Primeiro relato de ototoxicidade pelo antimoniato de meglumina

Introdução: Antimoniais pentavalentes são os fármacos de primeira escolha no tratamento da leishmaniose tegumentar. Dados de ototoxicidade relacionados a tais fármacos são escassos na literatura, o que nos levou a desenvolver um estudo de funções cócleo-vestibulares. Relato de caso: Relatamos caso de paciente masculino de 78 anos com leishmaniose tegumentar, que apresentou aumento significativo dos limiares auditivos com zumbido e tontura rotatória grave durante o tratamento com antimoniato de meglumina. Os sintomas pioraram até duas semanas após a interrupção do tratamento. Conclusão: Tontura e zumbido já tinham sido associados ao antimoniato de meglumina. Entretanto, este é o primeiro caso bem documentado de toxicidade cócleo-vestibular relacionado ao antimoniato de meglumina.Introduction: Pentavalent antimonials are the first drug of choice in the treatment of tegumentary leishmaniasis. Data on ototoxicity related with such drugs is scarcely available in literature, leading us to develop a study on cochleovestibular functions. Case Report: A case of a tegumentary leishmaniasis patient, a 78-year-old man who presented a substantial increase in auditory threshold with tinnitus and severe rotatory dizziness during the treatment with meglumine antimoniate, is reported. These symptoms worsened in two weeks after treatment was interrupted. Conclusion: Dizziness and tinnitus had already been related to meglumine antimoniate. However, this is the first well documented case of cochlear-vestibular toxicity related to meglumine antimoniate

As crianças apresentam sinais e sintomas que compõem um quadro pós-COVID-19?

OBJECTIVES: To carry out a systematic review of the clinical manifestations of long-term COVID in children. METHODS: The starting point was: “What are the clinical manifestations in children with long-term COVID syndrome?”. A systematic literature review was conducted in SCOPUS, Embase, NCBI, and MedRxiv databases. Articles on the clinical picture of long-term COVID in the pediatric population were included, with the cohort, case-control, cross-sectional studies, and case reports published in 2020 and 2021. The selection and analysis were performed by four researchers independently, following the Preferred Reporting Items for Systematic Reviewers and Meta-analysis guidelines. RESULTS: Reviewers identified 6,279 potential articles, of which 8 met the inclusion criteria. The sampling in the selected publications ranged from 1 to 2,500 participants, whose age range ranged from 3 months to 18 years. The most reported symptoms in long-term COVID were: fatigue, upper and lower respiratory tract symptoms, sleep disturbances, and neurological symptoms. The duration of these symptoms ranged from four weeks to eight months. Some articles also reported pediatric inflammatory multisystem syndrome (SIM-P) in the long-term COVID. CONCLUSION: Long-term COVID affects on average 15.5% of children after infection, lasting from 4 to 32 weeks. The main symptoms were fatigue and dyspnea, followed by musculoskeletal, respiratory, neurological, and sleep disorders. Furthermore, it was impossible to elucidate these cases risk factors and outcomes in this study

A experiência de alunos do PET-Saúde com a saúde indígena e o programa Mais Médicos

O Programa PET-Saúde foi lançado em 2009 e é uma iniciativa para melhorar o ensino, mediante práticas de promoção em saúde. O PET-Saúde Indígena faz parte desse contexto e é composto por um grupo de acadêmicos dos cursos da saúde da Universidade Federal do Tocantins, Brasil, com supervisão de preceptores. O grupo realiza ações nas aldeias no Município de Tocantínia, na comunidade indígena Akwẽ-Xerente. Esse povo vem sofrendo redução em sua população, além do crescente aumento do uso de álcool e de doenças crônicas. Em 2013, O Ministério da Saúde lançou o programa Mais Médicos a fim de garantir o aumento de médicos em regiões prioritárias, e as aldeias em estudo foram incluídas. Dessa maneira, o artigo aborda a experiência dos acadêmicos de medicina no contato com esses profissionais por meio das atividades de ação em saúde nas aldeias

