Treatment of Resistant Fever: New Method of Local Cerebral Cooling

Background: Fever in neurocritical care patients is common and has a negative impact on neurological outcome. The purpose of this prospective observational study was (1) to evaluate the practicability of cooling with newly developed neck pads in the daily setting of neurointensive care unit (NICU) patients and (2) to evaluate its effectiveness as a surrogate endpoint to indicate the feasibility of neck cooling as a new method for intractable fever. Methods: Nine patients with ten episodes of intractable fever and aneurysmal subarachnoid hemorrhage were treated with one of two different shapes of specifically adapted cooling neck pads. Temperature values of the brain, blood, and urinary bladder were taken close meshed after application of the cooling neck pads up to hour8. Results: The brain, blood, and urinary bladder temperatures decreased significantly from hour0 to a minimum in hour5 (P<0.01). After hour5, instead of continuous cooling in all the patients, the temperature of all the three sites remounted. Conclusion: This study showed the practicability of local cooling for intractable fever using the newly developed neck pads in the daily setting of NICU patient

Development possibilities of small villages with an example of Mályinka

Dolgozatom Mályinka település fejlődési lehetőségeinek számbavételéről szól. Mályinka Borsod-Abaúj-Zemplén megyében, a Kazincbarcikai járásban helyezkedik el, az Északi-Bükk lábánál, gyönyörű természeti környezetben. A dolgozat első, terjedelmesebb részben Mályinka jellemzését végeztem el a vidék hármas funkciója alapján. Mályinka elemzése után bemutattam a településen Európai Uniós forrásokból megvalósult fejlesztéseket, felmértem a lakossági igényt a további fejlesztésekre, ezek alapján további fejlesztési lehetőségeket fogalmaztam meg.BSc/BAGazdasági és vidékfejlesztési agrármérnök

Treatment of resistant fever: New method of local cerebral cooling

BACKGROUND: Fever in neurocritical care patients is common and has a negative impact on neurological outcome. The purpose of this prospective observational study was (1) to evaluate the practicability of cooling with newly developed neck pads in the daily setting of neurointensive care unit (NICU) patients and (2) to evaluate its effectiveness as a surrogate endpoint to indicate the feasibility of neck cooling as a new method for intractable fever. METHODS: Nine patients with ten episodes of intractable fever and aneurysmal subarachnoid hemorrhage were treated with one of two different shapes of specifically adapted cooling neck pads. Temperature values of the brain, blood, and urinary bladder were taken close meshed after application of the cooling neck pads up to hour 8. RESULTS: The brain, blood, and urinary bladder temperatures decreased significantly from hour 0 to a minimum in hour 5 (P < 0.01). After hour 5, instead of continuous cooling in all the patients, the temperature of all the three sites remounted. CONCLUSION: This study showed the practicability of local cooling for intractable fever using the newly developed neck pads in the daily setting of NICU patients

Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients

BACKGROUN