Kerr-effect-based quantum logical gates in decoherence-free subspace

Efficient implementations of two (or three) qubit logical gates are critical for the large-scale realization of quantum computation in decoherence-free subspace (DFS) immune to the influence of decoherence effect. In this paper, we propose some schemes for setting up a family of quantum control gates, including controlled-NOT (CNOT), Toffoli, and Fredkin gates for two or three logical qubits by means of cross-Kerr nonlinearities in DFS. These three logical gates require neither complicated quantum computational circuits nor auxiliary photons (or entangled states). The success probabilities of three logical gates are approximate unit by performing the corresponding classical feed-forward operations based on the different measuring results of the X homodyne detectors, and their fidelities are robust against the photon loss with the current technology.The proposed logical gates rely on only simple linear-optics elements, available single qubit operations, and mature measurement methods, making our proposed gates be feasible and efficient in practical applications.Comment: 11 pages, 9 figure

Expression of Human Granulocyte-Macrophage Colony-Stimulating Factor in Stably-Transformed BmN and Sf-9 Cells and Silkworms by a Non-Transposon Vector

TesisEsta tesis se titula "Cambio de ruta de transporte del mineral para mejorar la producción en la mina Catalina Huanca Sociedad Minera S.A.C", y tiene como objetivo la factibilidad de la reducción de los costos operativos en la empresa minera, aplicando para ello estándares óptimos de trabajo en el sistema de transporte que se realiza, mejorando de esta manera todo el ciclo de minado, éxito que se logra con un sistema de control y medición exhaustiva de la operación de transporte y que se sintetizan en la supervisión y capacitación continua en lo concerniente a la aplicación de estándares óptimos de trabajo en la operación. El desarrollo inicial de este trabajo expone un seguimiento al actual sistema de transporte que se realiza en la unidad minera, se analizarán los factores que afectan la productividad de la operación de transporte, los métodos de trabajo, y los sistemas de control, a este análisis acompañaremos una propuesta de solución a la actividad que genera un mayor tiempo improductivo en el proceso, obteniéndose un diagnóstico de la situación operacional mediante la supervisión y colaboradores de la empresa minera. La siguiente etapa consiste en la construcción de la rampa Saynocca para cambiar la ruta de transporte de mineral, el cual cambiará la ruta de transporte para mejorar la producción de la unidad minera Catalina Huanca S.A.C. Finalmente se exponen los beneficios que se obtienen con la nueva ruta de transporte reduciendo principalmente la distancia de transporte con una longitud de 16.46 Km a una de 5.8 Km, lo cual significa una reducción considerable del 64.76%, con ello optimizando todo el sistema de transporte de mineral, teniendo como beneficio un ahorro de 119,785.14$ mensual por el transporte de mineral

N′-(2-Hydr­oxy-5-chloro­benzyl­idene)-4-nitro­benzohydrazide methanol solvate

The title compound, C14H10ClN3O4·CH4O, was synthesized from the reaction of 5-chloro­salicylaldehyde with 4-nitro­benzohydrazide in methanol. The Schiff base mol­ecule is nearly planar, with a dihedral angle of 9.1 (3)° between the two benzene rings. The methanol solvent mol­ecules are linked to the Schiff base mol­ecules by N—H⋯O, O—H⋯N and O—H⋯O hydrogen bonds, forming chains running parallel to the a axis

Clinical Study of Restless Leg Syndrome Accompanied by Psychological Symptoms Induced by High-Dose Treatment With Madopar

Objectives: Some neurological disorders demonstrate indistinguishable psychological symptoms at an early stage, especially when accompanied by jitters similar to those in Parkinson’s disease. During dopamine replacement therapy, some patients display restless leg syndrome (RLS)-like symptoms. Therefore, we aimed to analyze treatment strategies and the prognosis of RLS caused by high-dose Madopar.Methods: Nine patients who were misdiagnosed with Parkinson’s disease, taking a high dose of Madopar, and showed symptoms of anxiety, depression, and somatization were recruited. Clinical data were collected, and strategies of treatment and prognosis were analyzed.Results: Seven patients demonstrated varying degrees of anxiety and depression, and the other two cases were misdiagnosed as Parkinson’s disease. During Madopar treatment, patients gradually showed aggravated symptoms, including swelling, numbness, pain, and other sensory abnormalities in both lower extremities, which spread to both upper extremities in a few patients. Among the seven patients, symptoms of anxiety, depression, insomnia, and somatization significantly worsened during the observation period. The average time from taking Madopar to the appearance of RLS was 2.6 ± 0.6 months, the average time to clinical diagnosis was 18.17 ± 9.40 months, and the average dosage of Madopar was 1.44 ± 0.21 g per day. Gradually reducing the Madopar dosage and administering a small dose of long-acting dopamine preparation greatly alleviated the symptoms after 3 months.Conclusion: A high dose of Madopar can cause RLS-like symptoms accompanied by anxiety, depression, insomnia, and other mental health symptoms. These symptoms should be more closely monitored by clinicians

rs5911 and rs3842788 Genetic Polymorphism, Blood Stasis Syndrome, and Plasma TXB2 and hs-CRP Levels Are Associated with Aspirin Resistance in Chinese Chronic Stable Angina Patients