A experiência de alunos do PET-Saúde com a saúde indígena e o programa Mais Médicos

O Programa PET-Saúde foi lançado em 2009 e é uma iniciativa para melhorar o ensino, mediante práticas de promoção em saúde. O PET-Saúde Indígena faz parte desse contexto e é composto por um grupo de acadêmicos dos cursos da saúde da Universidade Federal do Tocantins, Brasil, com supervisão de preceptores. O grupo realiza ações nas aldeias no Município de Tocantínia, na comunidade indígena Akwẽ-Xerente. Esse povo vem sofrendo redução em sua população, além do crescente aumento do uso de álcool e de doenças crônicas. Em 2013, O Ministério da Saúde lançou o programa Mais Médicos a fim de garantir o aumento de médicos em regiões prioritárias, e as aldeias em estudo foram incluídas. Dessa maneira, o artigo aborda a experiência dos acadêmicos de medicina no contato com esses profissionais por meio das atividades de ação em saúde nas aldeias

Oilfield wastewater treatment by combined microfiltration and biological processes

10 p. : il.This work deals with the treatment of offshore oilfield wastewater from the Campos Basin (Rio de Janeiro State, Brazil). After coarse filtration, this high saline wastewater was microfiltrated through mixed cellulose ester (MCE) membranes, resultingin average removals of COD, TOC, O&G and phenols of 35%, 25%, 92% and 35%, respectively. The permeate effluent was fed into a 1-L air-lift reactor containingpolystyrene particles of 2mm diameter, used as support material. This reactor was operated for 210 days, at three hydraulic retention times (HRT): 48, 24 and 12 h. Even when operated at the lowest HRT (12 h), removal efficiencies of 65% COD, 80% TOC, 65% phenols and 40% ammonium were attained. The final effluent presented COD and TOC values of 230 and 55 mg/L, respectively. Results obtained by gas chromatography analyses and toxicity tests with Artemia salina showed that a significant improvement in the effluent’s quality was achieved after treatment by the combined (microfiltration/biological) process. r 2001 Elsevier Science Ltd. All rights reserved

Immunologic Diagnosis of Endemic Mycoses

The endemic mycoses blastomycosis, coccidioidomycosis, histoplasmosis, paracoccidioidomycosis, cryptococcosis, sporotrichosis, talaromycosis, adiaspiromycosis, and emergomycosis are mostly caused by geographically limited thermally dimorphic fungi (except for cryptococcosis), and their diagnoses can be challenging. Usual laboratory methods involved in endemic mycoses diagnosis include microscopic examination and culture of biological samples; however, serologic, histopathologic, and molecular techniques have been implemented in the last few years for the diagnosis of these mycoses since the recovery and identification of their etiologic agents is time-consuming and lacks in sensitivity. In this review, we focus on the immunologic diagnostic methods related to antibody and antigen detection since their evidence is presumptive diagnosis, and in some mycoses, such as cryptococcosis, it is definitive diagnosis

Alterations in evoked otoacoustic emissions by the use of meglumine antimoniate in American tegumentary leishmaniasis patients

