677 research outputs found
MTSS1 is a critical epigenetically regulated tumor suppressor in CML
Chronic myeloid leukemia (CML) is driven by malignant stem cells that can persist despite therapy. We have identified Metastasis suppressor 1 (Mtss1/MIM) to be downregulated in hematopoietic stem and progenitor cells from leukemic transgenic SCLtTA/Bcr-Abl mice and in patients with CML at diagnosis, and Mtss1 was restored when patients achieved complete remission. Forced expression of Mtss1 decreased clonogenic capacity and motility of murine myeloid progenitor cells and reduced tumor growth. Viral transduction of Mtss1 into lineage depleted SCLtTA/Bcr-Abl bone marrow cells decreased leukemic cell burden in recipients, and leukemogenesis was reduced upon injection of Mtss1 overexpressing murine myeloid 32D cells. Tyrosine kinase inhibitor (TKI) therapy and reversion of Bcr-Abl expression increased Mtss1 expression but failed to restore it to control levels. CML patient samples revealed higher DNA methylation of specific Mtss1 promoter CpG sites that contain binding sites for Kaiso and Rest transcription factors. In summary, we identified a novel tumor suppressor in CML stem cells that is downregulated by both Bcr-Abl kinase-dependent and -independent mechanisms. Restored Mtss1 expression markedly inhibits primitive leukemic cell biology in vivo, providing a therapeutic rationale for the Bcr-Abl-Mtss1 axis to target TKI resistant CML stem cells in patients
Recensiones [Revista de Historia Económica Año III Invierno 1985 n. 1 pp. 157-191]
Antonio Domínguez Ortiz. Política fiscal y cambio social en la España del siglo (Por Juan Zafra Oteyza). --
Guillermo Céspedes del Castillo. América Hispánica (1492-1898) (Por Zacarías Moutoukias). --
Carmelo Mesa Lago. La economía en Cuba socialista. Una evaluación de dos décadas (Por Juan Carlos Jiménez). --
Louis Henry. Manual de demografía histórica (Por David-Sven Reher). --
Ezequiel Gallo. La Pampa Gringa (Por Carlos Rodríguez Braun). --
Javier García Fernández. El origen del Municipio Constitucional: Autonomía y Centralización en Francia y España (Por Concepción de Castro). --
David E. Vassberg. La venta de tierras baldías. El comunitarismo agrario y la Corona de Castilla durante el siglo XVI (Por Bartolomé Yun Casalilla). --
José Manuel Mutiloa. Guipúzcoa en el siglo XIX (Por Luis Castells). --
Diego Azqueta Oyarzun. Teoría económica de la acumulación socialista (Por Alfons Barceló). --
T. H. Hollingsworth. Demografía histórica (Por Francisco Bustelo). --
Ricardo Calle Sáiz. La Hacienda en la II República española (Por Juan Hernández Andréu). --
Jordi Nadal ; Carles Sudriá. Historia de la Caja de Pensiones (La «Caixa» dentro del sistema financiero catalán) (Por Rafael Castejón). --
Daniel Peña ; Nicolás Sánchez-Albornoz. Dependencia dinámica entre precios agrícolas: El trigo en España, 1857-1890. Un estudio empírico (Por Agustín Maravall).Publicad
Measurement of the Strong Coupling Constant from Inclusive Jet Production at the Tevatron Collider
We report a measurement of the strong coupling constant, ,
extracted from inclusive jet production in collisions at
1800 GeV. The QCD prediction for the evolution of with
jet transverse energy is tested over the range 40<<450 GeV using
for the renormalization scale. The data show good agreement with QCD in
the region below 250 GeV. In the text we discuss the data-theory comparison in
the region from 250 to 450 GeV. The value of at the mass of the
boson averaged over the range 40<<250 GeV is found to be
. The associated theoretical uncertainties are mainly due to the choice
of renormalization scale (^{+6%}_{-4%}) and input parton distribution
functions (5%).Comment: 7 pages, 3 figures, using RevTeX. Submitted to Physical Review
Letter
Search for Narrow Diphoton Resonances and for gamma-gamma+W/Z Signatures in p\bar p Collisions at sqrt(s)=1.8 TeV
We present results of searches for diphoton resonances produced both
inclusively and also in association with a vector boson (W or Z) using 100
pb^{-1} of p\bar p collisions using the CDF detector. We set upper limits on
the product of cross section times branching ratio for both p\bar
p\to\gamma\gamma + X and p\bar p\to\gamma\gamma + W/Z. Comparing the inclusive
production to the expectations from heavy sgoldstinos we derive limits on the
supersymmetry-breaking scale sqrt{F} in the TeV range, depending on the
sgoldstino mass and the choice of other parameters. Also, using a NLO
prediction for the associated production of a Higgs boson with a W or Z boson,
we set an upper limit on the branching ratio for H\to\gamma\gamma. Finally, we
set a lower limit on the mass of a `bosophilic' Higgs boson (e.g. one which
couples only to \gamma, W, and Z$ bosons with standard model couplings) of 82
GeV/c^2 at 95% confidence level.Comment: 30 pages, 11 figure
Measurement of the p\bar{p}\sqrt{s}$ = 1.8 TeV
We update the measurement of the top production cross section using the CDF
detector at the Fermilab Tevatron. This measurement uses decays to
the final states +jets and +jets. We search for quarks from
decays via secondary-vertex identification or the identification of
semileptonic decays of the and cascade quarks. The background to the
production is determined primarily through a Monte Carlo simulation.
