Baseline characteristics and risk factors for ulcer, amputation and severe neuropathy in diabetic foot at risk: the brazupa study

CNPQ – CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOStudies on diabetic foot and its complications involving a significant and representative sample of patients in South American countries are scarce. The main objective of this study was to acquire clinical and epidemiological data on a large cohort of diabetic patients from 19 centers from Brazil and focus on factors that could be associated with the risk of ulcer and amputation. Methods: This study presents cross sectional, Baseline results of the BRAZUPA Study. A total of 1455 patients were included. Parameters recorded included age, gender, ethnicity, diabetes and comorbidity-related records, previous ulcer or amputation, clinical symptomatic score, foot classification and microvascular complications. Results: Patients with ulcer had longer disease duration (17.2 +/- 9.9 vs. 13.2 +/- 9.4 years; p < 0.001), and poorer glycemic control (HbA1c 9.23 +/- 2.03 vs. 8.35 +/- 1.99; p < 0.001). Independent risk factors for ulcer were male gender (OR 1.71; 95 % CI 1.2-3.7), smoking (OR 1.78; 95 % CI 1.09-2.89), neuroischemic foot (OR 20.34; 95 % CI 9.31-44.38), region of origin (higher risk for those from developed regions, OR 2.39; 95 % CI 1.47-3.87), presence of retinopathy (OR 1.68; 95 % CI 1.08-2.62) and absence of vibratory sensation (OR 7.95; 95 % CI 4.65-13.59). Risk factors for amputation were male gender (OR 2.12; 95 % CI 1.2-3.73), type 2 diabetes (OR 3.33; 95 % CI 1.01-11.1), foot at risk classification (higher risk for ischemic foot, OR 19.63; 95 % CI 3.43-112.5), hypertension (lower risk, OR 0.3; 95 % CI 0.14-0.63), region of origin (South/Southeast, OR 2.2; 95 % CI 1.1-4.42), previous history of ulcer (OR 9.66; 95 % CI 4.67-19.98) and altered vibratory sensation (OR 3.46; 95 % CI 1.64-7.33). There was no association between either outcome and ethnicity. Conclusions: Ulcer and amputation rates were high. Age at presentation was low and patients with ulcer presented a higher prevalence of neuropathy compared to ischemic foot at risk. Ischemic disease was more associated with amputations. Ethnical differences were not of great importance in a miscegenated population825CNPQ – CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOCNPQ – CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOsem informaçã

Identification of a major locus conferring resistance to powdery mildew (Erysiphe polygoni DC) in mungbean (Vigna radiata L. Wilczek) by QTL analysis

A major locus conferring resistance to the causal organism of powdery mildew, Erysiphe polygoni DC,, in mungbean (Vigna radiata L. Wilczek) was identified using QTL analysis with a population of 147 recombinant inbred individuals. The population was derived from a cross between 'Berken', a highly susceptible variety, and ATF 3640, a highly resistant line. To test for response to powdery mildew, F-7 and F-8 lines were inoculated by dispersing decaying mungbean leaves with residual conidia of E. polygoni amongst the young plants to create an artificial epidemic and assayed in a glasshouse facility. To generate a linkage map, 322 RFLP clones were tested against the two parents and 51 of these were selected to screen the mapping population. The 51 probes generated 52 mapped loci, which were used to construct a linkage map spanning 350 cM of the mungbean genome over 10 linkage groups. Using these markers, a single locus was identified that explained up to a maximum of 86% of the total variation in the resistance response to the pathogen

Escova dental e dedeira na remoção da placa bacteriana dental em cães The dental brush and thumb-stall in the removal of the dental plaque in dogs

A placa bacteriana é fator primário na formação de gengivite, cálculo dentário, halitose e doença periodontal. Objetivou-se avaliar a quantidade de placa bacteriana dental removida pela escova dental e dedeira. Foram utilizados 60 cães machos e fêmeas de diferentes raças, idade e peso, divididos em dois grupos. O índice Logan & Boyce foi utilizados para quantificar a placa bacteriana antes e após a escovação. Observou-se diferença estatística (p<0,05) na remoção da placa bacteriana antes e após escovação. Não houve diferença estatística (p>0,05) entre a utilização da escova dental e a dedeira.<br>The dental plaque is the primary factor for gingivitis formation, dental calculus, oral malodor and periodontal disease. To evaluate the amount of dental plaque removed by the dental brush and thumb-stall, 60 male and female dogs of different races, age and weight were divided in two groups and studies. The index of Logan & Boyce was used to quantify the dental plaque before and after the toothbrush. Statistical difference was observed (p <0.05) in the removal of the bacterial plate before and after toothbrush. There was not statistical difference (p>0.05) between the use of the dental brush and the thumb-stall

O clado Merianthera e as tribos Merianieae e Microliceae (Melastomataceae) na Serra Negra, Minas Gerais

Resumo Apresenta-se um estudo taxonômico do clado Merianthera e das tribos Merianieae e Microlicieae (Melastomataceae) na Serra Negra, localizada no Complexo da Mantiqueira, região sul da Zona da Mata de Minas Gerais, Brasil. O clado Merianthera está representado por Behuria parvifolia, Huberia nettoana e Cambessedesia hilariana, Merianieae está representada apenas por Meriania claussenii, enquanto Microlicieae está representada por Lavoisiera imbricata, Microlicia serpyllifolia, Rhynchanthera dichotoma, Trembleya elegans, Trembleya parviflora e Trembleya phlogiformis. A região vem sofrendo impactos devido à plantação de Pinus e Eucalyptus, especulação imobiliária, visitação desorganizada, coleta ilegal de plantas, bem como o aumento das áreas de pastagem, de modo que várias espécies se encontram sob constante ameaça. Em relação à conservação, deve-se ressaltar as espécies B. parvifolia, H. nettoana e M. claussenii, provavelmente ameaçadas de extinção a nível regional ou nacional. No presente artigo são apresentadas chaves de identificação, descrições, ilustrações, informações sobre distribuição geográfica e comentários morfológicos para os táxons desses grupos representados na Serra Negra