2,485 research outputs found

    Ethnicity and Hidradenitis Suppurativa

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    On the elliptic nonabelian Fourier transform for unipotent representations of p-adic groups

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    In this paper, we consider the relation between two nonabelian Fourier transforms. The first one is defined in terms of the Langlands-Kazhdan-Lusztig parameters for unipotent elliptic representations of a split p-adic group and the second is defined in terms of the pseudocoefficients of these representations and Lusztig's nonabelian Fourier transform for characters of finite groups of Lie type. We exemplify this relation in the case of the p-adic group of type G_2.Comment: 17 pages; v2: several minor corrections, references added; v3: corrections in the table with unipotent discrete series of G

    Graded Hecke algebras for disconnected reductive groups

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    We introduce graded Hecke algebras H based on a (possibly disconnected) complex reductive group G and a cuspidal local system L on a unipotent orbit of a Levi subgroup M of G. These generalize the graded Hecke algebras defined and investigated by Lusztig for connected G. We develop the representation theory of the algebras H. obtaining complete and canonical parametrizations of the irreducible, the irreducible tempered and the discrete series representations. All the modules are constructed in terms of perverse sheaves and equivariant homology, relying on work of Lusztig. The parameters come directly from the data (G,M,L) and they are closely related to Langlands parameters. Our main motivation for considering these graded Hecke algebras is that the space of irreducible H-representations is canonically in bijection with a certain set of "logarithms" of enhanced L-parameters. Therefore we expect these algebras to play a role in the local Langlands program. We will make their relation with the local Langlands correspondence, which goes via affine Hecke algebras, precise in a sequel to this paper.Comment: Theorem 3.4 and Proposition 3.22 in version 1 were not entirely correct as stated. This is repaired in a new appendi

    Impact of Grazing Management Strategies on Carbon Sequestration in a Semi-Arid Rangeland, USA

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    The effects of 12 years of grazing management strategies on carbon (C) distribution and sequestration were assessed on a semi-arid mixed-grass prairie in Wyoming, USA. Five grazing treatments were evaluated: non-grazed exclosures; continuous, season-long grazing at a light (22 steer-days ha-1) stocking rate; and, rotationally-deferred, short-duration rotation, and continuous, season-long grazing, all three at a heavy stocking rate (59 steer-days ha-1). Non-grazed exclosures exhibited a large buildup of dead plant material (72% of total aboveground plant matter) and forb biomass represented a large component (35%) of the plant community. Stocking rate, but not grazing strategy, changed plant community composition and decreased surface litter. Light grazing decreased forbs and increased cool-season mid-grasses, resulting in a highly diversified plant community and the highest total production of grasses. Heavy grazing increased warm-season grasses at the expense of the cool-season grasses, which decreased total forage production and opportunity for early season grazing. Compared to the exclosures, all grazing treatments resulted in significantly higher levels of C (6000-9000 kg ha-1) in the surface 15 cm of the soil. Higher levels of soil C with grazing are likely the result of faster litter decomposition and recycling, and redistribution of C within the 0-60 cm plant-soil system. Grazing at an appropriate stocking rate had beneficial effects on plant composition, forage production, and soil C sequestration. Without grazing, deterioration of the plant-soil system is indicated

    Extensions of tempered representations

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    Let π,π\pi, \pi' be irreducible tempered representations of an affine Hecke algebra H with positive parameters. We compute the higher extension groups ExtHn(π,π)Ext_H^n (\pi,\pi') explicitly in terms of the representations of analytic R-groups corresponding to π\pi and π\pi'. The result has immediate applications to the computation of the Euler-Poincar\'e pairing EP(π,π)EP(\pi,\pi'), the alternating sum of the dimensions of the Ext-groups. The resulting formula for EP(π,π)EP(\pi,\pi') is equal to Arthur's formula for the elliptic pairing of tempered characters in the setting of reductive p-adic groups. Our proof applies equally well to affine Hecke algebras and to reductive groups over non-archimedean local fields of arbitrary characteristic. This sheds new light on the formula of Arthur and gives a new proof of Kazhdan's orthogonality conjecture for the Euler-Poincar\'e pairing of admissible characters.Comment: This paper grew out of "A formula of Arthur and affine Hecke algebras" (arXiv:1011.0679). In the second version some minor points were improve

    Evidence for Neutrino Oscillations from Muon Decay at Rest

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    A search for nu_bar_mu to nu_bar_e oscillations has been conducted at the Los Alamos Meson Physics Facility using nu_bar_mu from mu+ decay at rest. The nu_bar_e are detected via the reaction (nu_bar_e,p) -> (e+,n), correlated with the 2.2 MeV gamma from (n,p) -> (d,gamma). The use of tight cuts to identify e+ events with correlated gamma rays yields 22 events with e+ energy between 36 and 60 MeV and only 4.6 (+/- 0.6) background events. The probability that this excess is due entirely to a statistical fluctuation is 4.1E-08. A chi^2 fit to the entire e+ sample results in a total excess of 51.8 (+18.7) (-16.9) (+/- 8.0) events with e+ energy between 20 and 60 MeV. If attributed to nu_bar_mu -> nu_bar_e oscillations, this corresponds to an oscillation probability (averaged over the experimental energy and spatial acceptance) of 0.0031 (+0.0011) (-0.0010) (+/- 0.0005).Comment: 57 pages, 34 figures, revtex, additional information available at http://nu1.lampf.lanl.gov/~lsnd

    Stability of Maleimide-PEG and Mono-Sulfone-PEG Conjugation to a Novel Engineered Cysteine in the Human Hemoglobin Alpha Subunit

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    In order to use a Hemoglobin Based Oxygen Carrier as an oxygen therapeutic or blood substitute, it is necessary to increase the size of the hemoglobin molecule to prevent rapid renal clearance. A common method uses maleimide PEGylation of sulfhydryls created by the reaction of 2-iminothiolane at surface lysines. However, this creates highly heterogenous mixtures of molecules. We recently engineered a hemoglobin with a single novel, reactive cysteine residue on the surface of the alpha subunit creating a single PEGylation site (βCys93Ala/αAla19Cys). This enabled homogenous PEGylation by maleimide-PEG with >80% efficiency and no discernible effect on protein function. However, maleimide-PEG adducts are subject to deconjugation via retro-Michael reactions and cross-conjugation to endogenous thiol species in vivo. We therefore compared our maleimide-PEG adduct with one created using a mono-sulfone-PEG less susceptible to deconjugation. Mono-sulfone-PEG underwent reaction at αAla19Cys hemoglobin with > 80% efficiency, although some side reactions were observed at higher PEG:hemoglobin ratios; the adduct bound oxygen with similar affinity and cooperativity as wild type hemoglobin. When directly compared to maleimide-PEG, the mono-sulfone-PEG adduct was significantly more stable when incubated at 37°C for seven days in the presence of 1 mM reduced glutathione. Hemoglobin treated with mono-sulfone-PEG retained > 90% of its conjugation, whereas for maleimide-PEG < 70% of the maleimide-PEG conjugate remained intact. Although maleimide-PEGylation is certainly stable enough for acute therapeutic use as an oxygen therapeutic, for pharmaceuticals intended for longer vascular retention (weeks-months), reagents such as mono-sulfone-PEG may be more appropriate
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