mult Scler, 18, pp. 563-568Fernandes de Abreu, D.A., Babron, M.C., Rebeix, I., Season of birth and not vitamin D receptor promoter polymorphisms is a risk factor for multiple sclerosis (2009) Mult Scler, 15, pp. 1146-1152Willer, C.J., Dyment, D.A., Sadovnick, A.D., Timing of birth and risk of multiple sclerosis: Population based study (2005) BMJ, 330, p. 120. , Canadian Collaborative Study GroupDeussing, E.C., Jankosky, C.J., Clark, L.L., Estimated incidence of multiple sclerosis among United States Armed Forces personnel using the Defense Medical Surveillance System (2012) Mil Med, 177, pp. 594-600Staples, J., Ponsonby, A.L., Lim, L., Low maternal exposure to ultraviolet radiation in pregnancy, month of birth, and risk of multiple sclerosis in offspring: Longitudinal analysis (2010) BMJ, 340, p. 1640Givon, U., Zeilig, G., Dolev, M., The month of birth and the incidence of multiple sclerosis in the Israeli population (2012) Neuroepidemiology, 38, pp. 64-68Fragoso, Y.D., Shearer, K.D., Adoni, T., Month of birth does not seem to interfere with the development of multiple sclerosis later in life in Brazilian patients (2012) Neuroepidemiology, 39, pp. 70-71Koch, M., de Keyser, J., Tremlett, H., Timing of birth and disease progression in multiple sclerosis (2008) Mult Scler, 14, pp. 793-798Tremlett, H.L., Devonshire, V.A., Does the season or month of birth influence disease progression in multiple sclerosis? (2006) Neuroepidemiology, 26, pp. 195-198Poser, C.M., Paty, D.W., Scheinberg, L., New diagnostic criteria for multiple sclerosis: Guidelines for research protocols (1983) Ann Neurol, 13, pp. 227-231McDonald, W.I., Compston, A., Edan, G., Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the diagnosis of multiple sclerosis (2001) Ann Neurol, 50, pp. 121-127Polman, C.H., Reingold, S.C., Edan, G., Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria" (2005) Ann Neurol, 58, pp. 840-846Kurtzke, J.F., Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS) (1983) Neurology (Cleveland), 33, pp. 1444-1452Damasceno, A., von Glehn, F., de Deus-Silva, L., Monthly variation of multiple sclerosis activity in the Southern hemisphere: Analysis from 996 relapses in Brazil (2012) Eur J Neurol, 19, pp. 660-662Altmann, D.M., Review series on helminths, immune modulation and the hygiene hypothesis: Nematode coevolution with adaptive immunity, regulatory networks and the growth of inflammatory diseases (2009) Immunology, 126, pp. 1-2Correale, J., Farez, M.F., The impact of environmental infections (parasites) on MS activity (2011) Mult Scler, 17, pp. 1162-1169Watson, P.E., McDonald, B.W., Seasonal variation of nutrient intake in pregnancy: Effects on infant measures and possible influence on diseases related to season of birth (2007) Eur J Clin Nutr, 61, pp. 1271-1280Melcon, M., Melcon, C., Bartoloni, L., Towards establishing MS prevalence in Latin America and the Caribbean (2013) Mult Scler, 19, pp. 145-152. , The "Grupo Colaborativo Multicéntrico para el Estudio de la Esclerosis Multiple en America Latina y el Caribe" (GEEMAL)Taylor, B.V., Pearson, J.F., Clarke, G., MS prevalence in New Zealand, an ethnically and latitudinally diverse country (2010) Mult Scler, 16, pp. 1422-1431Dobson, R., Giovannoni, G., Ramagopalan, S., The month of birth effect in multiple sclerosis: Systematic review, meta-analysis and effect of latitude (2013) J Neurol Neurosurg Psychiatry, 84, pp. 427-43