The identification of single nucleotide polymorphisms (SNPs) related to aspirin resistance (AR) is of great significance for the explanation why some individuals demonstrate an incomplete response to aspirin and for optimizing the antiplatelet therapy strategy. The study was designed to investigate the possible associated genetic markers and clinical factors of AR for Chinese patients with chronic stable angina after PCI and to analyze the association between TXA2, PGI2, hs-CRP level, AR, and gene polymorphisms. Totally 207 chronic stable angina patients who received 100 mg maintenance dose daily of aspirin for more than 7 days were enrolled. The inhibition of platelets was assessed using light transmittance aggregometry. TXB2, 6-keto-PGF1 , and hs-CRP were measured by radioimmunoassay. Genotyping was performed using Taqman probe technique (rs5787 and rs5911) and gene sequencing technology (rs3842788). By using binary logistic regression analysis, the impact of clinical and genetic determinants on AR was evaluated. The prevalence of AR and aspirin semiresistance (ASR) was 3.86% and 20.76%, respectively, in Chinese chronic stable angina patients. rs5911 A/C and C/C versus A/A genotype (OR = 5.546, 95% CI = 1.812-11.404), rs3842788 A/G versus G/G genotype (OR = 8.358, 95% CI = 2.470-28.286), and blood stasis syndrome (BSS, OR = 10.220, 95% CI = 4.242-24.621) were associated with AR, but rs5787 variants were all homozygous of G/G genotype. Plasma TXB2 and hs-CRP increased significantly in AR and ASR group, while 6-keto-PGF1 showed no difference, and TXB2 level was significantly higher in carriers of the rs3842788 A/G genotype. According to our results, rs5911 and rs3842788 are proved to be specific genetic markers of AR in Chinese chronic stable angina patients for the first time, and BSS was also proved to be a remarkable determinant for AR. The AR and ASR patients were with increased plasma TXB2 and hs-CRP levels, and the TXB2 level was influenced by the variation of rs3842788 genotype

Screening of traditional Chinese medicines with therapeutic potential on chronic obstructive pulmonary disease through inhibiting oxidative stress and inflammatory response

NADP(H): quinone oxidoreductase (QR) inducing effects of 38 bioactive TCM extracts in hepa 1c1c7 cells. The QR inducing effect was determined after 24h treatment of the hepa 1c1c7 cells in the presence or absence of tested TCMs. The data of the untreated control group was normalized as 1, and then the QR inducing activity of tested extracts was represented by the maximum folds of QR inducing activity (MQI) compared with the untreated control group. Sulforaphane (SF, 2.0 μM) was used as a positive control. The data are reported the means ± SD from three independent experiments. Figure S2. Inhibitory effects on NO production of 55 bioactive TCM extracts in RAW 264.7 cells. The NO concentration in the RAW 264.7 cell culture media was determined through the Griess reaction 24 h after treated in the presence or absence of tested TCMs and lipopolysaccharides (LPS, 1.0 μg/mL). Didox (100 μM) was adopted as a positive control. The data are reported the means ± SD from three independent experiments. The maximum inhibition rates (MIRs) of NO production under the untoxic tested concentration were calculated by comparing the decreased NO concentration in TCM-treated group with that in LPS-stimulated group. Table S1. TCM extracts with QR inducing activity and/or NO inhibitory effect. (DOCX 4312 kb

Monoamine oxidase A suppresses hepatocellular carcinoma metastasis by inhibiting the adrenergic system and its transactivation of EGFR signaling

Background & AimsMonoamine oxidase A (MAOA), a catecholamine neurotransmitter degrading enzyme, is closely associated with neurological and psychiatric disorders. However, its role in cancer progression remains unknown.MethodsHepatocellular carcinoma (HCC) tissue arrays (n=254) were used to investigate the correlation between MAOA expression and clinicopathological findings. In vitro invasion and anoikis assays, and in vivo intrahepatic and lung metastasis models were used to determine the role of MAOA in HCC metastasis. Quantitative real-time PCR, western blotting, immunohistochemical staining and HPLC analysis were performed to uncover the mechanism of MAOA in HCC.ResultsWe found that MAOA expression was significantly downregulated in 254 clinical HCC samples and was closely correlated with cancer vasoinvasion, metastasis, and poor prognoses. We then demonstrated that MAOA suppressed norepinephrine/epinephrine (NE/E)-induced HCC invasion and anoikis inhibition, and uncovered that the effects of NE/E on HCC behaviors were primarily mediated through alpha 1A (ADRA1A) and beta 2 adrenergic receptors (ADRB2). In addition to the canonical signaling pathway, which is mediated via adrenergic receptors (ADRs), we found that ADR-mediated EGFR transactivation was also involved in NE-induced HCC invasion and anoikis inhibition. Notably, we found that MAOA could synergize with EGFR inhibitors or ADR antagonists to abrogate NE-induced HCC behaviors.ConclusionsTaken together, the results of our study may provide insights into the application of MAOA as a novel predictor of clinical outcomes and indicate that increasing MAOA expression or enzyme activity may be a new approach that can be used for HCC treatment