The importance of incorporating technological advancements into the artificial eye process: a perspective commentary

Application of technology into healthcare has typically been targeted to high demand illnesses and treatments. However, with an increasing need to meet patient’s expectations combined with increased accessibility and reduced costs, smaller healthcare fields are starting to investigate its function and usability. Services have historically been led by skills and expertise, and recent developments are being seen by ocularists in the field of prosthetic eyes who acknowledge the potential benefit from technological advancement. Utilising the technologies recently investigated in maxillofacial prosthesis can start the evolutionary process where products are continually re-designed and re-developed to achieve excellent patient outcome and satisfaction levels

Stochasticity of Bias and Nonlocality of Galaxy Formation: Linear Scales

If one wants to represent the galaxy number density at some point in terms of only the mass density at the same point, there appears the stochasticity in such a relation, which is referred to as ``stochastic bias''. The stochasticity is there because the galaxy number density is not merely a local function of a mass density field, but it is a nonlocal functional, instead. Thus, the phenomenological stochasticity of the bias should be accounted for by nonlocal features of galaxy formation processes. Based on mathematical arguments, we show that there are simple relations between biasing and nonlocality on linear scales of density fluctuations, and that the stochasticity in Fourier space does not exist on linear scales under a certain condition, even if the galaxy formation itself is a complex nonlinear and nonlocal precess. The stochasticity in real space, however, arise from the scale-dependence of bias parameter, $b$. As examples, we derive the stochastic bias parameters of simple nonlocal models of galaxy formation, i.e., the local Lagrangian bias models, the cooperative model, and the peak model. We show that the stochasticity in real space is also weak, except on the scales of nonlocality of the galaxy formation. Therefore, we do not have to worry too much about the stochasticity on linear scales, especially in Fourier space, even if we do not know the details of galaxy formation process.Comment: 24 pages, latex, including 2 figures, ApJ, in pres

Cosmological quintessence accretion onto primordial black holes : conditions for their growth to the supermassive scale

In this work we revisit the growth of small primordial black holes (PBHs) immersed in a quintessential field and/or radiation to the supermassive black hole (SMBHs) scale. We show the difficulties of scenarios in which such huge growth is possible. For that purpose we evaluated analytical solutions of the differential equations (describing mass evolution) and point out the strong fine tuning for that conclusions. The timescale for growth in a model with a constant quintessence flux is calculated and we show that it is much bigger than the Hubble time.The fractional gain of the mass is further evaluated in other forms, including quintessence and/or radiation. We calculate the cosmological density $\Omega$ due to quintessence necessary to grow BHs to the supermassive range and show it to be much bigger than one. We also describe the set of complete equations analyzing the evolution of the BH+quintessence universe, showing some interesting effects such the quenching of the BH mass growth due to the evolution of the background energy. Additional constraints obtained by using the Holographic Bound are also described. The general equilibrium conditions for evaporating/accreting black holes evolving in a quintessence/radiation universe are discussed in the Appendix.Comment: 21 pp., 2 Figures, To appear in IJMP

Dark Matter: Introduction

This short review was prepared as an introduction to the Royal Society's 'Dark Matter' conference. It addresses the embarrassing fact that 95% of the universe is unaccounted for. Favoured dark matter candidates are axions or weakly-interacting particles that have survived from the very early universe, but more exotic options cannot be excluded. Experimental searches are being made for the 'dark' particles but we have indirect clues to their nature too. Comparisons of data (from, eg, gravitational lensing) with numerical simulations of galaxy formation can constrain (eg) the particle velocities and collision cross sections. The mean cosmic density of dark matter (plus baryons) is now pinned down to be only about 30% of the critical density However, other recent evidence -- microwave background anisotropies, complemented by data on distant supernovae -- reveals that our universe actually is 'flat', and that its dominant ingredient (about 70% of the total mass-energy) is something quite unexpected -- 'dark energy' pervading all space, with negative pressure. We now confront two mysteries: (i) Why does the universe have three quite distinct basic ingredients -- baryons, dark matter and dark energy -- in the proportions (roughly) 5%, 25% and 70%? (ii) What are the (almost certainly profound) implications of the 'dark energy' for fundamental physics?Comment: 10 pages, 1 figure. Late

Doctors' decisions when disclosing their mental ill-health

Background Understanding of what prevents doctors from seeking help for mental ill-health has improved. However, less is known about what promotes timely disclosure and the nature of doctors’ decision making. Aims This study aimed to define how doctors make decisions about their own mental ill-health, and what facilitates disclosure. It explored the disclosure experiences of doctors and medical students; their attitudes to their decisions, and how they evaluate potential outcomes. Methods Qualitative, semi-structured interviews with UK doctors and medical students with personal experience of mental ill-health. Participants were recruited through relevant organizations, utilizing regular communications such as newsletters, e-mails and social media. Data were subject to a thematic analysis. Results Forty-six interviews were conducted. All participants had disclosed their mental ill-health to someone; not all to their workplace. Decision making was complex, with many participants facing multiple decisions throughout their careers. Disclosures were made despite the many obstacles identified in the literature; participants described enablers to and benefits of disclosing. The importance of appropriate responses to first disclosures was highlighted. Conclusions Motivations to disclose mental ill-health are complex and multifactorial. An obstacle for one was an enabler for another. Understanding this and the importance of the first disclosure has important implications for how best to support doctors and medical students in need

