6,236 research outputs found
Crucifixion and median neuropathy.
Crucifixion as a means of torture and execution was first developed in the 6th century B.C. and remained popular for over 1000 years. Details of the practice, which claimed hundreds of thousands of lives, have intrigued scholars as historical records and archaeological findings from the era are limited. As a result, various aspects of crucifixion, including the type of crosses used, methods of securing victims to crosses, the length of time victims survived on the cross, and the exact mechanisms of death, remain topics of debate. One aspect of crucifixion not previously explored in detail is the characteristic hand posture often depicted in artistic renditions of crucifixion. In this posture, the hand is clenched in a peculiar and characteristic fashion: there is complete failure of flexion of the thumb and index finger with partial failure of flexion of the middle finger. Such a "crucified clench" is depicted across different cultures and from different eras. A review of crucifixion history and techniques, median nerve anatomy and function, and the historical artistic depiction of crucifixion was performed to support the hypothesis that the "crucified clench" results from proximal median neuropathy due to positioning on the cross, rather than from direct trauma of impalement of the hand or wrist
A global magnetic anomaly map
A subset of POGO satellite magnetometer data has been formed that is suitable for analysis of crustal magnetic anomalies. Using a thirteenth order field model, fit to these data, magnetic residuals have been calculated over the world to latitude limits of plus 50 deg. These residuals averaged over one degree latitude-longitude blocks represent a detailed global magnetic anomaly map derived solely from satellite data. Preliminary analysis of the map indicates that the anomalies are real and of geological origin
CP Violation from a Higher Dimensional Model
It is shown that Randall-Sundrum model has the EDM term which violates the
CP-symmetry. The comparison with the case of Kaluza-Klein theory is done. The
chiral property, localization, anomaly phenomena are examined. We evaluate the
bulk quantum effect using the method of the induced effective action. This is a
new origin of the CP-violation.Comment: 15pages, Proc. of Int. Workshop on "Neutrino Masses and
Mixings"(Dec.17-19,2006,Univ.of Shizuoka,Japan
Rapid and efficient stable gene transfer to mesenchymal stromal cells using a modified foamy virus vector
Mesenchymal stromal cells (MSCs) hold great promise for regenerative medicine. Stable ex vivo gene transfer to MSCs could improve the outcome and scope of MSC therapy, but current vectors require multiple rounds of transduction, involve genotoxic viral promoters and/or the addition of cytotoxic cationic polymers in order to achieve efficient transduction. We describe a self-inactivating foamy virus vector (FVV), incorporating the simian macaque foamy virus envelope and using physiological promoters, which efficiently transduces murine MSCs (mMSCs) in a single-round. High and sustained expression of the transgene, whether GFP or the lysosomal enzyme, arylsulphatase A (ARSA), was achieved. Defining MSC characteristics (surface marker expression and differentiation potential), as well as long-term engraftment and distribution in the murine brain following intracerebroventricular delivery, are unaffected by FVV transduction. Similarly, greater than 95% of human MSCs (hMSCs) were stably transduced using the same vector, facilitating human application. This work describes the best stable gene transfer vector available for mMSCs and hMSCs
Microscopic Surface Structure of Liquid Alkali Metals
We report an x-ray scattering study of the microscopic structure of the
surface of a liquid alkali metal. The bulk liquid structure factor of the
eutectic K67Na33 alloy is characteristic of an ideal mixture, and so shares the
properties of an elemental liquid alkali metal. Analysis of off-specular
diffuse scattering and specular x-ray reflectivity shows that the surface
roughness of the K-Na alloy follows simple capillary wave behavior with a
surface structure factor indicative of surface induced layering. Comparison of
thelow-angle tail of the K67Na33 surface structure factor with the one measured
for liquid Ga and In previously suggests that layering is less pronounced in
alkali metals. Controlled exposure of the liquid to H2 and O2 gas does not
affect the surface structure, indicating that oxide and hydride are not stable
at the liquid surface under these experimental conditions.Comment: 12 pages, 3 figures, published in Phys. Rev.
Electron tomography at 2.4 {\AA} resolution
Transmission electron microscopy (TEM) is a powerful imaging tool that has
found broad application in materials science, nanoscience and biology(1-3).
With the introduction of aberration-corrected electron lenses, both the spatial
resolution and image quality in TEM have been significantly improved(4,5) and
resolution below 0.5 {\AA} has been demonstrated(6). To reveal the 3D structure
of thin samples, electron tomography is the method of choice(7-11), with
resolutions of ~1 nm^3 currently achievable(10,11). Recently, discrete
tomography has been used to generate a 3D atomic reconstruction of a silver
nanoparticle 2-3 nm in diameter(12), but this statistical method assumes prior
knowledge of the particle's lattice structure and requires that the atoms fit
rigidly on that lattice. Here we report the experimental demonstration of a
general electron tomography method that achieves atomic scale resolution
without initial assumptions about the sample structure. By combining a novel
projection alignment and tomographic reconstruction method with scanning
transmission electron microscopy, we have determined the 3D structure of a ~10
nm gold nanoparticle at 2.4 {\AA} resolution. While we cannot definitively
locate all of the atoms inside the nanoparticle, individual atoms are observed
in some regions of the particle and several grains are identified at three
dimensions. The 3D surface morphology and internal lattice structure revealed
are consistent with a distorted icosahedral multiply-twinned particle. We
anticipate that this general method can be applied not only to determine the 3D
structure of nanomaterials at atomic scale resolution(13-15), but also to
improve the spatial resolution and image quality in other tomography
fields(7,9,16-20).Comment: 27 pages, 17 figure
Bony ingrowth potential of 3D-printed porous titanium alloy: a direct comparison of interbody cage materials in an in vivo ovine lumbar fusion model.