Submitted by Janaína Nascimento ([email protected]) on 2019-07-19T13:50:23Z No. of bitstreams: 1 ve_Bezerra_Débora_etal_INI_2017.pdf: 1274540 bytes, checksum: ea37b81d1d5c8c29cc86661f270e23ef (MD5)Approved for entry into archive by Janaína Nascimento ([email protected]) on 2019-07-19T14:16:29Z (GMT) No. of bitstreams: 1 ve_Bezerra_Débora_etal_INI_2017.pdf: 1274540 bytes, checksum: ea37b81d1d5c8c29cc86661f270e23ef (MD5)Made available in DSpace on 2019-07-19T14:16:29Z (GMT). No. of bitstreams: 1 ve_Bezerra_Débora_etal_INI_2017.pdf: 1274540 bytes, checksum: ea37b81d1d5c8c29cc86661f270e23ef (MD5) Previous issue date: 2017Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Federal University of Rio de Janeiro. Faculty of Medicine. Department of Otorhinolaryngology and Ophthalmology. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Federal University of Rio de Janeiro. Faculty of Medicine. Department of Otorhinolaryngology and Ophthalmology. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Federal University of Rio de Janeiro. Faculty of Medicine. Department of Otorhinolaryngology and Ophthalmology. Rio de Janeiro, RJ, Brazil.Federal University of the State of the Rio de Janeiro. Faculty of Medicine. Department of Otorhinolaryngology. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Brazilian National Council for Scientific and Technological Development. Brasilia, DF, Brazil / Carlos Chagas Filho Foundation for Research Support of the state of Rio de Janeiro. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Federal University of Rio de Janeiro. Faculty of Medicine. Department of Otorhinolaryngology and Ophthalmology. Rio de Janeiro, RJ, Brazil / Carlos Chagas Filho Foundation for Research Support of the state of Rio de Janeiro. Rio de Janeiro, RJ, Brazil / New University of Lisbon. Hygiene and Tropical Medicine Institute. Lisbon, Portugal.Tegumentary Leishmaniasis (TL) is a neglected, non-contagious, infectious disease, caused by different protozoa species of the Leishmania genus that affects skin and mucous membranes. Meglumine Antimoniate (MA), the first drug of choice for TL treatment in Brazil, has already been associated with cochlear toxicity, which is defined as damages of the cochlea caused by exposure to chemical substances, resulting in reversible or irreversible hearing loss. Auditory monitoring for cochlear toxicity aims at the early detection of auditory disorders, enabling, when possible, hearing to be preserved or an early auditory rehabilitation. Although otoacoustic emissions (OAEs) are used in this monitoring, there is no consensus on the criteria that define cochlear toxicity by this examination. The objective of this study was to describe the characteristics of the OAEs in cochlear toxicity monitoring in TL patients using MA

First report on ototoxicity of meglumine antitoniate

Submitted by Rodrigo Senorans ([email protected]) on 2015-06-22T17:24:56Z No. of bitstreams: 1 First report on ototoxicity of meglumine antimoniate.pdf: 213538 bytes, checksum: 184df8c110fae2c8f71c695a84988b1b (MD5)Approved for entry into archive by Anderson Silva ([email protected]) on 2015-06-22T19:10:31Z (GMT) No. of bitstreams: 1 First report on ototoxicity of meglumine antimoniate.pdf: 213538 bytes, checksum: 184df8c110fae2c8f71c695a84988b1b (MD5)Approved for entry into archive by Anderson Silva ([email protected]) on 2015-06-26T16:20:22Z (GMT) No. of bitstreams: 1 First report on ototoxicity of meglumine antimoniate.pdf: 213538 bytes, checksum: 184df8c110fae2c8f71c695a84988b1b (MD5)Made available in DSpace on 2015-06-29T15:29:12Z (GMT). No. of bitstreams: 1 First report on ototoxicity of meglumine antimoniate.pdf: 213538 bytes, checksum: 184df8c110fae2c8f71c695a84988b1b (MD5) Previous issue date: 2014FAPERJ, CNPqFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Departamento de Otorrino e Oftalmologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Departamento de Otorrino e Oftalmologia. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Departamento de Otorrino e Oftalmologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Departamento de Otorrino e Oftalmologia. Rio de Janeiro, RJ, Brasil /Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Departamento de Otorrino e Oftalmologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilPentavalent antimonials are the first drug of choice in the treatment of tegumentary leishmaniasis. Data on ototoxicity related with such drugs is scarcely available in literature, leading us to develop a study on cochleovestibular functions. Case Report: A case of a tegumentary leishmaniasis patient, a 78-year-old man who presented a substantial increase in auditory threshold with tinnitus and severe rotatory dizziness during the treatment with meglumine antimoniate, is reported. These symptoms worsened in two weeks after treatment was interrupted. Conclusion: Dizziness and tinnitus had already been related to meglumine antimoniate. However, this is the first well documented case of cochlear-vestibular toxicity related to meglumine antimoniate