National Study on Carless and Special Needs Evacuation Planning: Case Studies

The National Study of Carless and Special Needs Evacuation Planning has constructed an essential outline for carless and special needs evacuation planning. This outline is built from planning efforts in each of the five case study cities. Each city had its strengths and weaknesses. In this study, we have combined the strengths from every city involved to build the criteria used to evaluate their planning efforts. In this sense, we have based our evaluations upon real planning efforts that can and are being done around the United States

The National Study on Carless and Special Needs Evacuation Planning: Government and Non-Profit Focus Group Results

This report summarizes focus groups, conducted during the fall of 2007 on the topic of carless and special needs evacuation planning, each with government officials and non-profit organizations in Chicago, Miami, New Orleans, New York and San Francisco. Groups were asked questions on challenges, strengths and resources; cross-jurisdictional relationships; and evacuation training and planning

The National Study on Carless and Special Needs Evacuation Planning: Government and Non-Profit Focus Group Results

This report summarizes focus groups, conducted during the fall of 2007 on the topic of carless and special needs evacuation planning, each with government officials and non-profit organizations in Chicago, Miami, New Orleans, New York and San Francisco. Groups were asked questions on challenges, strengths and resources; cross-jurisdictional relationships; and evacuation training and planning

Ground-state van der Waals forces in planar multilayer magnetodielectrics

Within the frame of lowest-order perturbation theory, the van der Waals potential of a ground-state atom placed within an arbitrary dispersing and absorbing magnetodielectric multilayer system is given. Examples of an atom situated in front of a magnetodielectric plate or between two such plates are studied in detail. Special emphasis is placed on the competing attractive and repulsive force components associated with the electric and magnetic matter properties, respectively, and conditions for the formation of repulsive potential walls are given. Both numerical and analytical results are presented.Comment: 16 pages, 8 figures, minor correction

Explicit Evidence Systems with Common Knowledge

Justification logics are epistemic logics that explicitly include justifications for the agents' knowledge. We develop a multi-agent justification logic with evidence terms for individual agents as well as for common knowledge. We define a Kripke-style semantics that is similar to Fitting's semantics for the Logic of Proofs LP. We show the soundness, completeness, and finite model property of our multi-agent justification logic with respect to this Kripke-style semantics. We demonstrate that our logic is a conservative extension of Yavorskaya's minimal bimodal explicit evidence logic, which is a two-agent version of LP. We discuss the relationship of our logic to the multi-agent modal logic S4 with common knowledge. Finally, we give a brief analysis of the coordinated attack problem in the newly developed language of our logic

A peptide from the staphylococcal protein Efb binds P-selectin and inhibits the interaction of platelets with leukocytes

Aims: P-selectin is a key surface adhesion molecule for the interaction of platelets with leukocytes. We have shown previously that the N-terminal domain of Staphylococcus aureus extracellular fibrinogen-binding protein (Efb) binds to P-selectin and interferes with platelet-leukocyte aggregate formation. Here, we aimed to identify the minimal Efb motif required for binding platelets and to characterize its ability to interfering with the formation of platelet-leukocyte aggregates. Methods and Results: Using a library of synthetic peptides, we mapped the platelet-binding site to a continuous 20 amino acid stretch. The peptide Efb68-87 was able to bind to resting and, to a greater extent, thrombin-stimulated platelets in the absence of fibrinogen. Dot blots, pull-down assays and P-selectin glycoprotein ligand-1 (PSGL-1) competitive binding experiments identified P-selectin as the cellular docking site mediating Efb68-87 platelet binding. Accordingly, Efb68-87 did not bind to other blood cells and captured platelets from human whole blood under low shear stress conditions. Efb68-87 did not affect platelet activation as tested by aggregometry, flow cytometry and immunoblotting, but inhibited the formation of platelet-leukocyte aggregates (PLAs). Efb68-87 also interfered with the platelet-dependent stimulation of neutrophil extracellular traps (NETs) formation in vitro. Conclusions: We have identified Efb68-87 as a novel selective platelet-binding peptide. Efb68-87 binds directly to P-selectin and inhibits interactions of platelets with leukocytes that lead to PLA and NET formation. As PLAs and NETs play a key role in thromboinflammation, Efb68-87 is an exciting candidate for the development of novel selective inhibitors of the proinflammatory activity of platelets

Proteomics : A Tool to Study Platelet Function

Acknowledgments: Authors acknowledge Laxmikanth Kollipara for the critical review and Julia Lill for support with figures preparation. The Figure 2 was created in Biorender.Peer reviewedPublisher PD

Fucino palaeo-lake: Towards the Palaeoenvironmental history of the last 430 Ka

© 2010 AIQUA - Associazione Italiana per lo Studio del Quaternario e EMMEVI - Servizio Congressi SPA. The sedimentary succession deposited in Fucino palaeo-lake potentially records the environmental history of the Central Mediterranean Region continuously since the early Pleistocene and up to recent historical times. Fucino palaeo-lake sediments are interbedded with numerous volcanic ash layers which allow the reconstruction a robust and independent chronological framework of past environment changes. This framework is a fundamental tool to synchronise different archives at a regional and extra-regional scale and to better understand the spatio-temporal climate variability in the Quaternary at the orbital and millennial-scales. Here we present new preliminary data for the last five glacial to interglacial cycles