927 research outputs found

    Strengthening International Disaster Risk Reduction through Collaboration with China

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    Natural disasters hit developing countries particularly hard. Worldwide, the incidence and intensity of such disasters remain substantial. There were 6,873 natural disasters worldwide between 1994 and 2013, with 1.35 million lives lost (around 68,000 lives on average annually). Some 218 million people were affected by natural disasters on average per annum during this period. China’s history of catastrophic and major natural disasters has led it to reform its disaster risk reduction (DRR) and disaster response systems. China is opening-up to international dialogue, cooperation and coordination regionally and globally. China’s arrival on the international DRR landscape offers the international community new opportunities for closer policy cooperation with a particular focus on knowledge and skills exchange, international coordination and technical research collaboration

    China as a Development Actor in Southeast Asia

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    This Evidence Report identifies and explains the central factors driving China’s policies towards Southeast Asia. It examines China’s foreign relations through the perspective of foreign policy. In this context, as the title indicates, the report gathers together and evaluates the evidence on China’s role as a development actor in this neighbouring region. The study aims to contribute to evidence-based policy deliberation, formulation and implementation. It finds that, since the accession of President Xi Jinping, Southeast Asia has gained additional importance for Chinese foreign relations as a key region in China’s new ‘neighbourhood policy’ and the twenty-first century Maritime Silk Road (MSR) initiative. China’s economic cooperation and its development assistance are said (by the Chinese government) to provide investment and logistical know-how, skills and experience to undertake infrastructure capacity building in Southeast Asia. Yet the strength of Sino-regional relations is tempered by continuing tensions. These include unresolved territorial disputes, China’s unilateral action in declaring an Air Defense Identification Zone in the South China Sea, and growing concerns over weaknesses in Chinese corporate social responsibility. This report concludes that: (1) Southeast Asia’s policy portfolio would be strengthened through enhanced multilateral and national economic diversification strategies; (2) Sino-regional development partnerships can draw upon the new post-2015 global development agenda to strengthen trilateral cooperation; and (3) civil society should be engaged as a full partner in policy determination.UK Department for International Developmen

    miR-375 gene dosage in pancreatic β-cells: implications for regulation of β-cell mass and biomarker development

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    MicroRNAs play a crucial role in the regulation of cell growth and differentiation. Mice with genetic deletion of miR-375 exhibit impaired glycemic control due to decreased β-cell and increased α-cell mass and function. The relative importance of these processes for the overall phenotype of miR-375KO mice is unknown. Here, we show that mice overexpressing miR-375 exhibit normal β-cell mass and function. Selective re-expression of miR-375 in β-cells of miR-375KO mice normalizes both, α- and β-cell phenotypes as well as glucose metabolism. Using this model, we also analyzed the contribution of β-cells to the total plasma miR-375 levels. Only a small proportion (≈1 %) of circulating miR-375 originates from β-cells. Furthermore, acute and profound β-cell destruction is sufficient to detect elevations of miR-375 levels in the blood. These findings are supported by higher miR-375 levels in the circulation of type 1 diabetes (T1D) subjects but not mature onset diabetes of the young (MODY) and type 2 diabetes (T2D) patients. Together, our data support an essential role for miR-375 in the maintenance of β-cell mass and provide in vivo evidence for release of miRNAs from pancreatic β-cells. The small contribution of β-cells to total plasma miR-375 levels make this miRNA an unlikely biomarker for β-cell function but suggests a utility for the detection of acute β-cell death for autoimmune diabetes
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