Область применения битумоминерального сырья

Field of bitumen-mineral raw material (asphalt concrete scrap) application depends on deformational and strength characteristics that are changing in the process of asphalt concrete pavement service life due to transport load and weather and climatic factors. It is important to make a correct design of bitumen-mineral mixture with due account of test data of bitumen-mineral raw material and the required amount of organic binding and regenerating agents that are added with the purpose to rejuvenate the old bitumen.Область применения битумоминерального сырья (асфальтобетонного лома) зависит от деформационно-прочностных характеристик, которые изменялись в течение службы асфальтобетона в покрытии под воздействием транспортных нагрузок и погодно-климатических факторов. Важно правильно запроектировать битумоминеральную смесь с учетом данных испытаний битумоминерального сырья и необходимого количества добавляемого органического вяжущего и регенерирующих добавок, которые «омолаживают» состарившийся битум

Biosensors for early diagnostics of Hepatitis C: preparation and properties exploration

The research side was supported by the Russian Science Foundation (project № 19-73-00131) and by the European Regional Development Fund and the programme Mobilitas Pluss (project № MOBJD489)

Interaction of Nd:YAG Laser Radiation with Bovine Serum Albumin Solution

In this paper, the effect of Nd:YAG laser radiation on the properties of the BSA protein is investigated. A solution with a protein concentration of 5 mg/ml was irradiated for 30 minutes. After a 5-minute and 30-minute exposure, absorption spectra were taken, the particle size in the solution was determined by dynamic light scattering (DLS), the refractive index was determined, and fluorescent maps were taken. Raman spectroscopy of proteins was also performed. The results showed that after irradiation, the absorption of the protein solution decreases in the spectral range corresponding to amino acid residues. In DLS experiments, it was shown that the peak corresponding to protein molecules decreases, and the peaks corresponding to large aggregates (>100 nm) grow. Raman spectroscopy has shown that there is a decrease in intensity at a wavelength of 1570 cm-1. There were no significant changes in the refractive indices and the shape of the fluorescent maps. The data suggest that partial denaturation of proteins took place

New records of exotic spiders and insects to the Azores, and new data on recently introduced species

The introduction of exotic species in islands is recognized as a major threat to native biota and ecosystems. In this contribution we list thirteen widespread exotic invertebrate species (two Araneae, one Orthoptera, four Hemiptera, four Coleoptera and two Diptera) that were recorded from the Azorean Islands in the last few years for the first time. In addition, we list another ten invertebrate species (two Araneae, one Orthoptera, two Phasmatodea, one Hemiptera, three Coleoptera and one Diptera) that expanded their known range in the archipelago. The pathways of entrance for species in the Azores, their impact on the local economy and biodiversity, as well as strategies to halt the introduction of alien species are discussed

Evaluation of an internet-based behavioral intervention to improve psychosocial health outcomes in children with insomnia (Better Nights, Better Days): Protocol for a randomized controlled trial

Background: Up to 25% of 1- to 10-year-old children experience insomnia (ie, resisting bedtime, trouble falling asleep, night awakenings, and waking too early in the morning). Insomnia can be associated with excessive daytime sleepiness and negative effects on daytime functioning across multiple domains (eg, behavior, mood, attention, and learning). Despite robust evidence supporting the effectiveness of behavioral treatments for insomnia in children, very few children with insomnia receive these treatments, primarily due to a shortage of available treatment resources. Objective: The Better Nights, Better Days (BNBD) internet-based program provides a readily accessible electronic health (eHealth) intervention to support parents in providing evidence-based care for insomnia in typically developing children. The purpose of the randomized controlled trial (RCT) is to evaluate the effectiveness of BNBD in treating insomnia in children aged between 1 and 10 years. Methods: BNBD is a fully automated program, developed based on evidence-based interventions previously tested by the investigators, as well as on the extant literature on this topic. We describe the 2-arm RCT in which participants (500 primary caregivers of children with insomnia residing in Canada) are assigned to intervention or usual care. Results: The effects of this behavioral sleep eHealth intervention will be assessed at 4 and 8 months postrandomization. Assessment includes both sleep (actigraphy, sleep diary) and daytime functioning of the children and daytime functioning of their parents. Results will be reported using the standards set out in the Consolidated Standards of Reporting Trials statement. Conclusions: If the intervention is supported by the results of the RCT, we plan to commercialize this program so that it is sustainable and available at a low cost to all families with internet access

