A methodology to estimate baseline energy use and quantify savings in electrical energy consumption in higher education institution buildings: Case study, Federal University of Itajubá (UNIFEI)

Accurately forecasting energy consumption in a building is an important strategy for achieving the goal of reducing energy demand and improving energy efficiency. University campuses represent specific groups of diverse buildings with significant energy consumption. Therefore, they provide an excellent testbed to characterize and understand the energy consumption of a group of mixed-use buildings. This paper presents a novel methodology that considers the recommendations of ISO 50001: 2011 and ISO 50006: 2014 for establishing energy baselines and energy performance indicators in higher education institution buildings to identify electrical energy consumption reduction potentials in buildings and establish energy management strategies related to electricity use. The study was implemented in three buildings at the Federal University of Itajubá (José Rodrigues Seabra Campus). Several methods and indicators were evaluated to monitor and measure energy performance in buildings. A wide range of factors that influence operating system energy consumption in the buildings were studied and taken into account, such as the types of activities carried out in the building, weather conditions, building materials, air conditioning system and occupancy, since these contribute directly and indirectly to the difficulty of accurately measuring the building’s energy consumption. The results showed that potential annual savings in electric energy consumption for the campus could be around 9.6%, which translates into a R$ 93,647.2 economic value and a 20.3 tCO2eq emissions reduction without economic investment. It was concluded that the methodology proposed for establishing and monitoring an energy efficiency indicator can be applied to any institute of higher education because it is flexible and adaptable since each institute can define the period of analysis for the indicator. This research is expected to provide theoretical guidance and a practical data reference for relevant evaluations of building energy efficiency

Síndrome de quilomicronemia familiar, deficiencia del factor de maduración de lipasa

. Introducción: el síndrome de quilomicronemia familiar se considera un trastorno autosómico recesivo, poco frecuente, que puede presentarse clínicamente desde la infancia, pero se manifiesta después de su debut a cualquier edad. Clínicamente se presenta con dolor abdominal, pancreatitis aguda recurrente, xantomas cutáneos y hepatoesplomegalia. Por NGS su confirmación precisa que la variante encontrada siempre es bialélica; los progenitores por definición son heterocigotos para la misma variante y no presentan la enfermedad, solo portan la mutación sin presentar síntomas. Objetivo: investigar la presencia de la quilomicronemia y determinar su patrón de herencia, ya sea como una forma familiar con un patrón monogénico bialélico o como una condición de naturaleza multifactorial. Presentación del caso: se presenta el caso de un paciente con múltiples comorbilidades que acude por dolor abdominal e hipertrigliceridemia de etiología no filiada, al cual se le envían estudios genéticos para filiar la etiología y establecer un tratamiento adecuado. Discusión y conclusión: se realiza un estudio genético de análisis molecular por secuenciación de nueva generación, identificado en homocigosis en el gen LMF1. Esta variante se caracteriza por ser patogénica. Para diagnosticar el síndrome de quilomicronemia se deben identificar variantes bialélicas no patogénicas en el complejo LPL y proteínas relacionadas. El tratamiento consiste en la restricción de grasa en la dieta para reducir la morbilidad y mortalidad, así como el seguimiento por parte de genética para el estudio de familiares con riesgo

