1,131 research outputs found
Reverse Transplant Tourism
In this article, we propose a novel form of kidney swap, which we label “Reverse Transplant Tourism.” This proposal has the potential to increase the number of successful transplants in the US at a time of great need, while reducing costs. It also will provide benefits to impoverished international patients with willing, compatible donors who otherwise would have no access to transplantation. Instead of non-US kidney donors being offered money through a black market middleman in exchange for one of their kidneys, Reverse Transplant Tourism would provide a legal and ethical exchange of living donor kidneys through kidney-paired donation. In this way, the donors will not receive money for their kidneys, but rather will receive a transplant for someone they love, while also helping a US pair who would otherwise be unable to transplant due to biological incompatibility
Layer guided-acoustic plate mode biosensors for monitoring MHC-peptide interactions
The transduction signals from the immobilisation of a class I heavy chain, HLA-A2, on a layer guided acoustic plate mode device, followed by binding of beta(2)-microglobulin and subsequent selective binding of a target peptide are reported
Negative vacuum energy densities and the causal diamond measure
Arguably a major success of the landscape picture is the prediction of a
small, non-zero vacuum energy density. The details of this prediction depends
in part on how the diverging spacetime volume of the multiverse is regulated, a
question that remains unresolved. One proposal, the causal diamond measure, has
demonstrated many phenomenological successes, including predicting a
distribution of positive vacuum energy densities in good agreement with
observation. In the string landscape, however, the vacuum energy density is
expected to take positive and negative values. We find the causal diamond
measure gives a poor fit to observation in such a landscape -- in particular,
99.6% of observers in galaxies seemingly just like ours measure a vacuum energy
density smaller than we do, most of them measuring it to be negative.Comment: 9 pages, 3 figures; v2: minor error fixed (results essentially
unchanged), reference added; v3: published version, includes a few
clarification
Shock fragmentation model for gravitational collapse
A cloud of gas collapsing under gravity will fragment. We present a new
theory for this process, in which layers shocked gas fragment due to their
gravitational instability. Our model explains why angular momentum does not
inhibit the collapse process. The theory predicts that the fragmentation
process produces objects which are significantly smaller than most stars,
implying that accretion onto the fragments plays an essential role in
determining the initial masses of stars. This prediction is also consistent
with the hypothesis that planets can be produced by gravitational collapse.Comment: 22 pages, 3 figure
Effects of diamagnetic levitation on bacterial growth in liquid
Diamagnetic levitation is a technique that uses a strong, spatially-varying magnetic field to levitate diamagnetic materials, such as water and biological cells. This technique has the potential to simulate aspects of weightlessness, on the Earth. In common with all ground-based techniques to simulate weightlessness, however, there are effects introduced by diamagnetic levitation that are not present in space. Since there have been few studies that systematically investigate these differences, diamagnetic levitation is not yet being fully exploited. For the first time, we critically assess the effect of diamagnetic levitation on a bacterial culture in liquid. We used a superconducting magnet to levitate growing bacterial cultures for up to 18 hours, in a series of experiments to determine the effect of diamagnetic levitation on all phases of the bacterial growth cycle. We find that diamagnetic levitation increases the rate of population growth in a liquid culture. The speed of sedimentation of the bacterial cells to the bottom of the container is considerably reduced. Further experiments and microarray gene analysis show that the growth enhancement is due to greater oxygen availability in the magnetically levitated sample. We demonstrate that the magnetic field that levitates the cells also induces convective stirring in the liquid, an effect not present in microgravity. We present a simple theoretical model, showing how the paramagnetic force on dissolved oxygen can cause the liquid to become unstable to convection when the consumption of oxygen by the bacteria generates an oxygen concentration gradient. We propose that this convection enhances oxygen availability by transporting oxygen around the sample. Since convection is absent in space, these results are of significant importance and timeliness to researchers considering using diamagnetic levitation to explore weightless effects on living organisms and a broad range of other topics in the physical and life sciences
Contending cultures of counterterrorism: transatlantic divergence or convergence?
Terrorist attacks on the United States, Spain and the United Kingdom have underlined the differing responses of Europe and the United States to the 'new terrorism'. This article analyses these responses through the prism of historically determined strategic cultures. For the last four years the United States has directed the full resources of a 'national security' approach towards this threat and has emphasized unilateralism. Europe, based on its own past experience of terrorism, has adopted a regulatory approach pursued through multilateralism. These divergences in transatlantic approaches, with potentially major implications for the future of the relationship, have appeared to be mitigated by a revised American strategy of counterterrorism that has emerged during 2005. However, this article contends that while strategic doctrines may change, the more immutable nature of strategic culture will make convergence difficult. This problem will be compounded by the fact that neither Europe nor America have yet addressed the deeper connections between terrorism and the process of globalization
Boltzmann brains and the scale-factor cutoff measure of the multiverse
To make predictions for an eternally inflating "multiverse", one must adopt a
procedure for regulating its divergent spacetime volume. Recently, a new test
of such spacetime measures has emerged: normal observers - who evolve in pocket
universes cooling from hot big bang conditions - must not be vastly outnumbered
by "Boltzmann brains" - freak observers that pop in and out of existence as a
result of rare quantum fluctuations. If the Boltzmann brains prevail, then a
randomly chosen observer would be overwhelmingly likely to be surrounded by an
empty world, where all but vacuum energy has redshifted away, rather than the
rich structure that we observe. Using the scale-factor cutoff measure, we
calculate the ratio of Boltzmann brains to normal observers. We find the ratio
to be finite, and give an expression for it in terms of Boltzmann brain
nucleation rates and vacuum decay rates. We discuss the conditions that these
rates must obey for the ratio to be acceptable, and we discuss estimates of the
rates under a variety of assumptions.Comment: 32 pp, 2 figs. Modified to conform to the version accepted by Phys.
