Elliptic solutions of generalized Brans-Dicke gravity with a non-universal coupling

We study a model of the generalized Brans-Dicke gravity presented in both the Jordan and in the Einstein frames, which are conformally related. We show that the scalar field equations in the Einstein frame are reduced to the geodesics equations on the target space of the nonlinear sigma-model. The analytical solutions in elliptical functions are obtained when the conformal couplings are given by reciprocal exponential functions. The behavior of the scale factor in the Jordan frame is studied using numerical computations. For certain parameters the solutions can describe an accelerated expansion. We also derive an analytical approximation in exponential functions.Comment: 24 pages, 3 figures; v2: typos fixed, few remarks and references added; version to appear in EPJ

On the origin of subvisible cirrus clouds in the tropical upper troposphere

Spaceborne lidar observations have recently revealed a previously undetected significant population of Subvisible Cirrus (SVC). We show them to be colder than −74 °, with an optical depth below 0.0015 on average. The formation and persistence over time of this new cloud population could be related to several atmospheric phenomena. In this paper, we investigate if these clouds follow the same formation mechanisms as the general tropical cirrus population (including convection and in-situ ice nucleation), or if specific nucleation sites and trace species play a role in their formation. The importance of three scenarios in the formation of the global SVC population is investigated through different approaches that include comparisons with data imaging from several spaceborne instruments and back-trajectories that document the history and behavior of air masses leading to the point in time and space where subvisible cirrus were detected. In order to simplify the study of their formation, we singled out SVC with coherent temperature histories (mean variance lower than 4 K) according to back-trajectories along 5, 10 or 15 days (respectively 58, 25 and 11% of SVC). Our results suggest that external processes, including local increases in liquid and hygroscopic aerosol concentration (either through biomass burning or volcanic injection forming sulfate-based aerosols in the troposphere or the stratosphere) have very limited short-term or mid-term impact on the SVC population. On the other hand, we find that ~20% of air masses leading to SVC formation interacted with convective activity 5 days before they led to cloud formation and detection, a number that climbs to 60% over 15 days. SVC formation appears especially linked to convection over Africa and Central America, more so during JJA than DJF. These results support the view that the SVC population observed by CALIOP is an extension of the general upper tropospheric ice clouds population with its extreme thinness as its only differentiating factor

Effects of solar activity on noise in CALIOP profiles above the South Atlantic Anomaly

We show that nighttime dark noise measurements from the spaceborne lidar CALIOP contain valuable information about the evolution of upwelling high-energy radiation levels. Above the South Atlantic Anomaly (SAA), CALIOP dark noise levels fluctuate by ±6% between 2006 and 2013, and follow the known anticorrelation of local particle flux with the 11-year cycle of solar activity (with a 1-year lag). By analyzing the geographic distribution of noisy profiles, we are able to reproduce known findings about the SAA region. Over the considered period, it shifts westward by 0.3° year⁻¹, and changes in size by 6° meridionally and 2° zonally, becoming larger with weaker solar activity. All results are in strong agreement with previous works. We predict SAA noise levels will increase anew after 2014, and will affect future spaceborne lidar missions most near 2020

[3H]Adenine is a suitable radioligand for the labeling of G protein-coupled adenine receptors but shows high affinity to bacterial contaminations in buffer solutions