Activity patterns of tayra (Eira barbara) across their distribution

Species' activity patterns are driven by the need to meet basic requirements of food, social interactions, movement, and rest, but often are influenced by a variety of biotic and abiotic factors. We used camera-trap data to describe and compare the activity patterns of the relatively poorly studied tayra (Eira barbara) across 10 populations distributed from the south of Mexico to the north of Argentina, and attempted to identify biotic or abiotic factors that may be associated with variation in level of diurnality. In a subset of sites we also aimed to document potential seasonal variation in activity. We used a kernel density estimator based on the time of independent photographic events to calculate the proportion of diurnal, crepuscular, and nocturnal activity of each population. Tayras were mostly active during diurnal periods (79.31%, 759 records), with a lower proportion of crepuscular activity (18.07%, 173 records) yet we documented some variation in patterns across the 10 study areas (activity overlap coefficient varied from Δ4 = 0.64 to Δ1 = 0.95). In northern localities, activity peaked twice during the day (bimodal) with most activity ocurring in the morning, whereas closer to the geographical equator, activity was constant (unimodal) throughout the day, peaking at midday: activity either was unimodal or bimodal in southern localities. Despite investigating multiple potential abiotic and biotic predictors, only latitude was associated with variation in the proportion of diurnal activity by tayras across its range, with increased diurnal activity closer to the equator. Seasonal comparisons in activity showed a tendency to reduce diurnality in dry versus rainy seasons, but the pattern was not consistently significant. This is the most comprehensive description of tayra activity patterns to date, and lends novel insight into the potential flexibility of the species to adapt to local conditions.Fil: Villafañe Trujillo, Álvaro José. Universidad Autonoma de Queretaro.; MéxicoFil: Kolowski, Joseph M.. Instituto de Pesquisas Ecológicas; BrasilFil: Cove, Michael V.. University of Belize; BeliceFil: Medici, Emilia Patricia. Instituto de Pesquisas Ecológicas; BrasilFil: Harmsen, Bart J.. University of Belize; BeliceFil: Foster, Rebbeca J.. University of Belize; BeliceFil: Hidalgo Mihart, Mircea G.. Universidad Juárez Autónoma de Tabasco,; MéxicoFil: Espinosa, Santiago. Universidad Autónoma de San Luis Potosí; MéxicoFil: Ríos Alvear, Gorky. Universidad de Porto; PortugalFil: Reyes Puig, Carolina. Universidad de Porto; PortugalFil: Reyes Puig, Juan Pablo. Universidad de Porto; PortugalFil: Da Silva, Marina Xavier. Universidad Central del Ecuador; EcuadorFil: Paviolo, Agustin Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Universidad Nacional de Misiones. Instituto de Biología Subtropical; ArgentinaFil: Cruz, Paula Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Universidad Nacional de Misiones. Instituto de Biología Subtropical; ArgentinaFil: López González, Carlos Alberto. Universidad Autonoma de Queretaro.; Méxic

Overactive bladder-18 years - Part II

Traditionally, the treatment of overactive bladder syndrome has been based on the use of oral medications with the purpose of reestablishing the detrusor stability. The recent better understanding of the urothelial physiology fostered conceptual changes, and the oral anticholinergics - pillars of the overactive bladder pharmacotherapy - started to be not only recognized for their properties of inhibiting the detrusor contractile activity, but also their action on the bladder afference, and therefore, on the reduction of the symptoms that constitute the syndrome. Beta-adrenergic agonists, which were recently added to the list of drugs for the treatment of overactive bladder, still wait for a definitive positioning - as either a second-line therapy or an adjuvant to oral anticholinergics. Conservative treatment failure, whether due to unsatisfactory results or the presence of adverse side effects, define it as refractory overactive bladder. In this context, the intravesical injection of botulinum toxin type A emerged as an effective option for the existing gap between the primary measures and more complex procedures such as bladder augmentation. Sacral neuromodulation, described three decades ago, had its indication reinforced in this overactive bladder era. Likewise, the electric stimulation of the tibial nerve is now a minimally invasive alternative to treat those with refractory overactive bladder. The results of the systematic literature review on the oral pharmacological treatment and the treatment of refractory overactive bladder gave rise to this second part of the review article Overactive Bladder - 18 years, prepared during the 1st Latin-American Consultation on Overactive Bladder.Univ Fed Sao Paulo, EPM, Sao Paulo, SP, BrazilUniv Sao Paulo, Dept Urol, BR-05508 Sao Paulo, SP, BrazilFac Med ABC, Dept Urol, Sao Paulo, SP, BrazilUniv Los Andes, Dept Urol, Bogota, ColombiaEscuela Med Mil, Dept Urol, Mexico City, DF, MexicoHosp Clin Jose San Martin, Catedra Urol, Buenos Aires, DF, ArgentinaMae de Deus Ctr Hosp, Dept Urol, Porto Alegre, RS, BrazilUniv Fed Ciencias Saude Porto Alegre, Porto Alegre, RS, BrazilAC Camargo Hosp, Dept Urol, Sao Paulo, SP, BrazilHosp Clinico Fuerza Area Chile, Santiago, ChileInst Mexicano Seguro Social, Mexico City, DF, MexicoHosp Souza Aguiar, Dept Urol, Rio De Janeiro, RJ, BrazilComplejo Med Policial Churruca Visca, Serv Urol, Buenos Aires, DF, ArgentinaCtr Policlin Valencia Vina, Valencia, VenezuelaHosp Pablo Tobon Uribe, Medellin, ColombiaClin Indisa, Serv Urol, Providencia, ChileCtr Reabilitacao & Readaptacao Dr Henriqe Santill, Goiania, Go, BrazilHosp Univ Caracas, Serv Urol, Caracas, VenezuelaUniv Fed Ceara, Div Urol, Fortaleza, Ceara, BrazilUniv Fed Sao Paulo, EPM, Sao Paulo, SP, BrazilWeb of Scienc

