595 research outputs found
Spectrum of the Schr\"odinger operator in a perturbed periodically twisted tube
We study Dirichlet Laplacian in a screw-shaped region, i.e. a straight
twisted tube of a non-circular cross section. It is shown that a local
perturbation which consists of "slowing down" the twisting in the mean gives
rise to a non-empty discrete spectrum.Comment: LaTeX2e, 10 page
A Hardy inequality in twisted waveguides
We show that twisting of an infinite straight three-dimensional tube with
non-circular cross-section gives rise to a Hardy-type inequality for the
associated Dirichlet Laplacian. As an application we prove certain stability of
the spectrum of the Dirichlet Laplacian in locally and mildly bent tubes.
Namely, it is known that any local bending, no matter how small, generates
eigenvalues below the essential spectrum of the Laplacian in the tubes with
arbitrary cross-sections rotated along a reference curve in an appropriate way.
In the present paper we show that for any other rotation some critical strength
of the bending is needed in order to induce a non-empty discrete spectrum.Comment: LaTeX, 20 page
Problemas de coordenação motora em crianças de 4 a 8 anos: levantamento baseado no relato de professores
The term developmental coordination Disorder (DCD) is still new in Brazil and most of the children with this type of problems are not diagnosed. Motor coordination difficulties usually are observed at school, and although complaints about children with handwriting problems or motor awkwardness are quite common, these difficulties are not identified as a problem that deserves special attention. The objective of this study was to examine the frequency and in which activities do teachers observe motor coordination problems among children ages 4 to 8 years old. A simple questionnaire, with direct questions, was sent to schools of the metropolitan region of Belo Horizonte. Data from 288 questionnaires, 148 from teachers of public schools and 140 from private schools, were analyzed descriptively. The majority of the teachers, 88% from the public schools and 79% from the private ones, reported that they usually observe one or two students with motor coordination problems in each class they teach, which resulted in an overall estimate of 18,6% children with some sort of motor difficulty. This result exceeds the 6% reported in the international literature; therefore, it is important to invest in epidemiological studies and in the correct identification of DCD among the Brazilian children.O termo transtorno do desenvolvimento da coordenação (TDC) ainda é pouco usado no Brasil e a maioria das crianças com esse tipo de problema não é diagnosticada. As dificuldades de coordenação motora geralmente são evidenciadas na escola e, embora queixas de crianças com problemas de escrita ou lentidão motora sejam comuns, essas dificuldades não são identificadas como uma questão que merece atenção especial. O objetivo deste estudo foi examinar a freqüência e as atividades nas quais professores observam dificuldades de coordenação motora em crianças de 4 a 8 anos de idade. Um questionário simples, com questões fechadas, foi enviado a escolas da região metropolitana de Belo Horizonte. Dados de 288 questionários, sendo 148 de professores da rede Municipal e 140 de escolas particulares, foram analisados descritivamente. A maioria dos professores, 88% nas escolas Municipais e 79% nas particulares, indicaram que geralmente observam problemas de coordenação em um a dois alunos em cada classe, o que resultou na estimativa de 18,6% de crianças com algum tipo de dificuldade motora. Estes dados superam os 6% reportados na literatura internacional, sendo importante investir em estudos epidemiológicos e na identificação correta do TDC em crianças brasileiras
Electronic Coherence Dephasing in Excitonic Molecular Complexes: Role of Markov and Secular Approximations
We compare four different types of equations of motion for reduced density
matrix of a system of molecular excitons interacting with thermodynamic bath.
All four equations are of second order in the linear system-bath interaction
Hamiltonian, with different approximations applied in their derivation. In
particular we compare time-nonlocal equations obtained from so-called
Nakajima-Zwanzig identity and the time-local equations resulting from the
partial ordering prescription of the cummulant expansion. In each of these
equations we alternatively apply secular approximation to decouple population
and coherence dynamics from each other. We focus on the dynamics of intraband
electronic coherences of the excitonic system which can be traced by coherent
two-dimensional spectroscopy. We discuss the applicability of the four
relaxation theories to simulations of population and coherence dynamics, and
identify features of the two-dimensional coherent spectrum that allow us to
distinguish time-nonlocal effects.Comment: 14 pages, 8 figure
Can programme theory be used as a 'translational tool’ to optimise health service delivery in a national early years’ initiative in Scotland: a case study
Background
Theory-based evaluation (TBE) approaches are heralded as supporting formative evaluation by facilitating increased use of evaluative findings to guide programme improvement. It is essential that learning from programme implementation is better used to improve delivery and to inform other initiatives, if interventions are to be as effective as they have the potential to be. Nonetheless, few studies describe formative feedback methods, or report direct instrumental use of findings resulting from TBE. This paper uses the case of Scotland’s, National Health Service, early years’, oral health improvement initiative (Childsmile) to describe the use of TBE as a framework for providing feedback on delivery to programme staff and to assess its impact on programmatic action.<p></p>
Methods
In-depth, semi-structured interviews and focus groups with key stakeholders explored perceived deviations between the Childsmile programme 'as delivered’ and its Programme Theory (PT). The data was thematically analysed using constant comparative methods. Findings were shared with key programme stakeholders and discussions around likely impact and necessary actions were facilitated by the authors. Documentary review and ongoing observations of programme meetings were undertaken to assess the extent to which learning was acted upon.<p></p>
Results