Sunyaev - Zel'dovich fluctuations from spatial correlations between clusters of galaxies

We present angular power spectra of the cosmic microwave background radiation anisotropy due to fluctuations of the Sunyaev-Zel'dovich (SZ) effect through clusters of galaxies. A contribution from the correlation among clusters is especially focused on, which has been neglected in the previous analyses. Employing the evolving linear bias factor based on the Press-Schechter formalism, we find that the clustering contribution amounts to 20-30% of the Poissonian one at degree angular scales. If we exclude clusters in the local universe, it even exceeds the Poissonian noise, and makes dominant contribution to the angular power spectrum. As a concrete example, we demonstrate the subtraction of the ROSAT X-ray flux-limited cluster samples. It indicates that we should include the clustering effect in the analysis of the SZ fluctuations. We further find that the degree scale spectra essentially depend upon the normalization of the density fluctuations, i.e., \sigma_8, and the gas mass fraction of the cluster, rather than the density parameter of the universe and details of cluster evolution models. Our results show that the SZ fluctuations at the degree scale will provide a possible measure of \sigma_8, while the arc-minute spectra a probe of the cluster evolution. In addition, the clustering spectrum will give us valuable information on the bias at high redshift, if we can detect it by removing X-ray luminous clusters.Comment: 11 pages, 4 figures, submitted to Astrophysical Journa

VLA Limits for Intermediate Mass Black Holes in Three Globular Clusters

The observational evidence for central black holes in globular clusters has been argued extensively, and their existence has important consequences for both the formation and evolution of the cluster. Most of the evidence comes from dynamical arguments, but the interpretation is difficult, given the short relaxation times and old ages of the clusters. One of the most robust signatures for the existence of a black hole is radio and/or X-ray emission. We observed three globular clusters, NGC6093 (M80), NGC6266 (M62), and NGC7078 (M15), with the VLA in the A and C configuration with a 3-sigma noise of 36, 36 and 25 microJy, respectively. We find no statistically-significant evidence for radio emission from the central region for any of the three clusters. NGC6266 shows a 2-sigma detection. It is difficult to infer a mass from these upper limits due to uncertainty about the central gas density, accretion rate, and accretion model.Comment: 5 pages, accepted for publication in the Astronomical Journa

Anthropic reasoning in multiverse cosmology and string theory

Anthropic arguments in multiverse cosmology and string theory rely on the weak anthropic principle (WAP). We show that the principle, though ultimately a tautology, is nevertheless ambiguous. It can be reformulated in one of two unambiguous ways, which we refer to as WAP_1 and WAP_2. We show that WAP_2, the version most commonly used in anthropic reasoning, makes no physical predictions unless supplemented by a further assumption of "typicality", and we argue that this assumption is both misguided and unjustified. WAP_1, however, requires no such supplementation; it directly implies that any theory that assigns a non-zero probability to our universe predicts that we will observe our universe with probability one. We argue, therefore, that WAP_1 is preferable, and note that it has the benefit of avoiding the inductive overreach characteristic of much anthropic reasoning.Comment: 7 pages. Expanded discussion of selection effects and some minor clarifications, as publishe

BATSE Observations of Gamma-Ray Burst Spectra. IV. Time-Resolved High-Energy Spectroscopy

We report on the temporal behavior of the high-energy power law continuum component of gamma-ray burst spectra with data obtained by the Burst and Transient Source Experiment. We have selected 126 high fluence and high flux bursts from the beginning of the mission up until the present. Much of the data were obtained with the Large Area Detectors, which have nearly all-sky coverage, excellent sensitivity over two decades of energy and moderate energy resolution, ideal for continuum spectra studies of a large sample of bursts at high time resolution. At least 8 spectra from each burst were fitted with a spectral form that consisted of a low-energy power law, a spectral break at middle energies and a high-energy continuum. In most bursts (122), the high-energy continuum was consistent with a power law. The evolution of the fitted high-energy power-law index over the selected spectra for each burst is inconsistent with a constant for 34% of the total sample. The sample distribution of the average value for the index from each burst is fairly narrow, centered on -2.12. A linear trend in time is ruled out for only 20% of the bursts, with hard-to-soft evolution dominating the sample (100 events). The distribution for the total change in the power-law index over the duration of a burst peaks at the value -0.37, and is characterized by a median absolute deviation of 0.39, arguing that a single physical process is involved. We present analyses of the correlation of the power-law index with time, burst intensity and low-energy time evolution. In general, we confirm the general hard-to-soft spectral evolution observed in the low-energy component of the continuum, while presenting evidence that this evolution is different in nature from that of the rest of the continuum.Comment: 30 pages, with 2 tables and 9 figures To appear in The Astrophysical Journal, April 1, 199