Noncollinearity-modulated electronic properties of the monolayer CrI3_3

Introducing noncollinear magnetization into a monolayer CrI$_3$ is proposed to be an effective approach to modulate the local electronic properties of the two-dimensional (2D) magnetic material. Using first-principles calculation, we illustrate that both the conduction and valence bands in the monolayer CrI$_3$ are lowered down by spin spiral states. The distinct electronic structure of the monolayer noncollinear CrI$_3$ can be applied in nanoscale functional devices. As a proof of concept, we show that a magnetic domain wall can form a one-dimensional conducting channel in the 2D semiconductor via proper gating. Other possible applications such as electron-hole separation and identical quantum dots are also discussed

Personalized Financial News Recommendation Algorithm Based on Ontology

AbstractTo deal with the challenge of information overload, in this paper, we propose a financial news recommendation algorithm which help users find the articles that are interesting to read. To settle the ambiguity problem, a new presented OF-IDF method is employed to represent the unstructured text data in the form of key concepts, synonyms and synsets which are all stored in the domain ontology. For users, the recommendation algorithm build the profiles based on their behaviors to detect the genuine interests and predict current interests automatically and in real time by applying the thinking of relevance feedback. Finally, the experiment conducted on a financial news dataset demonstrates that the proposed algorithm significantly outperforms the performance of a traditional recommender

Flash-Aware Page Replacement Algorithm

Due to the limited main memory resource of consumer electronics equipped with NAND flash memory as storage device, an efficient page replacement algorithm called FAPRA is proposed for NAND flash memory in the light of its inherent characteristics. FAPRA introduces an efficient victim page selection scheme taking into account the benefit-to-cost ratio for evicting each victim page candidate and the combined recency and frequency value, as well as the erase count of the block to which each page belongs. Since the dirty victim page often contains clean data that exist in both the main memory and the NAND flash memory based storage device, FAPRA only writes the dirty data within the victim page back to the NAND flash memory based storage device in order to reduce the redundant write operations. We conduct a series of trace-driven simulations and experimental results show that our proposed FAPRA algorithm outperforms the state-of-the-art algorithms in terms of page hit ratio, the number of write operations, runtime, and the degree of wear leveling

Mutations associated with no durable clinical benefit to immune checkpoint blockade in Non-S-Cell lung cancer

(1) Background: The immune checkpoint blockade (ICB) has shown promising efficacy in non-small-cell lung cancer (NSCLC) patients with significant clinical benefits and durable responses, but the overall response rate to ICBs is only 20%. The lack of responsiveness to ICBs is currently a central problem in cancer immunotherapy. (2) Methods: Four public cohorts comprising 2986 patients with NSCLC were included in the study. We screened 158 patients with NSCLC with no durable clinical benefit (NDB) to ICBs in the Rizvi cohort and identified NDB-related gene mutations in these patients using univariate and multivariate Cox regression analyses. Programmed death-ligand 1 (PD-L1) expression, tumor mutation burden (TMB), neoantigen load, tumor-infiltrating lymphocytes, and immune-related gene expression were analyzed for identifying gene mutations. A comprehensive predictive classifier model was also built to evaluate the efficacy of ICB therapy. (3) Results: Mutations in FAT1 and KEAP1 were found to correlate with NDB in patients with NSCLC to ICBs; however, the analysis suggested that only mutation in FAT1 was valuable in predicting the efficacy of ICB therapy, and that mutation in KEAP1 acted as a prognostic but not a predictive biomarker for NSCLC. Mutations in FAT1 were associated with a higher TMB and lower multiple lymphocyte infiltration, including CD8 (T-Cell Surface Glycoprotein CD8)+ T cells. We established a prognostic model according to PD-L1 expression, TMB, smoking status, treatment regimen, treatment type, and FAT1 mutation, which indicated good accuracy by receiver operating characteristic (ROC) analysis (area under the curve (AUC) for 6-months survival: 0.763; AUC for 12-months survival: 0.871). (4) Conclusions: Mutation in FAT1 may be a predictive biomarker in patients with NSCLC who exhibit NDB to ICBs. We proposed an FAT1 mutation-based model for screening more suitable NSCLC patients to receive ICBs that may contribute to individualized immunotherapy.info:eu-repo/semantics/publishedVersio

Electro- and photon-induced cooling in BNT-BT-SBET relaxors with in situ optical temperature sensing

A novel lead-free luminescent ferroelectric (FE) ceramic, Bi0.5Na0.5TiO3-0.06BaTiO3-0.055Sr0.7Bi0.18Er0.02□0.1TiO3, is developed with an adiabatic temperature change (ΔT) of 0.7 K under an electric-field (E) of 60 kV/cm at room temperature (RT), an anti-stokes fluorescence (FL) cooling and a maximum optical T sensitivity of 0.0055 K-1 at 522 K. Interestingly, the electrocaloric (EC) response reaches a saturation at permittivity-shoulder T of 100 oC, meanwhile the maximized emission intensity of 2H11/2→4I15/2 occurs. T- and E-tunable enhancement of 2H11/2→4I15/2 emission intensity is due to the population inversion from the 4S3/2 to 2H11/2 states caused by an incoherent regime consisting of FE phase and polar nanoregions (PNRs) in a relaxor (R) matrix