The Beam in Our Own Eyes: Antiracism and YA Literature Through a Catholic Lens

As Catholic schools serve an increasingly racially diverse population of students, they must grapple with the critical requirement to address these students’ unique needs while heeding the call from modern Catholic Church leaders to engage in explicit antiracist action. Using the Historically Responsive Literacy Framework (HRL), this article equips Catholic high school English language arts (ELA) teachers with practical and powerful ways to create antiracist curriculum. To do this effectively, we place antiracist Young Adult (YA) literature (both fiction and nonfiction) in conversation with Catholic canonical texts and modern voices from Catholic clergy members. By connecting with students’ complex identities and creating authentic antiracist learning experiences, Catholic high school ELA teachers can better prepare their students to use both their knowledge and criticality of Catholic social teachings and their individual identities to combat racism

Disease and Democracy: Understanding the Impact of Disease Burden on Civil Liberties and Civil Society in sub-Saharan Africa

What is the impact of disease burden on democracy in sub-Saharan Africa? Despite increasing interest in the implications of health crises for state stability, there has been a dearth of literature exploring the relationship between disease burden more generally and democracy specifically. This thesis takes a comprehensive approach to bridge this gap in the literature. Using quantitative and qualitative methods, it draws on data from the Global Burden of Disease database and the Varieties of Democracy (V-Dem) dataset to analyze this relationship. The diseases studied are categorized as long-wave (e.g., HIV/AIDS and tuberculosis), short-wave (e.g., Ebola and lower respiratory infections), or endemic (e.g., malaria and an aggregate of other infectious diseases). In terms of democracy, this thesis focuses on civil liberties and civil society. Having utilized a linear regression, controlling for economic variables, this study found a positive and significant relationship between long-wave diseases and both civil liberties and civil society; a negative and significant relationship between Ebola and both civil liberties and civil society; a positive and significant relationship between lower respiratory infections and both civil liberties and civil society; and, finally, a positive and significant relationship between the other infectious disease aggregate and civil society. Ultimately, there was no significant relationship between the other diseases studied and the democratic variables. By identifying past relationships between particular kinds of diseases and manifestations of democracy, we can establish a baseline from which to project our expectations about how emerging diseases like COVID-19 will impact the practice of democracy

Elevated amygdala responses to emotional faces in youths with chronic irritability or bipolar disorder

AbstractA major controversy in child psychiatry is whether bipolar disorder (BD) presents in children as severe, non-episodic irritability (operationalized here as severe mood dysregulation, SMD), rather than with manic episodes as in adults. Both classic, episodic BD and SMD are severe mood disorders characterized by deficits in processing emotional stimuli. Neuroimaging techniques can be used to test whether the pathophysiology mediating these deficits are similar across the two phenotypes. Amygdala dysfunction during face emotion processing is well-documented in BD, but little is known about amygdala dysfunction in chronically irritable youth. We compared neural activation in SMD (n=19), BD (n=19), and healthy volunteer (HV; n=15) youths during an implicit face-emotion processing task with angry, fearful and neutral expressions. In the right amygdala, both SMD and BD exhibited greater activity across all expressions than HV. However, SMD and BD differed from each other and HV in posterior cingulate cortex, posterior insula, and inferior parietal lobe. In these regions, only SMD showed deactivation in response to fearful expressions, whereas only BD showed deactivation in response to angry expressions. Thus, during implicit face emotion processing, youth with BD and those with SMD exhibit similar amygdala dysfunction but different abnormalities in regions involved in information monitoring and integration

The ISB Cancer Genomics Cloud: A Flexible Cloud-Based Platform for Cancer Genomics Research.

The ISB Cancer Genomics Cloud (ISB-CGC) is one of three pilot projects funded by the National Cancer Institute to explore new approaches to computing on large cancer datasets in a cloud environment. With a focus on Data as a Service, the ISB-CGC offers multiple avenues for accessing and analyzing The Cancer Genome Atlas, TARGET, and other important references such as GENCODE and COSMIC using the Google Cloud Platform. The open approach allows researchers to choose approaches best suited to the task at hand: from analyzing terabytes of data using complex workflows to developing new analysis methods in common languages such as Python, R, and SQL; to using an interactive web application to create synthetic patient cohorts and to explore the wealth of available genomic data. Links to resources and documentation can be found at www.isb-cgc.or

Two Generations of CubeSat Missions (CSSWE and CIRBE) to Take on the Challenges of Measuring Relativistic Electrons in the Earth’s Magnetosphere

The Colorado Student Space Weather Experiment (CSSWE) CubeSat, carrying the Relativistic Electron and Proton Telescope integrated little experiment (REPTile) to measure 0.5 to \u3e3.8 MeV electrons and 8-40 MeV protons, operated for over two years, 2012-2014, in low Earth orbit (LEO). There have been 25 peer-reviewed publications, including two in Nature, and five Ph.D. dissertations associated with CSSWE. Another 3U CubeSat mission: Colorado Inner Radiation Belt Electron Experiment (CIRBE), has been under development to address an unresolved science question: Where is the break point in terms of electron energy below which electrons can be transported into the inner belt from the outer belt but above which they cannot? This requires clean measurements of energetic electrons with fine energy resolution in an environment where all instruments are subject to the unforgiving penetration from highly energetic protons (tens of MeV to GeV). An advanced version of REPTile has been designed and built, REPTile-2. It has been integrated into the CIRBE bus, which has active attitude control, deployable solar panels, and a S-band radio, provided by Blue Canyon Technologies. CIRBE advances our science capabilities and has significantly improved performance vs. CSSWE and is ready to be launched into a LEO in early 2023

Consortium for the Study of Pregnancy Treatments (Co-OPT): An international birth cohort to study the effects of antenatal corticosteroids

BACKGROUND: Antenatal corticosteroids (ACS) are widely prescribed to improve outcomes following preterm birth. Significant knowledge gaps surround their safety, long-term effects, optimal timing and dosage. Almost half of women given ACS give birth outside the "therapeutic window" and have not delivered over 7 days later. Overtreatment with ACS is a concern, as evidence accumulates of risks of unnecessary ACS exposure. METHODS: The Consortium for the Study of Pregnancy Treatments (Co-OPT) was established to address research questions surrounding safety of medications in pregnancy. We created an international birth cohort containing information on ACS exposure and pregnancy and neonatal outcomes by combining data from four national/provincial birth registers and one hospital database, and follow-up through linked population-level data from death registers and electronic health records. RESULTS AND DISCUSSION: The Co-OPT ACS cohort contains 2.28 million pregnancies and babies, born in Finland, Iceland, Israel, Canada and Scotland, between 1990 and 2019. Births from 22 to 45 weeks' gestation were included; 92.9% were at term (≥ 37 completed weeks). 3.6% of babies were exposed to ACS (67.0% and 77.9% of singleton and multiple births before 34 weeks, respectively). Rates of ACS exposure increased across the study period. Of all ACS-exposed babies, 26.8% were born at term. Longitudinal childhood data were available for 1.64 million live births. Follow-up includes diagnoses of a range of physical and mental disorders from the Finnish Hospital Register, diagnoses of mental, behavioural, and neurodevelopmental disorders from the Icelandic Patient Registers, and preschool reviews from the Scottish Child Health Surveillance Programme. The Co-OPT ACS cohort is the largest international birth cohort to date with data on ACS exposure and maternal, perinatal and childhood outcomes. Its large scale will enable assessment of important rare outcomes such as perinatal mortality, and comprehensive evaluation of the short- and long-term safety and efficacy of ACS