However, we calibrate the simulation and evaluate its uncertainty using several
independent data samples. For a top mass of 175 , we measure
pb and pb using
the secondary vertex and the lepton tagging algorithms, respectively. Finally,
we combine these results with those from other decay channels and
obtain pb.Comment: The manuscript consists of 130 pages, 35 figures and 42 tables in
RevTex. The manuscript is submitted to Physical Review D. Fixed typo in
author lis
Measurement of the Helicity of W Bosons in Top Quark Decays
We use the transverse momentum spectrum of leptons in the decay chain t-->bW
with W-->l nu to measure the helicity of the W bosons in the top quark rest
frame. Our measurement uses a ttbar sample isolated in 106 +/- 4 inverse
picobarns of data collected in ppbar collisions at sqrt(s)=1.8 TeV with the CDF
detector at the Fermilab Tevatron. Assuming a standard V--A weak decay, we find
that the fraction of W's with zero helicity in the top rest frame is F_0 = 0.91
+/- 0.37 (stat) +/- 0.13 (syst), consistent with the standard model prediction
of F_0=0.70 for a top mass of 175 GeV/c**2.Comment: Submitted to PRL. 8 pages, 2 figure
Measurement of the lepton charge asymmetry in W-boson decays produced in p-pbar collisions
We describe a measurement of the charge asymmetry of leptons from W boson
decays in the rapidity range 0 enu, munu events from
110+/-7 pb^{-1}of data collected by the CDF detector during 1992-95. The
asymmetry data constrain the ratio of d and u quark momentum distributions in
the proton over the x range of 0.006 to 0.34 at Q2 \approx M_W^2. The asymmetry
predictions that use parton distribution functions obtained from previously
published CDF data in the central rapidity region (0.0<|y_l|<1.1) do not agree
with the new data in the large rapidity region (|y_l|>1.1).Comment: 13 pages, 3 tables, 1 figur
Production of Y(1S) Mesons from chib Decays in pp(bar) Collisions at sqrt(s)=1.8 TeV
We have reconstructed the radiative decays and in collisions
at TeV, and measured the fraction of mesons
that originate from these decays. For mesons with
GeV/, the fractions that come from and
decays are and
, respectively. We have derived the fraction of
directly produced mesons to be .Comment: 13 Pages, 2 figure
Measurement of the Decay Amplitudes of B0 --> J/psi K* and B0s --> J/psi phi Decays
A full angular analysis has been performed for the pseudo-scalar to
vector-vector decays, B0 --> J/psi K* and B_s --> J/psi phi, to determine the
amplitudes for decays with parity-even longitudinal and transverse polarization
and parity-odd transverse polarization. The measurements are based on 190 B0
candidates and 40 B_s candidates collected from a data set corresponding to 89
inverse pb of pbarp collisions at root(s) = 1.8 TeV at the Fermilab Tevatron.
In both decays the decay amplitude for longitudinal polarization dominates and
the parity-odd amplitude is found to be small.Comment: 7 pages, 3 figures, 1 tabl
Search for the Supersymmetric Partner of the Top-Quark in Collisions at
We report on a search for the supersymmetric partner of the top quark (stop)
produced in events using of
collisions at recorded with the Collider Detector at
Fermilab. In the case of a light stop squark, the decay of the top quark into
stop plus the lightest supersymmetric particle (LSP) could have a significant
branching ratio. The observed events are consistent with Standard Model production and decay. Hence, we set limits on the branching ratio of
the top quark decaying into stop plus LSP, excluding branching ratios above 45%
for a LSP mass up to 40 {\rm GeV/c}.Comment: 11 pages, 4 figure
- …