Overactive bladder-18 years - Part I

Overactive bladder syndrome is one of the lower urinary tract dysfunctions with the highest number of scientific publications over the past two decades. This shows the growing interest in better understanding this syndrome, which gathers symptoms of urinary urgency and increased daytime and nighttime voiding frequency, with or without urinary incontinence and results in a negative impact on the quality of life of approximately one out of six individuals - including both genders and almost all age groups. The possibility of establishing the diagnosis just from clinical data made patients' access to specialized care easier. Physiotherapy resources have been incorporated into the urological daily practice. A number of more selective antimuscarinic drugs with consequent lower adverse event rates were released. Recently, a new class of oral drugs, beta-adrenergic agonists has become part of the armamentarium for Overactive Bladder. Botulinum toxin injections in the bladder and sacral neuromodulation are routine modalities of treatment for refractory cases. During the 1st Latin-American Consultation on Overactive Bladder, a comprehensive review of the literature related to the evolution of the concept, epidemiology, diagnosis, and management was conducted. This text corresponds to the first part of the review Overactive Bladder 18-years.Univ Fed Sao Paulo, EPM, Rua Dr Oscar Monteiro Barros 617-141, BR-05641010 Sao Paulo, SP, BrazilUniv Sao Paulo, Dept Urol, BR-05508 Sao Paulo, SP, BrazilFac Med ABC, Dept Urol, Sao Paulo, SP, BrazilUniv Los Andes, Dept Urol, Bogota, ColombiaEscuela Med, Dept Urol, Mexico City, DF, MexicoHosp Clin Jose San Martin, Catedra Urol, Buenos Aires, DF, ArgentinaMae de Deus Ctr Hosp, Dept Urol, Porto Alegre, RS, BrazilUniv Fed Ciencias Saude Porto Alegre, Porto Alegre, RS, BrazilAC Camargo Hosp, Dept Urol, Sao Paulo, BrazilHosp Clin Fuerza Area Chile, Santiago, ChileInst Mexicano Seguro Social, Mexico City, DF, MexicoHosp Souza Aguiar, Dept Urol, Rio De Janeiro, RJ, BrazilComplejo Med Policial Churruca Visca, Serv Urol, Buenos Aires, DF, ArgentinaCtr Policlin Valencia Vina, Valencia, VenezuelaHosp Pablo Tobon Uribe, Medellin, ColombiaClin Indisa, Serv Urol, Providencia, ChileCtr Reabilitacao & Readaptacao Dr Henriqe Santill, Goiania, Go, BrazilHosp Univ Caracas, Serv Urol, Caracas, VenezuelaUniv Fed Ceara, Div Urol, Fortaleza, Ceara, BrazilUniv Fed Sao Paulo, EPM, Rua Dr Oscar Monteiro Barros 617-141, BR-05641010 Sao Paulo, SP, BrazilWeb of Scienc

Colombian consensus recommendations for diagnosis, management and treatment of the infection by SARS-COV-2/ COVID-19 in health care facilities - Recommendations from expert´s group based and informed on evidence

La Asociación Colombiana de Infectología (ACIN) y el Instituto de Evaluación de Nuevas Tecnologías de la Salud (IETS) conformó un grupo de trabajo para desarrollar recomendaciones informadas y basadas en evidencia, por consenso de expertos para la atención, diagnóstico y manejo de casos de Covid 19. Estas guías son dirigidas al personal de salud y buscar dar recomendaciones en los ámbitos de la atención en salud de los casos de Covid-19, en el contexto nacional de Colombia