22 research outputs found

    HandyClient - Kundeadministration af telebaseret trafik

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    Første version af HandyClient systemet, der understøtter administrationen af kunder/brugere af et kollektivt telebaseret trafiksystem, anvendes i HandyBAT trafiksystemet på Bornholm. HandyBAT's mål er samkøring af diverse sektorielle kørsels- ordninger og samtidig tilbyde et alternativt offentlig trafiksy- stem - en dør til dør betjening. Kommende versioner af HandyClient skal bidrage til en mere baseret trafiksystem, anvendes i HandyBAT trafiksystemet på Bornholm. HandyBAT's mål er samkøring af diverse sektorielle kørsels- ordninger og samtidig tilbyde et alternativt offentlig trafiksystem - en dør til dør betjening. Kommende versioner af HandyClient skal bidrage til en mere fleksibel HandyBAT ordning og for den sags skyld HandyBAT lignende trafiksystemer andre steder i Danmark. HandyClient vil også være et naturlig element i et landsdækkende telebaseret handicap-trafiksystemet

    Cortical thickness in Dutch police officers: an examination of factors associated with resilience

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    Previous neuroimaging studies on resilience have generally compared resilience and psychopathology after stress exposure, which does not allow for conclusions regarding correlates specific to resilience. The aim of the present study was to investigate resilience-specific correlates in cortical thickness and/or cortical surface area and their correlations with psychometric measurements, using a three-group design that included a non-trauma-exposed control group in order to disentangle effects related to resilience from those related to psychopathology. Structural magnetic resonance imaging scans were acquired from 82 Dutch police officers. Participants were categorized into resilient (n = 31; trauma exposure, no psychopathology), vulnerable (n = 32; trauma exposure, psychopathology), and control groups (n = 19; no trauma exposure, no psychopathology). Specific regions of interest (ROIs) were identified based on previous studies that found the rostral and caudal anterior cingulate cortex (ACC) to be implicated in trauma-related psychopathology. Cortical thickness and surface area of the ROIs-the rostral and caudal ACC-and of the whole brain were examined. No significant differences in cortical thickness or surface area were found between the resilient group and other groups in the ROI and whole-brain analyses. Thus, the results of the present study provide no evidence of an association between resilience to traumatic stress and measures of thickness and surface area in cortical regions of the brain in a sample of Dutch police officers.Stress-related psychiatric disorders across the life spa

    ENIGMA-Sleep:Challenges, opportunities, and the road map

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    Neuroimaging and genetics studies have advanced our understanding of the neurobiology of sleep and its disorders. However, individual studies usually have limitations to identifying consistent and reproducible effects, including modest sample sizes, heterogeneous clinical characteristics and varied methodologies. These issues call for a large-scale multi-centre effort in sleep research, in order to increase the number of samples, and harmonize the methods of data collection, preprocessing and analysis using pre-registered well-established protocols. The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium provides a powerful collaborative framework for combining datasets across individual sites. Recently, we have launched the ENIGMA-Sleep working group with the collaboration of several institutes from 15 countries to perform large-scale worldwide neuroimaging and genetics studies for better understanding the neurobiology of impaired sleep quality in population-based healthy individuals, the neural consequences of sleep deprivation, pathophysiology of sleep disorders, as well as neural correlates of sleep disturbances across various neuropsychiatric disorders. In this introductory review, we describe the details of our currently available datasets and our ongoing projects in the ENIGMA-Sleep group, and discuss both the potential challenges and opportunities of a collaborative initiative in sleep medicine
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