Background contextThere is significant variability in the materials commonly used for interbody cages in spine surgery. It is theorized that three-dimensional (3D)-printed interbody cages using porous titanium material can provide more consistent bone ingrowth and biological fixation.PurposeThe purpose of this study was to provide an evidence-based approach to decision-making regarding interbody materials for spinal fusion.Study designA comparative animal study was performed.MethodsA skeletally mature ovine lumbar fusion model was used for this study. Interbody fusions were performed at L2-L3 and L4-L5 in 27 mature sheep using three different interbody cages (ie, polyetheretherketone [PEEK], plasma sprayed porous titanium-coated PEEK [PSP], and 3D-printed porous titanium alloy cage [PTA]). Non-destructive kinematic testing was performed in the three primary directions of motion. The specimens were then analyzed using micro-computed tomography (µ-CT); quantitative measures of the bony fusion were performed. Histomorphometric analyses were also performed in the sagittal plane through the interbody device. Outcome parameters were compared between cage designs and time points.ResultsFlexion-extension range of motion (ROM) was statistically reduced for the PTA group compared with the PEEK cages at 16 weeks (p-value=.02). Only the PTA cages demonstrated a statistically significant decrease in ROM and increase in stiffness across all three loading directions between the 8-week and 16-week sacrifice time points (p-value≤.01). Micro-CT data demonstrated significantly greater total bone volume within the graft window for the PTA cages at both 8 weeks and 16 weeks compared with the PEEK cages (p-value<.01).ConclusionsA direct comparison of interbody implants demonstrates significant and measurable differences in biomechanical, µ-CT, and histologic performance in an ovine model. The 3D-printed porous titanium interbody cage resulted in statistically significant reductions in ROM, increases in the bone ingrowth profile, as well as average construct stiffness compared with PEEK and PSP
Surface Structure of Liquid Metals and the Effect of Capillary Waves: X-ray Studies on Liquid Indium
We report x-ray reflectivity (XR) and small angle off-specular diffuse
scattering (DS) measurements from the surface of liquid Indium close to its
melting point of C. From the XR measurements we extract the surface
structure factor convolved with fluctuations in the height of the liquid
surface. We present a model to describe DS that takes into account the surface
structure factor, thermally excited capillary waves and the experimental
resolution. The experimentally determined DS follows this model with no
adjustable parameters, allowing the surface structure factor to be deconvolved
from the thermally excited height fluctuations. The resulting local electron
density profile displays exponentially decaying surface induced layering
similar to that previously reported for Ga and Hg. We compare the details of
the local electron density profiles of liquid In, which is a nearly free
electron metal, and liquid Ga, which is considerably more covalent and shows
directional bonding in the melt. The oscillatory density profiles have
comparable amplitudes in both metals, but surface layering decays over a length
scale of \AA for In and \AA for Ga. Upon controlled
exposure to oxygen, no oxide monolayer is formed on the liquid In surface,
unlike the passivating film formed on liquid Gallium.Comment: 9 pages, 5 figures; submitted to Phys. Rev.
Gaps in the cloud cover? Comparing extinction measures in spiral disks
Dust in galaxies can be mapped by either the FIR/sub-mm emission, the optical
or infrared reddening of starlight, or the extinction of a known background
source. We compare two dust extinction measurements for a set of fifteen
sections in thirteen nearby galaxies, to determine the scale of the dusty ISM
responsible for disk opacity: one using stellar reddening and the other a known
background source. In our earlier papers, we presented extinction measurements
of 29 galaxies, based on calibrated counts of distant background objects
identified though foreground disks in HST/WFPC2 images. For the 13 galaxies
that overlap with the Spitzer Infrared Nearby Galaxies Survey (SINGS), we now
compare these results with those obtained from an I-L color map. Our goal is to
determine whether or not a detected distant galaxy indicates a gap in the dusty
ISM, and hence to better understand the nature and geometry of the disk
extinction.
We find that distant galaxies are predominantly in low-extinction sections
marked by the color maps, indicating that their number depends both on the
cloud cover of {\it Spitzer}-resolved dust structures --mostly the spiral
arms--and a diffuse, unresolved underlying disk. We note that our infrared
color map (E[I-L]) underestimates the overall dust presence in these disks
severely, because it implicitly assumes the presence of a dust screen in front
of the stellar distribution.Comment: 22 pages, 2 figures, 3 tables, accepted for publication in A
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