Pendekatan Ekologis Dan Tektonika Bahan Pada Perancangan Galeri Seni Ketukangan

Arsitektur di nusantara saat ini lebih mengedepankan ‘tren\u27 modern dan kurang mempertimbangkan seni ketukangan dengan aspek lokal dalam berkarya sehingga identitas arsitektur nusantara semakin terkikis dan budaya/kearifan lokal bukan lagi menjadi pertimbangan utama para penggiat arsitektur dalam merancang. Perancangan objek ini berusaha untuk meningkatkan kemampuan para tukang agar terus berinovasi dalam mencipta serta mengenalkan potensi ketukangan lokal kepada masyarakat umum. Dengan mengeksplorasi potensi alam dan ketukangan menggunakan pendekatan arsitektur ekologis kedalam objek rancang Galeri Seni Ketukangan diharapkan dapat melestarikan identitas kelokalan arsitektur nusantara serta para tukang di masa depan dapat terus berinovasi dalam berkarya dan dapat menarik antusias masyarakat terutama para penggiat arsitektur untuk kembali menerapkan aspek budaya lokal nusantara dalam mencipta karya. Objek rancang mewadahi kegiatan eksplorasi ketukangan untuk melestarikan identitas serta potensi material arsitektur di nusantara. Metoda desain yang akan digunakan adalah metoda desain William M. Pena & Steven A. Pharsall dengan pendekatan ekologis guna meminimalisir dampak objek rancang terhadap lahan dan lingkungan

Exercise stress testing enhances blood coagulation and impairs fibrinolysis in asymptomatic aortic valve stenosis

AbstractBackgroundIncreased thrombin formation and fibrin deposition on the valves were observed in patients with severe aortic valve stenosis (AS). Exercise enhances blood coagulation and fibrinolysis in healthy subjects, but its haemostatic effects in AS are unknown. We sought to investigate how stress echocardiography alters blood coagulation and fibrinolysis in AS patients free of significant atherosclerotic vascular disease.MethodsWe studied 32 consecutive asymptomatic moderate-to-severe AS patients and 32 age- and sex-matched controls. We measured peak thrombin generated using calibrated automated thrombogram, clot lysis time (CLT), and fibrinolytic markers at four time points, i.e. at rest, at peak exercise, and 1h and 24h after a symptom-limited exercise test.ResultsWe observed that peak thrombin generated rose at peak exercise to 25% higher value in the patients than in controls (p<0.001) and reached its highest level 24h from exercise in AS patients while it decreased post-exercise in controls. Baseline CLT was 13% longer in AS patients (p=0.006) and associated with thrombin activatable fibrinolysis inhibitor (TAFI) activity (r=0.69, p<0.001), antiplasmin (r=0.47, p=0.007), and plasminogen (r=−0.55, p=0.001). In AS, CLT remained unaltered at peak exercise, while it decreased in controls, yielding the intergroup difference of 28% (p<0.001). Twenty-four hours after exercise CLT became 15% longer in AS patients (p<0.001). This hypofibrinolytic effect followed a similar pattern observed for TAFI activity.ConclusionsAsymptomatic moderate-to-severe AS patients respond to exercise with more pronounced and prolonged increase in thrombin generation, together with impaired fibrinolysis as compared to controls. Repeated episodes of exercise-induced prothrombotic state in AS might contribute to the progression of this disease

Exercise-induces changes during symptom-limited exercise on a bicycle ergometer in 32 asymptomatic aortic valve stenosis patients (AS) and 32 well-matched Controls (C) in Interleukin- 10 (IL-10).

<p>Exercise-induces changes during symptom-limited exercise on a bicycle ergometer in 32 asymptomatic aortic valve stenosis patients (AS) and 32 well-matched Controls (C) in Interleukin- 10 (IL-10).</p

Exercise-induces changes during symptom-limited exercise on a bicycle ergometer in 32 asymptomatic aortic valve stenosis patients (AS) and 32 well-matched Controls (C) in HGF (hepatocyte growth factor).

<p>Exercise-induces changes during symptom-limited exercise on a bicycle ergometer in 32 asymptomatic aortic valve stenosis patients (AS) and 32 well-matched Controls (C) in HGF (hepatocyte growth factor).</p

Clinical, exercise and echocardiographic data.

<p>Clinical, exercise and echocardiographic data.</p

Exercise-induces changes during symptom-limited exercise on a bicycle ergometer in 32 asymptomatic aortic valve stenosis patients (AS) and 32 well-matched Controls (C) in VEGF (vascular endothelial growth factor).

<p>Exercise-induces changes during symptom-limited exercise on a bicycle ergometer in 32 asymptomatic aortic valve stenosis patients (AS) and 32 well-matched Controls (C) in VEGF (vascular endothelial growth factor).</p