Primary renal carcinoid metastasizing to distant sites 12 years after the initial diagnosis

Les carcinoïdes primitifs du rein sont rares avec une centaine de cas rapportés dans la littérature. Sur le plan histologique, il s'agit d'une tumeur bien différenciée dont la morphologie rejoint souvent celle des carcinoïdes dans les autres localisations. Nous rapportons un cas de carcinoïde primitif du rein survenant chez un homme de 41 ans, découvert à la suite de métastases hépatiques. La tumeur était particulière par son architecture tubulo-papillaire, suggérant à tort le diagnostic de carcinome papillaire du rein. Ce diagnostic a été redressé 12 ans après, à la suite de l'apparition d'autres métastases hépatiques, osseuses et pulmonaires.Pan African Medical Journal 2016; 2

Adult Granulosa Cell Tumours of the Ovary Seven Case Reports

Background:Ovarian granulosa cell tumours are low-grade malignant sex cord-stromal tumours. They represent 2 to 3% of all ovarian cancers and occur mainly within the adult population. Aim:&nbsp; to provide an updated overview on ovarian adult granulosa cell tumours.Patients Methods:in our retrospective study, we reviewed seven cases of adult granulosa cell tumours that were diagnosed at the pathology department of Mongi Slim hospital over a fourteen-year period (2002- 2015). Clinical and pathRIiological characteristics were retrospectively analyzed.Results: The patients of our series ranged in age between 39 and 64 years (mean = 53 years). The&nbsp; most&nbsp; common&nbsp; presenting&nbsp; symptom&nbsp; was&nbsp; abnormal&nbsp; uterine&nbsp; bleeding&nbsp; (n=5)&nbsp; followed&nbsp; by&nbsp; pelvic pain&nbsp; (n=4).&nbsp; All&nbsp; patients&nbsp; underwent&nbsp; surgical&nbsp; treatment&nbsp; including&nbsp; total&nbsp; hysterectomy&nbsp; with&nbsp; bilateral salpingo-oophorectomy&nbsp; (n=4),&nbsp; hysterectomy&nbsp; with&nbsp; right&nbsp; salpingo-oophorectomy&nbsp; (n=1)&nbsp; and&nbsp; salpingo-oophorectomy (n=2). Histopathological examination of the surgical specimen confirmed the diagnosis of adult granulosa cell tumour in all cases. Conclusions:Adult granulosa cell tumours of the ovary are considered as low grade malignancies with&nbsp; a&nbsp; relatively&nbsp; more&nbsp; favourable&nbsp; prognosis&nbsp; compared&nbsp; with&nbsp; much&nbsp; more&nbsp; commonly&nbsp; encountered epithelial&nbsp; ovarian tumours. A&nbsp; prolonged&nbsp; post-therapeutic&nbsp; follow-up&nbsp; is&nbsp; necessary&nbsp; because&nbsp; of&nbsp; the&nbsp; risk of recurrences.</p