SOSIALISASI TENTANG PENANGANAN PERTAMA PADA CEDERA OLAHRAGA DI KELURAHAN UWUNG JAYA

Penulisan ini dibuat untuk memberikan pemahaman dan gambaran kepada masyarakat luas dengan cara memberi edukasi atau langkah-langkah yang tepat khususnya untuk penanganan pertama pada cedera olahraga. Karena masih banyak masyarakat di sekitar kita yang masih belum paham bagaimana cara menangani cedera yang tepat khususnya tentang penanganan pertama jika terjadi cedera pada saat berolahraga. Kegiatan ini dilakukan dalam 4 tahapan dengan total 3 kegiatan inti, dengan kurun waktu pelaksanaan 15 hari yang dimulai dari tanggal 27 Februari 2022 – 12 Maret 2022 melalui zoom meet dengan jumlah 17 peserta dan whatsapp sebagai media komunikasi serta pemberian program lanjutan dengan peserta supaya lebih mudah untuk berkoordinasi antara pelaksana kegiatan dan peserta/remaja  RT 006 dan semua kegiatan dilaksanakan secara online. Tujuan  dari program ini adalah remaja RT006 Kelurahan Uwung jaya mendapatkan pemahaman yang baik dan benar sesuai dengan teori yang diberikan tentang penanganan pertama pada cedera olahraga, adapaun hasil atau dampak dari program ini yaitu remaja RT006 menjadi tahu bagaimana cara serta langkah awal penanganan pertama jika terjadi cedera dilingkungan RT 006 Kelurahan Uwung Jaya

IRR: Grounded in history: Spring 2022, issue 26

This issue in particular has a heavy focus on history. We seek not to rewrite history but to redefine it. Our emerging scholars offer critical analysis on myths, misconceptions, and misinformation. From articles on the Italian mafia, the role of agriculture in the Middle East, to the TRIPS waiver, we use history as a lesson and as a framework to guide the future of diplomacy. At the same time that we’ve engaged with global history, the International Relations Review also has sought to shift our own trajectory. The journal has historically published a print edition every year, but in the 2021 - 2022 academic year, we’ve increased both the quality and quantity of our content. With a team of more than 100 students, the International Relations Review pushes new frontiers with a podcast, blog, and journal

IRR: Redefining resistance: Fall 2021, issue 25

Since 2009, the International Relations Review has contributed to the breadth of international scholarship through a bi-annual publication written and edited by Boston University's undergraduate students. Founded with the intention of promoting dialogue between students, scholars, and policy-makers in an increasingly globalized world, the platform that the IRR creates for emerging scholars is needed now more than ever. The traditional lenses of understanding international relations have shifted in the decade that separates this issue from the first. From anti- government demonstrations and far-right nationalism to the implications of climate change and the global pandemic, the past twelve years have illuminated the extent to which technology and social mobilization have redefined resistance for the generations to come. Despite the unique hardships posed by the global pandemic, the 25th edition preserves the IRR's commitment to illuminating key currents in international affairs that are often neglected by global media. This issue seeks to explore the role of resistance in promoting political reform, thwarting suppression, and accelerating solutions to the world's most pressing crises, whether through the coffeehouses of Egypt or the colonial histories of Latin America

The Effect of Income on Mortality: Evidence from the Social Security Notch

Legislation in the 1970s created a Notch in social security payments, with those born after January 1, 1917, receiving sharply lower benefits. Using restricted-use versions of the National Mortality Detail File combined with Census data, we use this quasi experiment to examine the income mortality link in an elderly population. Estimates from difference-in-difference and regression discontinuity models show the higher-income group has a statistically significantly higher mortality rate, contradicting the previous literature. We also found that younger cohorts responded to lower incomes by increasing postretirement work effort, suggesting that moderate employment has beneficial health effects for the elderly. Copyright by the President and Fellows of Harvard College and the Massachusetts Institute of Technology.

Transient cell-in-cell formation underlies tumor relapse and resistance to immunotherapy

Despite the remarkable successes of cancer immunotherapies, the majority of patients will experience only partial response followed by relapse of resistant tumors. While treatment resistance has frequently been attributed to clonal selection and immunoediting, comparisons of paired primary and relapsed tumors in melanoma and breast cancers indicate that they share the majority of clones. Here, we demonstrate in both mouse models and clinical human samples that tumor cells evade immunotherapy by generating unique transient cell-in-cell structures, which are resistant to killing by T cells and chemotherapies. While the outer cells in this cell-in-cell formation are often killed by reactive T cells, the inner cells remain intact and disseminate into single tumor cells once T cells are no longer present. This formation is mediated predominantly by IFNγ-activated T cells, which subsequently induce phosphorylation of the transcription factors signal transducer and acti-vator of transcription 3 (STAT3) and early growth response-1 (EGR-1) in tumor cells. Indeed, inhib-iting these factors prior to immunotherapy significantly improves its therapeutic efficacy. Overall, this work highlights a currently insurmountable limitation of immunotherapy and reveals a previously unknown resistance mechanism which enables tumor cells to survive immune-mediated killing without altering their immunogenicity

A Dangerous Method: How Mali Lost Control of the North, and Learned to Stop Worrying

This article analyses changes and failures in the northern Mali system of security governance, taking into account the period running from the declaration of the Malian Third Republic (1992) to the present. Considering northern Mali as an area of limited statehood, the article develops a comparative diachronic analysis, distinguishing between three phases, namely Militiarisation (1992–2002), Fragmentation (2002–2012) and Multiplication (2013–ongoing). For every phase the focus is on (1) the mechanisms of coordination among actors, (2) the distribution of coercive capacities and ruling power and (3) the forms of authority. Unintended consequences and collective problems are highlighted, in order to understand the current situation of insecurity in the area