Arsaalkenes R-As=C(NMe2)(2) [R = PhC(O), 4-EtC6H4C(O), 2,4,6-Me3C6H2C(O), t-BuC(O), Me3Si]: Versatile reagents in the chemistry of heterocumulenes

Weber L, Bayer P, Braun T, Stammler H-G, Neumann B. Arsaalkenes R-As=C(NMe2)(2) [R = PhC(O), 4-EtC6H4C(O), 2,4,6-Me3C6H2C(O), t-BuC(O), Me3Si]: Versatile reagents in the chemistry of heterocumulenes. Organometallics. 2006;25(7):1786-1794.Reaction of [Cp(CO)(2)M=P=C(SiMe3)(2.)] (where M = Mo (3a), W (3b)] with 2 equiv of the arsaalkene PhC(O)As=C(NMe2)(2) afforded the metalloarsaalkenes Cp(CO)(2)M-As=C(Ph)-O-P-O-C(Ph)=As-C(SiMe3)(2) [where M= Mo (6a), W (6b)]. Small amounts of [{eta(3):eta(3)-(Me3Si)(2)CPAs-AsPC(SiMe3)(2)}- {Mo(CO)(2)Cp}(2)] (7) were formed as a minor product. Similarly, 3b and 2 equiv of 4-EtC6H4C(O)As= C(NMe2)(2) gave rise to the formation of [Cp(CO)(2)W-As=C(4-EtC6H4)-O-P-O-C(4-EtC6H4)=As- C(SiMe3)(2)] (8). However, treatment of 3a and 3b with an excess of tBuC(O)As=C(NMe2)(2) yielded cocrystals of the eta(3)-2-phospha-1,3-diarsaallyl complexes [Cp(CO)(2)M{eta(3)-tBuC(O)AsPAsC(O)tBu}] [where M = Mo (13a), W (13b)] and the eta(3)-1,2,3-triarsaallyl complexes [Cp(CO)(2)M{eta(3-)tBuC(O)AsAsAsC-(O)tBu}] [where M = Mo (14a), W (14b)] in varying ratios. Reaction of 3a with Me3SiAs=C(NMe2)(2) afforded the dinuclear 1,2-diphosphapropene complex [{eta(2):eta(2)-(Me3Si)(2)C=P-P(H)-C(H)(SiMe3)(2)}{Mo-(CO)(2)Cp}(2)] (15). The novel compounds 6a,b, 8, 13a,b, 14a,b, and 15 were characterized by means of spectroscopy (IR and H-1, C-13{H-1}, P-31 NMR). Moreover the molecular structures of 7, 8, 13a, 14a, 13b, 14b, and 15 were determined by X-ray diffraction analyses

IgE test in secretions of patients with respiratory allergy

PURPOSE OF REVIEW: IgE is a key player in multiple inflammatory airway diseases. Ample literature demonstrates its presence in mucosa of patients with allergic rhinitis (AR), local allergic rhinitis (LAR), asthma, or chronic rhinosinusitis with nasal polyposis (CRSwNP). RECENT FINDINGS: Current evidence shows that high-affinity IgE in blood stream of allergic individuals derives mainly from the mucosae. Also, mucosal synthesis of IgE can occur in the absence of systemic atopy, and may be relevant in atopic and non-atopic phenotypes of rhinitis as demonstrated in LAR. Specific IgE (sIgE) detection varies depending on technique used for sample collection and its measurement. sIgE detection is highly specific for diagnosis of LAR. Moreover, measurement of sIgE in secretions could be useful in monitoring response to allergen-specific immunotherapy in both AR and LAR phenotypes. This review will focus on recent developments in the role of IgE in respiratory diseases, and the clinical implications of its measurement in secretions

International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis

BackgroundCritical examination of the quality and validity of available allergic rhinitis (AR) literature is necessary to improve understanding and to appropriately translate this knowledge to clinical care of the AR patient. To evaluate the existing AR literature, international multidisciplinary experts with an interest in AR have produced the International Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR).MethodsUsing previously described methodology, specific topics were developed relating to AR. Each topic was assigned a literature review, evidence-based review (EBR), or evidence-based review with recommendations (EBRR) format as dictated by available evidence and purpose within the ICAR:AR document. Following iterative reviews of each topic, the ICAR:AR document was synthesized and reviewed by all authors for consensus.ResultsThe ICAR:AR document addresses over 100 individual topics related to AR, including diagnosis, pathophysiology, epidemiology, disease burden, risk factors for the development of AR, allergy testing modalities, treatment, and other conditions/comorbidities associated with AR.ConclusionThis critical review of the AR literature has identified several strengths; providers can be confident that treatment decisions are supported by rigorous studies. However, there are also substantial gaps in the AR literature. These knowledge gaps should be viewed as opportunities for improvement, as often the things that we teach and the medicine that we practice are not based on the best quality evidence. This document aims to highlight the strengths and weaknesses of the AR literature to identify areas for future AR research and improved understanding

国际过敏与鼻科学共识声明 : 变应性鼻炎

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/150599/1/ICARPrimaryAuthorCOIForms1.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/150599/2/ICARSecondaryAuthorCOIForms.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/150599/3/ICARPrimaryAuthorCOIForms2.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/150599/4/ICARAuthorCOI2017.8.15.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/150599/5/alr22073_c.pd