On the Origin of the Colour-Magnitude Relation in the Virgo Cluster

We explore the origin of the colour-magnitude relation (CMR) of early type galaxies in the Virgo cluster using spectra of very high S/N ratio for six elliptical galaxies selected along the CMR. The data are analysed using a new evolutionary stellar population synthesis model to generate galaxy spectra at the resolution given by their velocity dispersions. In particular we use a new age indicator that is virtually free of the effects of metallicity. We find that the luminosity weighted mean ages of Virgo ellipticals are greater than ~8 Gyr, and show no clear trend with galaxy luminosity. We also find a positive correlation of metallicity with luminosity, colour and velocity dispersion. We conclude that the CMR is driven primarily by a luminosity-metallicity correlation. However, not all elements increase equally with the total metallicity and we speculate that the CMR may be driven by both a total metallicity increase and by a systematic departure from solar abundance ratios of some elements along the CMR. A full understanding of the role played by the total metallicity, abundance ratios and age in generating the CMR requires the analysis of spectra of very high quality, such as those reported here, for a larger number of galaxies in Virgo and other clusters.Comment: To appear in The Astrophysical Journal Letters, 2001 April 20 (551, number 2). 5 pages and 4 figure

SAURON Observations of Disks in Early-Type Galaxies

We briefly describe the SAURON project, aimed at determining the intrinsic shape and internal dynamics of spheroids. We focus here on the ability of SAURON to identify gaseous and stellar disks and to measure their morphology and kinematics. We illustrate some of our results with complete maps of NGC3377, NGC3623, and NGC4365.Comment: 4 pages, 4 figures (newpasp.sty). To appear in ASP Conf. Series "Galaxy Disks and Disk Galaxies", eds. J.G. Funes S.J. & E.M. Corsini. Version with full resolution images available at http://www.strw.leidenuniv.nl/~bureau/pub_list.htm

Comparison of spheroids formed by rat glioma stem cells and neural stem cells reveals differences in glucose metabolism and promising therapeutic applications

Cancer stem cells (CSCs) are thought to be partially responsible for cancer resistance to current therapies and tumor recurrence. Dichloroacetate (DCA), a compound capable of shifting metabolism from glycolysis to glucose oxidation, via an inhibition of pyruvate dehydrogenase kinase was used. We show that DCA is able to shift the pyruvate metabolism in rat glioma CSCs but has no effect in rat neural stem cells. DCA forces CSCs into oxidative phosphorylation but does not trigger the production of reactive oxygen species and consecutive anti-cancer apoptosis. However, DCA, associated with etoposide or irradiation, induced a Bax-dependent apoptosis in CSCs in vitro and decreased their proliferation in vivo. The former phenomenon is related to DCA-induced Foxo3 and p53 expression, resulting in the overexpression of BH3-only proteins (Bad, Noxa, and Puma), which in turn facilitates Bax-dependent apoptosis. Our results demonstrate that a small drug available for clinical studies potentiates the induction of apoptosis in glioma CSCs

Kinematic and Structural Evolution of Field and Cluster Spiral Galaxies

To understand the processes that build up galaxies we investigate the stellar structure and gas kinematics of spiral and irregular galaxies out to redshift 1. We target 92 galaxies in four cluster (z = 0.3 & 0.5) fields to study the environmental influence. Their stellar masses derived from multiband VLT/FORS photometry are distributed around but mostly below the characteristic Schechter-fit mass. From HST/ACS images we determine morphologies and structural parameters like disk length, position angle and ellipticity. Combining the spectra of three slit positions per galaxy using the MXU mode of VLT/FORS2 we construct the two-dimensional velocity field from gas emission lines for 16 cluster members and 33 field galaxies. The kinematic position angle and flatness are derived by a Fourier expansion of elliptical velocity profiles. To trace possible interaction processes, we define three irregularity indicators based on an identical analysis of local galaxies from the SINGS project. Our distant sample displays a higher fraction of disturbed velocity fields with varying percentages (10%, 30% and 70%) because they trace different features. While we find far fewer candidates for major mergers than the SINS sample at z~2, our data are sensitive enough to trace less violent processes. Most irregular signatures are related to star formation events and less massive disks are affected more than Milky-Way type objects. We detect similarly high fractions of irregular objects both for the distant field and cluster galaxies with similar distributions. We conclude that we may witness the building-up of disk galaxies still at redshifts z~0.5 via minor mergers and gas accretion, while some cluster members may additionally experience stripping, evaporation or harassment interactions.Comment: 4 pages, 2 colour figures, to appear in the ASP Conference Series Proceedings of "Galaxies in Isolation: Exloring Nature vs. Nurture", Granada, 200

Approaching the Coverability Problem Continuously

The coverability problem for Petri nets plays a central role in the verification of concurrent shared-memory programs. However, its high EXPSPACE-complete complexity poses a challenge when encountered in real-world instances. In this paper, we develop a new approach to this problem which is primarily based on applying forward coverability in continuous Petri nets as a pruning criterion inside a backward coverability framework. A cornerstone of our approach is the efficient encoding of a recently developed polynomial-time algorithm for reachability in continuous Petri nets into SMT. We demonstrate the effectiveness of our approach on standard benchmarks from the literature, which shows that our approach decides significantly more instances than any existing tool and is in addition often much faster, in particular on large instances.Comment: 18 pages, 4 figure

The present-day galaxy population in spiral galaxies

Although there are many more stellar population studies of elliptical and lenticular galaxies, studies of spiral galaxies are catching up, due to higher signal to noise data on one hand, and better analysis methods on the other. Here I start by discussing some modern methods of analyzing integrated spectra of spiral galaxies, and comparing them with traditional methods. I then discuss some recent developments in our understanding of the stellar content of spiral galaxies, and their associated dust content. I discuss star formation histories, radial stellar population gradients, and stellar populations in sigma drops.Comment: 8 pages, Proceedings of 'Probing Stellar Populations out to the Distant Universe', Cefalu, Italy, Sep 7-19, 2008, AIP Conf. Proc. Series. Higher resolution version available at http://www.astro.rug.nl/~peletier/rfpcefalu.pd

Optical/NIR stellar absorption and emission-line indices from luminous infrared galaxies

We analyze a set of optical-to-near-infrared long-slit nuclear spectra of 16 infrared-luminous spiral galaxies. All of the studied sources present H$_2$ emission, which reflects the star-forming nature of our sample, and they clearly display H I emission lines in the optical. Their continua contain many strong stellar absorption lines, with the most common features due to Ca I, Ca II, Fe I, Na I, Mg I, in addition to prominent absorption bands of TiO, VO, ZrO, CN and CO. We report a homogeneous set of equivalent width (EW) measurements for 45 indices, from optical to NIR species for the 16 star-forming galaxies as well as for 19 early type galaxies where we collected the data from the literature. This selected set of emission and absorption-feature measurements can be used to test predictions of the forthcoming generations of stellar population models. We find correlations among the different absorption features and propose here correlations between optical and NIR indices, as well as among different NIR indices, and compare them with model predictions. While for the optical absorption features the models consistently agree with the observations,the NIR indices are much harder to interpret. For early-type spirals the measurements agree roughly with the models, while for star-forming objects they fail to predict the strengths of these indices.Comment: accepted for publication in MNRA