[3H]Adenine has previously been used to label the newly discovered G protein-coupled murine adenine receptors. Recent reports have questioned the suitability of [3H]adenine for adenine receptor binding studies because of curious results, e.g. high specific binding even in the absence of mammalian protein. In this study, we showed that specific [3H]adenine binding to various mammalian membrane preparations increased linearly with protein concentration. Furthermore, we found that Tris-buffer solutions typically used for radioligand binding studies (50 mM, pH 7.4) that have not been freshly prepared but stored at 4°C for some time may contain bacterial contaminations that exhibit high affinity binding for [3H]adenine. Specific binding is abolished by heating the contaminated buffer or filtering it through 0.2-μm filters. Three different, aerobic, gram-negative bacteria were isolated from a contaminated buffer solution and identified as Achromobacter xylosoxidans, A. denitrificans, and Acinetobacter lwoffii. A. xylosoxidans, a common bacterium that can cause nosocomial infections, showed a particularly high affinity for [3H]adenine in the low nanomolar range. Structure–activity relationships revealed that hypoxanthine also bound with high affinity to A. xylosoxidans, whereas other nucleobases (uracil, xanthine) and nucleosides (adenosine, uridine) did not. The nature of the labeled site in bacteria is not known, but preliminary results indicate that it may be a high-affinity purine transporter. We conclude that [3H]adenine is a well-suitable radioligand for adenine receptor binding studies but that bacterial contamination of the employed buffer solutions must be avoided

Molecular basis of USP7 inhibition by selective small-molecule inhibitors

Ubiquitination controls the stability of most cellular proteins, and its deregulation contributes to human diseases including cancer. Deubiquitinases remove ubiquitin from proteins, and their inhibition can induce the degradation of selected proteins, potentially including otherwise 'undruggable' targets. For example, the inhibition of ubiquitin-specific protease 7 (USP7) results in the degradation of the oncogenic E3 ligase MDM2, and leads to re-activation of the tumour suppressor p53 in various cancers. Here we report that two compounds, FT671 and FT827, inhibit USP7 with high affinity and specificity in vitro and within human cells. Co-crystal structures reveal that both compounds target a dynamic pocket near the catalytic centre of the auto-inhibited apo form of USP7, which differs from other USP deubiquitinases. Consistent with USP7 target engagement in cells, FT671 destabilizes USP7 substrates including MDM2, increases levels of p53, and results in the transcription of p53 target genes, induction of the tumour suppressor p21, and inhibition of tumour growth in mice

Elliptic solutions of generalized Brans–Dicke gravity with a non-universal coupling

We study a model of the generalized Brans–Dicke gravity presented in both the Jordan and in the Einstein frames, which are conformally related. We show that the scalar field equations in the Einstein frame are reduced to the geodesics equations on the target space of the nonlinear sigma model. The analytical solutions in elliptical functions are obtained when the conformal couplings are given by reciprocal exponential functions. The behavior of the scale factor in the Jordan frame is studied using numerical computations. For certain parameters the solutions can describe an accelerated expansion. We also derive an analytical approximation in exponential functions. © 2014, The Author(s)

Elliptic solutions of generalized Brans–Dicke gravity with a non-universal coupling

We study a model of the generalized Brans–Dicke gravity presented in both the Jordan and in the Einstein frames, which are conformally related. We show that the scalar field equations in the Einstein frame are reduced to the geodesics equations on the target space of the nonlinear sigma model. The analytical solutions in elliptical functions are obtained when the conformal couplings are given by reciprocal exponential functions. The behavior of the scale factor in the Jordan frame is studied using numerical computations. For certain parameters the solutions can describe an accelerated expansion. We also derive an analytical approximation in exponential functions. © 2014, The Author(s)

Digestion anaérobie des boues résiduaires : état des lieux de la situation française

International audienceFollowing the French environmental national debate, called ‘Grenelle de l’Environnement’ and according to the Kyoto Protocol, France looks at increasing its production of renewable energies, among them biogas production from organic wastes and more specifically from sewage sludge. A quick survey of official data shows that in 2009, sludge biogas only represented 0.93% of the total renewable electricity production, far from the situation in the neighbourhood countries. To understand this situation, this article aims at inventorying sludge anaerobic digestion process, in Europe then more precisely in France. The different technologies used to perform anaerobic digestion process have been investigated, including the type of waste, pre-treatments, digester specificities, mixing and heating systems. In France, a survey has been realised to determine the situation for wastewater treatments plants bigger than 30,000 equivalent inhabitants. Mesophilic digestion in a constantly mixed reactor is mainly used. Moreover, some plants have given specific details about the cost of the process or its efficiency. These results are discussed