Rev. D. The last paragraph of Sec. V-A, about Boltzmann brains in Minkowski
space, has been significantly enlarged. Two sentences were added to the
introduction concerning the classical approximation and the hope of finding a
motivating principle for the measure. Several references were adde
Decision making in kidney paired donation programs with altruistic donors
In recent years, kidney paired donation has been extended to include living non-directed or altruistic donors, in which an altruistic donor donates to the candidate of an incompatible donor candidate pair with the understanding that the donor in that pair will further donate to the candidate of a second pair, and so on; such a process continues and thus forms an altruistic donor-initiated chain. In this paper, we propose a novel strategy to sequentially allocate the altruistic donor (or bridge donor) so as to maximize the expected utility; analogous to the way a computer plays chess, the idea is to evaluate different allocations for each altruistic donor (or bridge donor) by looking several moves ahead in a derived look-ahead search tree. Simulation studies are provided to illustrate and evaluate our proposed method
BATSE Observations of Gamma-Ray Burst Spectra. IV. Time-Resolved High-Energy Spectroscopy
We report on the temporal behavior of the high-energy power law continuum
component of gamma-ray burst spectra with data obtained by the Burst and
Transient Source Experiment. We have selected 126 high fluence and high flux
bursts from the beginning of the mission up until the present. Much of the data
were obtained with the Large Area Detectors, which have nearly all-sky
coverage, excellent sensitivity over two decades of energy and moderate energy
resolution, ideal for continuum spectra studies of a large sample of bursts at
high time resolution. At least 8 spectra from each burst were fitted with a
spectral form that consisted of a low-energy power law, a spectral break at
middle energies and a high-energy continuum. In most bursts (122), the
high-energy continuum was consistent with a power law. The evolution of the
fitted high-energy power-law index over the selected spectra for each burst is
inconsistent with a constant for 34% of the total sample. The sample
distribution of the average value for the index from each burst is fairly
narrow, centered on -2.12. A linear trend in time is ruled out for only 20% of
the bursts, with hard-to-soft evolution dominating the sample (100 events). The
distribution for the total change in the power-law index over the duration of a
burst peaks at the value -0.37, and is characterized by a median absolute
deviation of 0.39, arguing that a single physical process is involved. We
present analyses of the correlation of the power-law index with time, burst
intensity and low-energy time evolution. In general, we confirm the general
hard-to-soft spectral evolution observed in the low-energy component of the
continuum, while presenting evidence that this evolution is different in nature
from that of the rest of the continuum.Comment: 30 pages, with 2 tables and 9 figures To appear in The Astrophysical
Journal, April 1, 199
Jet-Induced Emission-Line Nebulosity and Star Formation in the High-Redshift Radio Galaxy 4C41.17
The high redshift radio galaxy 4C41.17 consists of a powerful radio source in
which previous work has shown that there is strong evidence for jet-induced
star formation along the radio axis. We argue that nuclear photoionization is
not responsible for the excitation of the emission line clouds and we construct
a jet-cloud interaction model to explain the major features revealed by the
data. The interaction of a high-powered jet with a dense cloud in the halo of
4C41.17 produces shock-excited emission-line nebulosity through ~1000 km/s
shocks and induces star formation. The CIII to CIV line ratio and the CIV
luminosity emanating from the shock, imply that the pre-shock density in the
line-emitting cloud is high enough (~1-10 cm^-3) that shock initiated star
formation could proceed on a timescale of order a few x 10^6 yrs, well within
the estimated dynamical age of the radio source. Broad (FWHM ~ 100 - 1400 km/s)
emission lines are attributed to the disturbance of the gas cloud by a partial
bow--shock and narrow emission lines (FWHM ~ 500 - 650 km/s) (in particular
CIV) arise in precursor emission in relatively low metallicity gas. The implied
baryonic mass ~ 8 \times 10^{10} solar masses of the cloud is high and implies
that Milky Way size condensations existed in the environments of forming radio
galaxies at a redshift of 3.8. Our interpretation of the data provides a
physical basis for the alignment of the radio, emission-line and UV continuum
images in some of the highest redshift radio galaxies and the analysis
presented here may form a basis for the calculation of densities and cloud
masses in other high redshift radio galaxies.Comment: 18 pages, 5 figures; uses astrobib.sty and aaspp4.sty. Better
versions of figures available via anonymous from
ftp://mso.anu.edu.au:pub/pub/geoff/4C41.1
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