Supply Chain Analysis of the Muscovado Sugar Industry in Antique, Philippines

In recent years, there is a growing preference for natural and healthy products resulting to increase in market demand for muscovado sugar in the domestic market and markets abroad. The Province of Antique, Philippines, used to be the key producer of muscovado sugar in the 1960s, producing 70% of the country’s total muscovado sugar. Production of muscovado sugar has declined, attributed to factors like domination of refined sugar in the over-all sugar industry, decline in volume and quality of sugar due to neglect, inefficient milling practices, and underdeveloped milling channels. This paper documents the muscovado sugar supply chain in the province of Antique to provide basis for policy makers and industry players towards industry revitalization and eventually increasing its level of competitiveness. Data was gathered using key informant interviews and expert opinion. In addition, surveys were conducted in 7 sugarcane-producing municipalities in Antique with 79 respondents, determined using a two-stage random sampling. The paper maps out the supply chain of muscovado sugar in Antique showing the actors, key processes, flow of product, payment and information, logistics issues and concerns, and external influences along the chain. Appropriate recommendations were made in accordance to the objective of increasing the industry’s level of performance and competitiveness. Specific participant-anchored and process-based strategies are recommended

Benchmarking Sugarcane Production and Management Technology for Muscovado Sugar in the Province of Antique, Western Visayas, Philippines

Long-term sustainability of industries such as an agri-food production system is essential in the light of pressures to satisfy diverse customer needs, comply with government regulations, and to maintain core competency as in response to stiffer market competition. This has led to the identification of best management practices for highly critical and important commodities as the case of muscovado sugar. This paper attempts to gauge the performance of sugarcane production and management technology for use in muscovado sugar production in the province of Antique vis-á-vis process-specific levels of sugarcane production technology as categorized by the Sugar Regulatory Administration. A survey was conducted in 7 sugarcane-producing municipalities in the Province of Antique with 79 respondents selected using two-stage random sampling. Results show that the industry is at par when it comes to best management practices along the areas of planting practices, planting material selection, closing in timing, harvesting practices, trash management, shuttle shaving, and variety programming. The industry in the province lags behind along the areas of soil preparation and fertilizer application. It is recommended that all interventions geared towards improving the industry performance be anchored on evidence-based research findings. Moreover, it is further recommended that to improve productivity in sugarcane production, the industry in Antique must capitalize on its strengths while working towards the improvement of critical areas mentioned

The roots of "Western European societal evolution". A concept of Europe by Jenő Szűcs

Jenő Szűcs wrote his essay entitled Sketch on the three regions of Europe in the early 1980s in Hungary. During these years, a historically well-argued opinion emphasising a substantial difference between Central European and Eastern European societies was warmly received in various circles of the political opposition. In a wider European perspective Szűcs used the old “liberty topos” which claims that the history of Europe is no other than the fulfillment of liberty. In his Sketch, Szűcs does not only concentrate on questions concerning the Middle Ages in Western Europe. Yet it is this stream of thought which brought a new perspective to explaining European history. His picture of the Middle Ages represents well that there is a way to integrate all typical Western motifs of post-war self-definition into a single theory. Mainly, the “liberty motif”, as a sign of “Europeanism” – in the interpretation of Bibó’s concept, Anglo-saxon Marxists and Weber’s social theory –, developed from medieval concepts of state and society and from an analysis of economic and social structures. Szűcs’s historical aspect was a typical intellectual product of the 1980s: this was the time when a few Central European historians started to outline non-Marxist aspects of social theory and categories of modernisation theories, but concealing them with Marxist terminology

IL28B SNP screening and distribution in the French Canadian population using a rapid PCR-based test

Single nucleotide polymorphisms (SNPs) in the proximity of the interleukin-28B (IL28B) gene can predict spontaneous resolution of hepatitis C virus (HCV) infection and response to interferon therapy. Screening for this polymorphism has become part of the standard criteria for the management of HCV-infected patients, hence the need for a rapid, cost-effective screening method. Here, we describe a rapid PCR-based test to screen for two IL28B SNPs (rs12979860 and rs8099917). We used this test to investigate IL28B polymorphism and prevalence in a cohort of French Canadian injection drug users who are part of a unique population known to have a strong genetic founder effect. This population had lower linkage disequilibrium between the two tested SNPs as compared to other cohorts (|d′| = 0.68, r = 0.59). The special genetic makeup should be considered in the management of HCV-infected patients within that population

Preliminary characterisation of gonad inhibiting hormone (GIH) gene and its expression pattern during vitellogenesis in giant tiger shrimp, Penaeus monodon Fabricius, 1798

Farming of giant tiger shrimp is one of the most important and relatively recent coastal food production sectors in India. Although great strides have been made in shrimp husbandry practices in growout systems, management of reproduction in captivity has not kept pace. Although several hormones are involved in crustacean reproduction, the inhibitory effect of gonad inhibiting hormone (GIH) is thought to be more intense than any other hormones. As an essential component of understanding the reproduction of Penaeus monodon, we characterised the expression pattern of GIH gene in the sinus gland in relation to the female gametogenic cycle. A 633 bp sequence was cloned from the eyestalk of P. monodon by RT PCR. The sequence comprises an open reading frame (ORF) of 291 bp that encodes a protein of 96 amino acids. The deduced protein was used to search the GenBank database using BlastP. Protein alignment with all known crustacean GIH revealed that homology of P. monodon GIH shares 61, 48, 46, 46 and 35% identity with Metapenaeus ensis, Nephrops norvegicus, Homarus americanus, Rimicaris kairei and Armadillidium vulgarae respectively. The RT PCR analysis shows that GIH mRNA is expressed mainly in the eyestalk of female. In order to find the expression profile of GIH during different reproductive cycle, P. monodon female was categorised into four major stages of maturation, using light microscopical observations as well as morphological characteristics. Eyestalk of all animals from different stages of maturation indicated that GIH is expressed in all stages of maturation, although the expression of GIH mRNA changes during different stages of vitellogenesis. In animals with immature ovary, the relative GIH mRNA level was found to be less, which peaked in previtellogenic phase and diminished in subsequent phases. Low GIH mRNA level during the immature (oogonial) phase is particularly intriguing and has application in the commercial aquaculture to select the brooder

