Criteria for generalized macroscopic and mesoscopic quantum coherence

We consider macroscopic, mesoscopic and "S-scopic" quantum superpositions of eigenstates of an observable, and develop some signatures for their existence. We define the extent, or size $S$ of a superposition, with respect to an observable \hat{x}, as being the range of outcomes of \hat{x} predicted by that superposition. Such superpositions are referred to as generalized $S$-scopic superpositions to distinguish them from the extreme superpositions that superpose only the two states that have a difference $S$ in their prediction for the observable. We also consider generalized $S$-scopic superpositions of coherent states. We explore the constraints that are placed on the statistics if we suppose a system to be described by mixtures of superpositions that are restricted in size. In this way we arrive at experimental criteria that are sufficient to deduce the existence of a generalized $S$-scopic superposition. The signatures developed are useful where one is able to demonstrate a degree of squeezing. We also discuss how the signatures enable a new type of Einstein-Podolsky-Rosen gedanken experiment.Comment: 15 pages, accepted for publication in Phys. Rev.

Validation of a bovine rectal palpation simulator for training veterinary students

No abstract available

Dynamical preparation of EPR entanglement in two-well Bose-Einstein condensates

We propose to generate Einstein-Podolsky-Rosen (EPR) entanglement between groups of atoms in a two-well Bose-Einstein condensate using a dynamical process similar to that employed in quantum optics. The local nonlinear S-wave scattering interaction has the effect of creating a spin squeezing at each well, while the tunneling, analogous to a beam splitter in optics, introduces an interference between these fields that results in an inter-well entanglement. We consider two internal modes at each well, so that the entanglement can be detected by measuring a reduction in the variances of the sums of local Schwinger spin observables. As is typical of continuous variable (CV) entanglement, the entanglement is predicted to increase with atom number, and becomes sufficiently strong at higher numbers of atoms that the EPR paradox and steering non-locality can be realized. The entanglement is predicted using an analytical approach and, for larger atom numbers, stochastic simulations based on truncated Wigner function. We find generally that strong tunnelling is favourable, and that entanglement persists and is even enhanced in the presence of realistic nonlinear losses.Comment: 15 pages, 19 figure

Tripartite entanglement from interlinked χ(2)\chi^{(2)} parametric interactions

We examine the tripartite entanglement properties of an optical system using interlinked $\chi^{(2)}$ interactions, recently studied experimentally in terms of its phase-matching properties by Bondani et al [M. Bondani, A. Allevi, E. Gevinti, A. Agliati, and A. Andreoni, arXiv:quant-ph/0604002.]. We show that the system does produce output modes which are genuinely tripartite entangled and that detection of this entanglement depends crucially on the correlation functions which are measured, with a three-mode Einstein-Podolsky-Rosen inequality being the most sensitive.Comment: 15 pages, 5 figure

Unified criteria for multipartite quantum nonlocality

Wiseman and co-workers (Phys. Rev. Lett. 98, 140402, 2007) proposed a distinction between the nonlocality classes of Bell's nonlocality, steering and entanglement based on whether or not an overseer trusts each party in a bipartite scenario where they are asked to demonstrate entanglement. Here we extend that concept to the multipartite case and derive inequalities that progressively test for those classes of nonlocality, with different thresholds for each level. This framework includes the three classes of nonlocality above in special cases and introduces a family of others.Comment: V2: corrected image display; V3: substantial changes including new proofs, arguments, and result

Minimal hepatic toxicity of Onyx-015: spatial restriction of coxsackie-adenoviral receptor in normal liver.

We administered an adenoviral vector, Onyx-015, into the hepatic artery of patients with metastatic colorectal cancer involving the liver. Thirty-five patients enrolled in this multi-institutional phase I/II trial received up to eight arterial infusions of up to 2 x 10(12) viral particles. Hepatic toxicity was the primary dose-limiting toxicity observed in preclinical models. However, nearly 200 infusions of this adenoviral vector were administered directly into the hepatic artery without significant toxicity. Therefore, we undertook this analysis to determine the impact of repeated adenoviral exposure on hepatic function. Seventeen patients were treated at our institution, providing a detailed data set on the changes in hepatic function following repeated exposure to adenovirus. No changes in hepatic function occurred with the first treatment of Onyx-015 among these patients. Transient increases in transaminase levels occurred in one patient starting with the second infusion and transient increases in bilirubin was observed in two patients starting with the fifth treatment. These changes occurred too early to be explained by viral-mediated lysis of hepatocytes. In addition, viremia was observed starting 3-5 days after the viral infusion in half of the patient, but was not associated with hepatic toxicity. To further understand the basis for the minimal hepatic toxicity of adenoviral vectors, we evaluated the replication of adenovirus in primary hepatocytes and tumor cells in culture and the expression of the coxsackie-adenoviral receptor (CAR) in normal liver and colon cancer metastatic to the liver. We found that adenovirus replicates poorly in primary hepatocytes but replicates efficiently in tumors including tumors derived from hepatocytes. In addition, we found that CAR is localized at junctions between hepatocytes and is inaccessible to hepatic blood flow. CAR is not expressed on tumor vasculature but is expressed on tumor cells. Spatial restriction of CAR to the intercellular space in normal liver and diminished replication of adenovirus in hepatocytes may explain the minimal toxicity observed following repeated hepatic artery infusions with Onyx-015

Bell inequalities for continuous-variable correlations

We derive a new class of correlation Bell-type inequalities. The inequalities are valid for any number of outcomes of two observables per each of n parties, including continuous and unbounded observables. We show that there are no first-moment correlation Bell inequalities for that scenario, but such inequalities can be found if one considers at least second moments. The derivation stems from a simple variance inequality by setting local commutators to zero. We show that above a constant detector efficiency threshold, the continuous variable Bell violation can survive even in the macroscopic limit of large n. This method can be used to derive other well-known Bell inequalities, shedding new light on the importance of non-commutativity for violations of local realism.Comment: 4 pages, 1 figure. v2: New results on detector efficiencies and macroscopic limit, new co-author, changed title and abstract, changed figure, added journal reference and DO