283 research outputs found
Determination of the Blend Level of Mixtures of Biodiesel with Mineral Diesel Fuel Using Near Infrared Spectroscopy
Revisiting Host-Pathogen Interactions in Cystic Fibrosis Lungs in the Era of CFTR Modulators
Cystic fibrosis transmembrane conductance regulator (CFTR) modulators, a new series of therapeutics that correct and potentiate some classes of mutations of the CFTR, have provided a great therapeutic advantage to people with cystic fibrosis (pwCF). The main hindrances of the present CFTR modulators are related to their limitations in reducing chronic lung bacterial infection and inflammation, the main causes of pulmonary tissue damage and progressive respiratory insufficiency, particularly in adults with CF. Here, the most debated issues of the pulmonary bacterial infection and inflammatory processes in pwCF are revisited. Special attention is given to the mechanisms favoring the bacterial infection of pwCF, the progressive adaptation of Pseudomonas aeruginosa and its interplay with Staphylococcus aureus, the cross-talk among bacteria, the bronchial epithelial cells and the phagocytes of the host immune defenses. The most recent findings of the effect of CFTR modulators on bacterial infection and the inflammatory process are also presented to provide critical hints towards the identification of relevant therapeutic targets to overcome the respiratory pathology of pwCF
Extensive Sheep and Goat Production: The Role of Novel Technologies towards Sustainability and Animal Welfare
ReviewSheep and goat extensive production systems are very important in the context of global
food security and the use of rangelands that have no alternative agricultural use. In such systems,
there are enormous challenges to address. These include, for instance, classical production issues, such
as nutrition or reproduction, as well as carbon-efficient systems within the climate-change context.
An adequate response to these issues is determinant to economic and environmental sustainability.
The answers to such problems need to combine efficiently not only the classical production aspects,
but also the increasingly important health, welfare, and environmental aspects in an integrated fashion. The purpose of the study was to review the application of technological developments,
in addition to remote-sensing in tandem with other state-of-the-art techniques that could be used
within the framework of extensive production systems of sheep and goats and their impact on
nutrition, production, and ultimately, the welfare of these species. In addition to precision livestock
farming (PLF), these include other relevant technologies, namely omics and other areas of relevance
in small-ruminant extensive production: heat stress, colostrum intake, passive immunity, newborn
survival, biomarkers of metabolic disease diagnosis, and parasite resistance breeding. This work
shows the substantial, dynamic nature of the scientific community to contribute to solutions that
make extensive production systems of sheep and goats more sustainable, efficient, and aligned with
current concerns with the environment and welfareinfo:eu-repo/semantics/publishedVersio
Structural and functional leaf traits of two Gochnatia species from distinct growth forms in a sclerophyll forest site in Southeastern Brazil
Short, medium or long-term hormonal treatments for induction of synchronized estrus and ovulation in Saanen goats during the nonbreeding season
Interference of genotypes x environments interaction in the genetic control of resistance to Asian rust soybean
Susceptibility profile of Brazilian Rhodococcus equi isolates against azithromycin, clarithromycin and erythromycin
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