Concert recording 2014-11-30

[Track 01]. Wicca / Casey Cangelosi -- [Track 02]. Suomineito / Nebojsa Zivkovic -- [Track 03]. Velocities / Joseph Schwantner -- [Track 04]. Raga no. 1 / William Cahn -- [Track 05]. Pure imagination / arranged by Alex Stopa and Tyler Simmons -- [Track 06]. Catching shadows / Ivan Trevino

Solar Viability in the Historic District of Worthington

Course Code: ENR/AEDE 4567This project explores the economic viability of introducing solar energy within the Historic District of Worthington, Ohio as well as energy efficiency measures for the municipality.Academic Major: Environment, Economy, Development, and Sustainabilit

Guidance for Researchers: Feedback : Patient and Public Involvement (PPI): Feedback from Researchers to PPI Contributors

© 2018 The Author(s). This an open access work distributed under the terms of the Creative Commons Attribution Licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited

Smoking Prevalence Increases following Canterbury Earthquakes

Background. A magnitude 7.1 earthquake hit Canterbury in September 2010. This earthquake and associated aftershocks took the lives of 185 people and drastically changed residents’ living, working, and social conditions. Aim. To explore the impact of the earthquakes on smoking status and levels of tobacco consumption in the residents of Christchurch. Methods. Semistructured interviews were carried out in two city malls and the central bus exchange 15 months after the first earthquake. A total of 1001 people were interviewed. Results. In August 2010, prior to any earthquake, 409 (41%) participants had never smoked, 273 (27%) were currently smoking, and 316 (32%) were ex-smokers. Since the September 2010 earthquake, 76 (24%) of the 316 ex-smokers had smoked at least one cigarette and 29 (38.2%) had smoked more than 100 cigarettes. Of the 273 participants who were current smokers in August 2010, 93 (34.1%) had increased consumption following the earthquake, 94 (34.4%) had not changed, and 86 (31.5%) had decreased their consumption. 53 (57%) of the 93 people whose consumption increased reported that the earthquake and subsequent lifestyle changes as a reason to increase smoking. Conclusion. 24% of ex-smokers resumed smoking following the earthquake, resulting in increased smoking prevalence. Tobacco consumption levels increased in around one-third of current smokers

Correction to: Abstracts from the NIHR INVOLVE Conference 2017.

[This corrects the article DOI: 10.1186/s40900-017-0075-x.]

Genetic Signatures of Strong Recent Positive Selection at the Lactase Gene

In most human populations, the ability to digest lactose contained in milk usually disappears in childhood, but in European-derived populations, lactase activity frequently persists into adulthood (Scrimshaw and Murray 1988). It has been suggested (Cavalli-Sforza 1973; Hollox et al. 2001; Enattah et al. 2002; Poulter et al. 2003) that a selective advantage based on additional nutrition from dairy explains these genetically determined population differences (Simoons 1970; Kretchmer 1971; Scrimshaw and Murray 1988; Enattah et al. 2002), but formal population-genetics–based evidence of selection has not yet been provided. To assess the population-genetics evidence for selection, we typed 101 single-nucleotide polymorphisms covering 3.2 Mb around the lactase gene. In northern European–derived populations, two alleles that are tightly associated with lactase persistence (Enattah et al. 2002) uniquely mark a common (∼77%) haplotype that extends largely undisrupted for >1 Mb. We provide two new lines of genetic evidence that this long, common haplotype arose rapidly due to recent selection: (1) by use of the traditional FST measure and a novel test based on pexcess, we demonstrate large frequency differences among populations for the persistence-associated markers and for flanking markers throughout the haplotype, and (2) we show that the haplotype is unusually long, given its high frequency—a hallmark of recent selection. We estimate that strong selection occurred within the past 5,000–10,000 years, consistent with an advantage to lactase persistence in the setting of dairy farming; the signals of selection we observe are among the strongest yet seen for any gene in the genome

Depletion of Myo/Nog Cells in the Lens Mitigates Posterior Capsule Opacification in Rabbits.

Purpose: Posterior capsule opacification (PCO) is a vision-impairing disease that occurs in some adults and most children after cataract surgery. Contractile myofibroblasts contribute to PCO by producing wrinkles in the lens capsule that scatter light. Myofibroblasts in the lens originate from Myo/Nog cells named for their expression of the MyoD transcription factor and bone morphogenetic protein inhibitor noggin. In this study we tested the effects of depleting Myo/Nog cells on development of PCO. Methods: Myo/Nog cells were eliminated by injecting the G8 antibody conjugated to 3DNA nanocarriers for the cytotoxin doxorubicin (G8:3DNA:Dox) during cataract surgery in rabbits. The severity of PCO was scored by slit lamp analysis, gross and histologic observation, and immunofluorescence localization of α-smooth muscle actin. Results: G8:3DNA:Dox specifically induced cell death in Myo/Nog cells in the lens. None of the lenses administered G8:3DNA containing 9 to 36 μM doxorubicin developed greater than trace levels of central PCO and few myofibroblasts were present on the capsule. Less than 9% of these lenses exhibited greater than mild levels of peripheral PCO. Doxorubucin itself reduced PCO; however, myofibroblasts and wrinkles were abundant in the lens, and off-target effects were observed in the ciliary processes and cornea. Conclusions: Myo/Nog cells are the primary source of myofibroblasts in the lens after cataract surgery. Targeted depletion of Myo/Nog cells has potential for preventing PCO and preserving vision

Concert recording 2013-04-14b

[Track 01]. Winter spirits for solo flute / Katherine Hoover -- [Track 02]. Il bacio / Luigi Arditi -- [Track 03]. Sonata for flute and piano. First movement / Otar Taktakishvili -- [Track 04]. Euphonium Concerto. Andante ; [Track 05]. Finale-Giocoso / Vladimir Cosma -- [Track 06]. Flute concerto in D, op. 283. Allegro molto moderato / Carl Reinecke -- [Track 07]. White knuckle stroll / Casey Cangelosi -- [Track 08]. Into the air / Ivan Trevino -- [Track 09]. Horn concerto no. 1 in E♭ major. Allegro / Richard Strauss -- [Track 10]. Pulsar / Augusta Read Thomas -- [Track 11]. Concerto in F minor. Movement one / Oskar Bohme -- [Track 12]. Fugue in G minor, Little Fugue / J.S. Bach