CDC25B partners with PP2A to induce AMPK activation and tumor suppression in triple negative breast cancer

Cell division cycle 25 (CDC25) dual specificity phosphatases positively regulate the cell cycle by activating cyclin-dependent kinase/cyclin complexes. Here, we demonstrate that in addition to its role in cell cycle regulation, CDC25B functions as a regulator of protein phosphatase 2A (PP2A), a major cellular Ser/Thr phosphatase, through its direct interaction with PP2A catalytic subunit. Importantly, CDC25B alters the regulation of AMP-activated protein kinase signaling (AMPK) by PP2A, increasing AMPK activity by inhibiting PP2A to dephosphorylate AMPK. CDC25B depletion leads to metformin resistance by inhibiting metformin-induced AMPK activation. Furthermore, dual inhibition of CDC25B and PP2A further inhibits growth of 3D organoids isolated from patient derived xenograft model of breast cancer compared to CDC25B inhibition alone. Our study identifies CDC25B as a regulator of PP2A, and uncovers a mechanism of controlling the activity of a key energy metabolism marker, AMPK

Implementation of Automatic In-store Dryer for Improving Agriculture Product

The post-harvest agricultural products handling is important to improve quality and to reduce yield loss Shallot is one of perishable agricultural commodities. Inappropriate post-harvest handling of onion can causes loss in weight, damage bulbs because of rotten, moldy, and new shoots grow. The traditional process of drying agricultural commodities can takes around 7-9 days under direct sunlight and 3-4 weeks depending on weather conditions when restore in the drying room. This causes more time for post-harvest processing and farmers to be needed. The installation of the automatic instore dryer provides a solution where the drying time is less than a week with the level of humidity and temperature are based to the target set point and not too dependent on outdoor weather. While temperature conditions under regulated temperature, the heating process uses light bulb while the air circulation inside the instore is using the exhaust. The output signal of the controller will activate the incandescent and exhaust lights based on the difference between the sensing temperature and humidity sensors installed in the room and set point

Life-Threatening Docetaxel Toxicity in a Patient With Reduced-Function CYP3A Variants: A Case Report.

Docetaxel therapy occasionally causes severe and life-threatening toxicities. Some docetaxel toxicities are related to exposure, and inter-individual variability in exposure has been described based on genetic variation and drug-drug interactions that impact docetaxel clearance. Cytochrome P450 3A4 (CYP3A4) and CYP3A5 metabolize docetaxel into inactive metabolites, and this is the primary mode of docetaxel clearance. Supporting their role in these toxicities, increased docetaxel toxicities have been found in patients with reduced- or loss-of-function variants in CYP3A4 and CYP3A5. However, since these variants in CYP3A4 are rare, little is known about the safety of docetaxel in patients who are homozygous for the reduced-function CYP3A4 variants. Here we present a case of life-threatening (grade 4) pneumonitis, dyspnea, and neutropenia resulting from a single dose of docetaxel. This patient was (1) homozygous for CYP3A4*22, which causes reduced expression and is associated with increased docetaxel-related adverse events, (2) heterozygous for CYP3A4*3, a rare reduced-function missense variant, and (3) homozygous for CYP3A5*3, a common loss of function splicing defect that has been associated with increased docetaxel exposure and adverse events. The patient also carried functional variants in other genes involved in docetaxel pharmacokinetics that may have increased his risk of toxicity. We identified one additional CYP3A4*22 homozygote that received docetaxel in our research cohort, and present this case of severe hematological toxicity. Furthermore, the one other CYP3A4*22 homozygous patient we identified from the literature died from docetaxel toxicity. This case report provides further evidence for the need to better understand the impact of germline CYP3A variants in severe docetaxel toxicity and supports using caution when treating patients with docetaxel who have genetic variants resulting in CYP3A poor metabolizer phenotypes

Free-moving Quantitative Gamma-ray Imaging

The ability to map and estimate the activity of radiological source distributions in unknown three-dimensional environments has applications in the prevention and response to radiological accidents or threats as well as the enforcement and verification of international nuclear non-proliferation agreements. Such a capability requires well-characterized detector response functions, accurate time-dependent detector position and orientation data, an algorithmic understanding of the surrounding 3D environment, and appropriate image reconstruction and uncertainty quantification methods. We have previously demonstrated 3D mapping of gamma-ray emitters with free-moving detector systems on a relative intensity scale using a technique called Scene Data Fusion (SDF). Here we characterize the detector response of a multi-element gamma-ray imaging system using experimentally benchmarked Monte Carlo simulations and perform 3D mapping on an absolute intensity scale. We present experimental reconstruction results from hand-carried and airborne measurements with point-like and distributed sources in known configurations, demonstrating quantitative SDF in complex 3D environments.Comment: 19 pages, 5 figures, 4 supplementary figures, submitted to Scientific Reports - Natur