On the whole, the activities documented in Childsmile’s PT were implemented as intended. This paper purposefully focuses on those activities where variation in delivery was evident. Differences resulted from the stage of roll-out reached and the flexibility given to individual NHS boards to tailor local implementation. Some adaptations were thought to have diverged from the central features of Childsmile’s PT, to the extent that there was a risk to achieving outcomes. The methods employed prompted national service improvement action, and proposals for local action by individual NHS boards to address this.<p></p>
Conclusions
The TBE approach provided a platform, to direct attention to areas of risk within a national health initiative, and to agree which intervention components were 'core’ to its hypothesised success. The study demonstrates that PT can be used as a 'translational tool’ to facilitate instrumental use of evaluative findings to optimise implementation within a complex health improvement programme.<p></p>
Near-field examination of perovskite-based superlenses and superlens-enhanced probe-object coupling
A planar slab of negative index material works as a superlens with
sub-diffraction-limited imaging resolution, since propagating waves are focused
and, moreover, evanescent waves are reconstructed in the image plane. Here, we
demonstrate a superlens for electric evanescent fields with low losses using
perovskites in the mid-infrared regime. The combination of near-field
microscopy with a tunable free-electron laser allows us to address precisely
the polariton modes, which are critical for super-resolution imaging. We
spectrally study the lateral and vertical distributions of evanescent waves
around the image plane of such a lens, and achieve imaging resolution of
wavelength/14 at the superlensing wavelength. Interestingly, at certain
distances between the probe and sample surface, we observe a maximum of these
evanescent fields. Comparisons with numerical simulations indicate that this
maximum originates from an enhanced coupling between probe and object, which
might be applicable for multifunctional circuits, infrared spectroscopy, and
thermal sensors.Comment: 20 pages, 6 figures, published as open access article in Nature
Communications (see http://www.nature.com/ncomms/
Propagating Quantum Microwaves: Towards Applications in Communication and Sensing
The field of propagating quantum microwaves has started to receive
considerable attention in the past few years. Motivated at first by the lack of
an efficient microwave-to-optical platform that could solve the issue of secure
communication between remote superconducting chips, current efforts are
starting to reach other areas, from quantum communications to sensing. Here, we
attempt at giving a state-of-the-art view of the two, pointing at some of the
technical and theoretical challenges we need to address, and while providing
some novel ideas and directions for future research. Hence, the goal of this
paper is to provide a bigger picture, and -- we hope -- to inspire new ideas in
quantum communications and sensing: from open-air microwave quantum key
distribution to direct detection of dark matter, we expect that the recent
efforts and results in quantum microwaves will soon attract a wider audience,
not only in the academic community, but also in an industrial environment
Is Mn-Bound Substrate Water Protonated in the S2 State of Photosystem II?
In spite of great progress in resolving the geometric structure of the water-splitting Mn4OxCa cluster in photosystem II, the binding sites and modes of the two substrate water molecules are still insufficiently characterized. While time-resolved membrane-inlet mass spectrometry measurements indicate that both substrate water molecules are bound to the oxygen-evolving complex (OEC) in the S2 and S3 states (Hendry and Wydrzynski in Biochemistry 41:13328–13334, 2002), it is not known (1) if they are both Mn-bound, (2) if they are terminal or bridging ligands, and (3) in what protonation state they are bound in the different oxidation states Si (i = 0, 1, 2, 3, 4) of the OEC. By employing 17O hyperfine sublevel correlation (HYSCORE) spectroscopy we recently demonstrated that in the S2 state there is only one (type of) Mn-bound oxygen that is water exchangeable. We therefore tentatively identified this oxygen as one substrate ‘water’ molecule, and on the basis of the finding that it has a hyperfine interaction of about 10 MHz with the electron spin of the Mn4OxCa cluster, we suggest that it is bound as a Mn–O–Mn bridge within a bis-μ2 oxo-bridged unit (Su et al. in J Am Chem Soc 130:786–787, 2008). Employing pulse electron paramagnetic resonance, 1H/2H Mims electron-nuclear double resonance and 2H-HYSCORE spectroscopies together with 1H/2H-exchange here, we test this hypothesis by probing the protonation state of this exchangeable oxygen. We conclude that this oxygen is fully deprotonated. This result is discussed in the light of earlier reports in the literature
Natural Variation in the Thermotolerance of Neural Function and Behavior due to a cGMP-Dependent Protein Kinase
Although it is acknowledged that genetic variation contributes to individual differences in thermotolerance, the specific genes and pathways involved and how they are modulated by the environment remain poorly understood. We link natural variation in the thermotolerance of neural function and behavior in Drosophila melanogaster to the foraging gene (for, which encodes a cGMP-dependent protein kinase (PKG)) as well as to its downstream target, protein phosphatase 2A (PP2A). Genetic and pharmacological manipulations revealed that reduced PKG (or PP2A) activity caused increased thermotolerance of synaptic transmission at the larval neuromuscular junction. Like synaptic transmission, feeding movements were preserved at higher temperatures in larvae with lower PKG levels. In a comparative assay, pharmacological manipulations altering thermotolerance in a central circuit of Locusta migratoria demonstrated conservation of this neuroprotective pathway. In this circuit, either the inhibition of PKG or PP2A induced robust thermotolerance of neural function. We suggest that PKG and therefore the polymorphism associated with the allelic variation in for may provide populations with natural variation in heat stress tolerance. for's function in behavior is conserved across most organisms, including ants, bees, nematodes, and mammals. PKG's role in thermotolerance may also apply to these and other species. Natural variation in thermotolerance arising from genes involved in the PKG pathway could impact the evolution of thermotolerance in natural populations
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