Flux Compactifications of M-Theory on Twisted Tori

We find the bosonic sector of the gauged supergravities that are obtained from 11-dimensional supergravity by Scherk-Schwarz dimensional reduction with flux to any dimension D. We show that, if certain obstructions are absent, the Scherk-Schwarz ansatz for a finite set of D-dimensional fields can be extended to a full compactification of M-theory, including an infinite tower of Kaluza-Klein fields. The internal space is obtained from a group manifold (which may be non-compact) by a discrete identification. We discuss the symmetry algebra and the symmetry breaking patterns and illustrate these with particular examples. We discuss the action of U-duality on these theories in terms of symmetries of the D-dimensional supergravity, and argue that in general it will take geometric flux compactifications to M-theory on non-geometric backgrounds, such as U-folds with U-duality transition functions.Comment: Latex, 47 page

Do Macroalgal Environments Leave a Geological Signature? Modern Test Case from Kaikoura, New Zealand

Brown, red and green macroalgae in modern temperate marine environments are ecosystem‐forming primary producers on rocky substrates, yet they have a poor preservation potential and few fossil examples are known from the rock record. Macroalgal forests, as carbonate producers, are largely unrecognised within the coolwater carbonate realm even though they host a wide variety of calcareous organisms with good preservational potential. Some species of molluscs, sea urchins and crustaceans only live within the understorey of macroalgal forests. These, and other, calcareous flora and fauna are the key to identification of macroalgae environments in the rock record. Modern macroalgae forests at Kaikoura, New Zealand, exhibit a clear zonation of calcareous components controlled by substrate topography, wave exposure, water depth and light penetration. The prominent live calcareous components include encrusting and foliose coralline red algae, molluscs, bryozoans, echinoderms, calcareous worms, ascidians and crustaceans, as well as sponges and other soft bodied invertebrates. The sediments accumulated beneath and adjacent to the algae at Kaikoura are bioclastic, terrigenous sands and gravels; with bioclasts of coralline algal fragments and rhodoliths, barnacles, molluscs, spirorbids and bryozoans. Although the shallow, wave exposed settings that promote growth of macroalgal forests are limited in areal extent, their contribution via skeletal carbonate may be considerable. In the rock record, terrigenous sands and gravels rich in coralline, barnacle, mollusc, and bryozoan fragments, that occur in association with hard‐substrate unconformities in a cool‐water realm, must be considered as representatives of past macroalgal environments

Superstring partition functions in the doubled formalism

Computation of superstring partition function for the non-linear sigma model on the product of a two-torus and its dual within the scope of the doubled formalism is presented. We verify that it reproduces the partition functions of the toroidally compactified type--IIA and type--IIB theories for appropriate choices of the GSO projection.Comment: 15 page

Non-geometric backgrounds, doubled geometry and generalised T-duality

String backgrounds with a local torus fibration such as T-folds are naturally formulated in a doubled formalism in which the torus fibres are doubled to include dual coordinates conjugate to winding number. Here we formulate and explore a generalisation of this construction in which all coordinates are doubled, so that the doubled space is a twisted torus, i.e. a compact space constructed from identifying a group manifold under a discrete subgroup. This incorporates reductions with duality twists, T-folds and a class of flux compactifications, together with the non-geometric backgrounds expected to arise from these through T-duality. It also incorporates backgrounds that are not even locally geometric, and suggests a generalisation of T-duality to a more general context. We discuss the effective field theory arising from such an internal sector, give a world-sheet sigma model formulation of string theory on such backgrounds and illustrate our discussion with detailed examples.Comment: 81 page

Sub-surface Expression of Sand Volcanoes in the Avon-Heathcote Estuary Induced by the Darfield Earthquake; Analog for Sedimentary Structures in the Rock Record

Among the deformation features produced in Christchurch by the September 4th Darfield Earthquake were numerous and widespread “sand volcanoes”. Most of these structures occurred in urban settings and “erupted” through a hardened surface of concrete or tarseal, or soil. Sand volcanoes were also widespread in the Avon‐ Heathcote Estuary and offered an excellent opportunity to readily examine shallow subsurface profiles and as such the potential appearance of such structures in the rock record

Environment-induced dynamical chaos

We examine the interplay of nonlinearity of a dynamical system and thermal fluctuation of its environment in the ``physical limit'' of small damping and slow diffusion in a semiclassical context and show that the trajectories of c-number variables exhibit dynamical chaos due to the thermal fluctuations of the bath.Comment: Revtex, 4 pages and 4 figure

Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts

Increasing evidence highlights that senescence plays an important role in idiopathic pulmonary fibrosis (IPF). This study delineates the specific contribution of mitochondria and the superoxide they form to the senescent phenotype of lung fibroblasts from IPF patients (IPF-LFs). Primary cultures of IPF-LFs exhibited an intensified DNA damage response (DDR) and were more senescent than age-matched fibroblasts from control donors (Ctrl-LFs). Furthermore, IPF-LFs exhibited mitochondrial dysfunction, exemplified by increases in mitochondrial superoxide, DNA, stress and activation of mTORC1. The DNA damaging agent etoposide elicited a DDR and augmented senescence in Ctrl-LFs, which were accompanied by disturbances in mitochondrial homoeostasis including heightened superoxide production. However, etoposide had no effect on IPF-LFs. Mitochondrial perturbation by rotenone involving sharp increases in superoxide production also evoked a DDR and senescence in Ctrl-LFs, but not IPF-LFs. Inhibition of mTORC1, antioxidant treatment and a mitochondrial targeting antioxidant decelerated IPF-LF senescence and/or attenuated pharmacologically induced Ctrl-LF senescence. In conclusion, increased superoxide production by dysfunctional mitochondria reinforces lung fibroblast senescence via prolongation of the DDR. As part of an auto-amplifying loop, mTORC1 is activated, altering mitochondrial homoeostasis and increasing superoxide production. Deeper understanding the mechanisms by which mitochondria contribute to fibroblast senescence in IPF has potentially important therapeutic implications

Area metric gravity and accelerating cosmology

Area metric manifolds emerge as effective classical backgrounds in quantum string theory and quantum gauge theory, and present a true generalization of metric geometry. Here, we consider area metric manifolds in their own right, and develop in detail the foundations of area metric differential geometry. Based on the construction of an area metric curvature scalar, which reduces in the metric-induced case to the Ricci scalar, we re-interpret the Einstein-Hilbert action as dynamics for an area metric spacetime. In contrast to modifications of general relativity based on metric geometry, no continuous deformation scale needs to be introduced; the extension to area geometry is purely structural and thus rigid. We present an intriguing prediction of area metric gravity: without dark energy or fine-tuning, the late universe exhibits a small acceleration.Comment: 52 pages, 1 figure, companion paper to hep-th/061213

Mutational Analysis of Hedgehog Signaling Pathway Genes in Human Malignant Mesothelioma

Background The Hedgehog (HH) signaling pathway is critical for embryonic development and adult homeostasis. Recent studies have identified regulatory roles for this pathway in certain cancers with mutations in the HH pathway genes. The extent to which mutations of the HH pathway genes are involved in the pathogenesis of malignant mesothelioma (MMe) is unknown. Methodology/Principal Findings Real-time PCR analysis of HH pathway genes PTCH1, GLI1 and GLI2 were performed on 7 human MMe cell lines. Exon sequencing of 13 HH pathway genes was also performed in cell lines and human MMe tumors. In silico programs were used to predict the likelihood that an amino-acid substitution would have a functional effect. GLI1, GLI2 and PTCH1 were highly expressed in MMe cells, indicative of active HH signaling. PTCH1, SMO and SUFU mutations were found in 2 of 11 MMe cell lines examined. A non-synonymous missense SUFU mutation (p.T411M) was identified in LO68 cells. In silico characterization of the SUFU mutant suggested that the p.T411M mutation might alter protein function. However, we were unable to demonstrate any functional effect of this mutation on Gli activity. Deletion of exons of the PTCH1 gene was found in JU77 cells, resulting in loss of one of two extracellular loops implicated in HH ligand binding and the intracellular C-terminal domain. A 3-bp insertion (69_70insCTG) in SMO, predicting an additional leucine residue in the signal peptide segment of SMO protein was also identified in LO68 cells and a MMe tumour. Conclusions/Significance We identified the first novel mutations in PTCH1, SUFU and SMO associated with MMe. Although HH pathway mutations are relatively rare in MMe, these data suggest a possible role for dysfunctional HH pathway in the pathogenesis of a subgroup of MMe and help rationalize the exploration of HH pathway inhibitors for MMe therapy