Оценка остаточной пластичности и трещиностойкости локально деформированных зон сварных конструкций

The technical condition of the load-lifting cranes, belonging to the dangerous industrial objects, is defined by a technical condition of bearing metalworks and demands constant quality assurance of connections and units. Special danger is represented by welded seams near to which there are the local plastically deformed zones leading to the brittle behavior of metal and to crack formation. A method of an estimation of crack resistance, based on measurement in the specified zones of hardness on Brinell and definition on its value of level of plastic damage of metal, and also of the remained stock of plasticity, is offered. The method differs in simplicity of execution, profitability and high reliability of results of research. It allows to carry out the current control of a condition for the purpose of definition of degree of danger and an establishment of a deadline of service of a design.Техническое состояние грузоподъемных кранов, относящихся к опасным производственным объектам, определяется техническим состоянием несущих металлоконструкций и требует постоянного контроля качества соединений и узлов. Особую опасность представляют сварные швы, вблизи которых возникают локально пластически деформированные зоны, приводящие к охрупчиванию металла и трещинообразованию. Предложен метод оценки трещиностойкости, основанный на измерении в указанных зонах твердости по Бринеллю и определении по ее значению уровня пластического повреждения металла, а также оставшегося запаса пластичности. Метод отличается простотой исполнения, экономичностью и высокой достоверностью результатов исследования. Он позволяет проводить текущий контроль состояния с целью определения степени опасности и установления предельного срока службы конструкции

ВЛИЯНИЕ КОНСТРУКТИВНО-ТЕХНОЛОГИЧЕСКИХ ДЕФЕКТОВ НА ПРОЧНОСТЬ АРМАТУРНЫХ СТЕРЖНЕЙ

The paper contains calculation on durability of a reinforcement bars with a constructive and technological defect. The factors determining constructive and technological durability of reinforcing bars have been investigated in the paper. The paper demonstrates classification of reinforcement bar parts in accordance with danger of constructive and technological influences.  Выполнен расчет на прочность арматурного стержня с конструктивно-технологическим дефектом. Рассмотрены факторы, определяющие конструктивно-технологическую прочность арматурного проката. Приведена классификация участков арматурного стержня по опасности конструктивно-технологических воздействий

Genetic variants for head size share genes and pathways with cancer

The size of the human head is highly heritable, but genetic drivers of its variation within the general population remain unmapped. We perform a genome-wide association study on head size (N = 80,890) and identify 67 genetic loci, of which 50 are novel. Neuroimaging studies show that 17 variants affect specific brain areas, but most have widespread effects. Gene set enrichment is observed for various cancers and the p53, Wnt, and ErbB signaling pathways. Genes harboring lead variants are enriched for macrocephaly syndrome genes (37-fold) and high-fidelity cancer genes (9-fold), which is not seen for human height variants. Head size variants are also near genes preferentially expressed in intermediate progenitor cells, neural cells linked to evolutionary brain expansion. Our results indicate that genes regulating early brain and cranial growth incline to neoplasia later in life, irrespective of height. This warrants investigation of clinical implications of the link between head size and cancer.</p

Differential Genetic Susceptibility to Child Risk at Birth in Predicting Observed Maternal Behavior

This study examined parenting as a function of child medical risks at birth and parental genotype (dopamine D4 receptor; DRD4). Our hypothesis was that the relation between child risks and later maternal sensitivity would depend on the presence/absence of a genetic variant in the mothers, thus revealing a gene by environment interaction (GXE). Risk at birth was defined by combining risk indices of children's gestational age at birth, birth weight, and admission to the neonatal intensive care unit. The DRD4-III 7-repeat allele was chosen as a relevant genotype as it was recently shown to moderate the effect of environmental stress on parental sensitivity. Mothers of 104 twin pairs provided DNA samples and were observed with their children in a laboratory play session when the children were 3.5 years old. Results indicate that higher levels of risk at birth were associated with less sensitive parenting only among mothers carrying the 7-repeat allele, but not among mothers carrying shorter alleles. Moreover, mothers who are carriers of the 7-repeat allele and whose children scored low on the risk index were observed to have the highest levels of sensitivity. These findings provide evidence for the interactive effects of genes and environment (in this study, children born at higher risk) on parenting, and are consistent with a genetic differential susceptibility model of parenting by demonstrating that some parents are inherently more susceptible to environmental influences, both good and bad, than are others