9 research outputs found
Postnatal growth and cardiometabolic profile in young adults born large for gestational age
No full textContext the association between large for gestational age (LGA) phenotype, postnatal growth and cardiometabolic risk (CMR) in adult life remains unclear. the role of IGF1 genotype on LGA-related outcomes in adult life is unknown.Aim To assess the postnatal growth, IGF-I levels, CMR and the influence of the 737.738 IGF1 in adults born LGA.Subjects Case-control study (n = 515) nested in a population-based prospective cohort (n = 2063); 117 LGA and 398 gender-matched controls appropriate for gestational age (AGA) subjects.Methods Anthropometry was evaluated at birth, at 9-10 and at 23-25 years old. At the age of 23-25 years, blood pressure (BP), glycaemia, insulinaemia, homeostasis model assessment - insulin resistance, lipids, fibrinogen, and plasma IGF-I and 737.738 IGF1 polymorphism were assessed.Results Large for gestational age subjects remained heavier and taller than AGA at 9-10 and 23-25 years (P < 0.05); at 23-25 years, LGA had greater waist circumference (WC; P < 0.05) and higher BP (P < 0.05) than controls. Body proportionality at birth did not predict metabolic outcome. LGA subjects presenting catch-down of weight in childhood had lower body mass index (BMI; P = 0.001), lower WC (P < 0.05) and lower BP (P < 0.05) at 2325 years. 737.738 IGF-I genotype differed between groups (P < 0.001). Homozygosis for polymorphic alleles was associated with increased odds of LGA (OR: 3.2; 95% CI: 1.5-6.9), higher IGF-I (56.9 +/- 16.4 vs 37.7 +/- 16.0 nm; P < 0.01) and lower BP (114/68 vs 121/73 mmHg; P < 0.05).Conclusions Young adults born LGA presented higher BMI, WC and BP and appear to be at higher CMR risk than AGA subjects. the 737.738 IGF1 polymorphism appears to play a role on birth size and LGA-related metabolic outcomes.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ São Paulo, Sch Med Ribeirao Preto, Dept Pediat, BR-14091900 São Paulo, BrazilUniv São Paulo, Sch Med Ribeirao Preto, Dept Internal Med, BR-14091900 São Paulo, BrazilFAPESP: 06/50570-4FAPESP: 07/58105-1Web of Scienc
Being born large for gestational age is associated with earlier pubertal take-off and longer growth duration: a longitudinal study
No full textVitamin D, parathormone, and insulin resistance in children born large for gestational age
No full textBirth weight influences the clinical phenotype and the metabolic control of patients with type 1 diabetes (T1D)
No full textInfants born large-for-gestational-age display slower growth in early infancy, but no epigenetic changes at birth
No full textProgression of Cardio-Metabolic Risk Factors in Subjects Born Small and Large for Gestational Age
No full textThe associations of high birth weight with blood pressure and hypertension in later life: A systematic review and meta-analysis
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