Hofmannsthal Jahrbuch zur Europäischen Moderne

Das Hofmannsthal-Jahrbuch ist weltweit das wichtigste Organ der Hofmannsthal-Forschung. Es bietet neben der Veröffentlichung bisher unpublizierter Briefwechsel Beiträge namhafter Wissenschaftler zur europäischen Kultur der Moderne. Inhalt: - Christine Lubkoll / Michael Ott: in memoriam Gerhard Neumann - Noch mehr Hungerkünstler und eine kleine Prosa. Mitgeteilt von Ursula Renner - Elsbeth Dangel-Pelloquin: »Wunderbare Fügung«. Heinrich Zimmer als Nachlassverwalter Hofmannsthals - Katharina Geiser: Geschichten wie aus dem Roman. Heinrich und Christiane Zimmer, Eugen und Mila Esslinger - Mathias Mayer: Die Komik des Scheiterns. Dimensionen eines Existenzialismus bei Hofmannsthal - Cristina Fossaluzza: »Ein Hauch von Mystizismus«: Hofmannsthals Scheitern an Goldoni in der Komödie »Cristinas Heimreise« - Steffen Burk: Die Welt als Wille und Vorstellung: Zur Schopenhauer-Rezeption Richard Beer-Hofmanns in »Der Tod Georgs« - Franz-Josef Deiters: »gebrochenen Zuständen ein ungebrochenes Weltverhältnis gegenüberzustellen« – Max Reinhardts und Hugo von Hofmannsthals Theater der Stimmung - Jürgen Daiber: Therapeutisches Scheitern: Freud, das Kokain und die Literatur - Inka Mülder-Bach: »Das geht gut«, »das wird gut«: Dynamiken des Scheiterns im »Andreas«-Fragment - Gregor Streim: »Ausgleich von Revolution und Tradition«. Hofmannsthals ambivalentes Verhältnis zum ›Berliner‹ Theater in den zwanziger Jahre - Stephan Kraft: Hugo von Hofmannsthals »Unbestechlicher« als Geist der Komödie - Juliane Vogel: Komische Schwärme. Zur Poiesis des Sozialen bei Hugo von Hofmannsthal - Elsbeth Dangel-Pelloquin: Hofmannsthal 1968. Zur Gründung der Hofmannsthal-Gesellschaft vor 50 Jahre

Structural and kinetic basis for heightened immunogenicity of T cell vaccines

Analogue peptides with enhanced binding affinity to major histocompatibility class (MHC) I molecules are currently being used in cancer patients to elicit stronger T cell responses. However, it remains unclear as to how alterations of anchor residues may affect T cell receptor (TCR) recognition. We correlate functional, thermodynamic, and structural parameters of TCR–peptide–MHC binding and demonstrate the effect of anchor residue modifications of the human histocompatibility leukocyte antigens (HLA)–A2 tumor epitope NY–ESO-1157–165–SLLMWITQC on TCR recognition. The crystal structure of the wild-type peptide complexed with a specific TCR shows that TCR binding centers on two prominent, sequential, peptide sidechains, methionine–tryptophan. Cysteine-to-valine substitution at peptide position 9, while optimizing peptide binding to the MHC, repositions the peptide main chain and generates subtly enhanced interactions between the analogue peptide and the TCR. Binding analyses confirm tighter binding of the analogue peptide to HLA–A2 and improved soluble TCR binding. Recognition of analogue peptide stimulates faster polarization of lytic granules to the immunological synapse, reduces dependence on CD8 binding, and induces greater numbers of cross-reactive cytotoxic T lymphocyte to SLLMWITQC. These results provide important insights into heightened immunogenicity of analogue peptides and highlight the importance of incorporating structural data into the process of rational optimization of superagonist peptides for clinical trials

A statistical learning strategy for closed-loop control of fluid flows

This work discusses a closed-loop control strategy for complex systems utilizing scarce and streaming data. A discrete embedding space is first built using hash functions applied to the sensor measurements from which a Markov process model is derived, approximating the complex system’s dynamics. A control strategy is then learned using reinforcement learning once rewards relevant with respect to the control objective are identified. This method is designed for experimental configurations, requiring no computations nor prior knowledge of the system, and enjoys intrinsic robustness. It is illustrated on two systems: the control of the transitions of a Lorenz’63 dynamical system, and the control of the drag of a cylinder flow. The method is shown to perform well

Effects of Pentachloronitrobenzene and Some of Its Known and Possible Metabolites on Fungi

Fungicidal activities of pentachloronitrobenzene and derivatives were tested with Candida albicans, Aspergillus fumigatus, Trichophyton rubrum, Trichophyton mentagrophytes, and Microsporon canis. In relation to pentachloronitrobenzene, no increasing fungistatic activities were found with cysteine derivatives. Rising fungistatic activities were seen with pentachlorophenylmethylsulfone and, in some of the strains, with pentachloronitrosobenzene, pentachlorothiophenol, pentachlorophenol, pentachloroaniline, pentachlorophenylmethylsulfoxide, the isomeric tetrachloronitrobenzenes, tetrachlorothiophenols, tetrachlorophenols, and tetrachloroanilines