8 research outputs found
Study - Topical lincomycin gel in acne vulgaris: A multicentric placebo controlled study
Introduction: Acne vulgaris is commonly treated with topical
antibacterials. We evaluated lincomycin gel, a new topical formulation
for mild to moderate acne. Material and Methods: A multicentric,
randomized, double blind, placebo controlled, clinical trial was
conducted with lincomycin hydrochloride in 2% gel form in 200 patients
with grade II and grade III acne. The severity of acne lesions was
noted at baseline and after 4 weeks. Results: About 70% cases in the
study group showed a good to excellent response, which was
significantly more as compared to 23% in the placebo group. The
frequency and severity of adverse reactions in the two groups were
similar. Conclusion: Lincomycin hydrochloride gel is an effective and
safe treatment option for mild to moderate acne vulgaris
Evolution of genes and genomes on the Drosophila phylogeny
Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species