28,967 research outputs found
Revenue Ruling 77-290 - Recent Interpretations of Agency Law Inequitably Taxes Members of Religious Orders
Dubois Henri. Population et fiscalité en Bourgogne à la fin du Moyen Âge. In: Comptes rendus des séances de l'Académie des Inscriptions et Belles-Lettres, 128ᵉ année, N. 4, 1984. pp. 540-555
Necesary and sufficient range-dimension conditions for bipartite quantum correlations
Necessary and sufficient conditions for the existence of a composite-system
statistical operator, and, separately, for the possibility of its being
correlated or uncorrelated, are derived in terms of its range dimension and the
range dimensions of its reduced statistical operators.Comment: 6 pages, Latex 2
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Integrate CRISPR/Cas9 for protein expression of HLA-B*38:68Q via precise gene editing.
The determination of null- or low-expressed HLA alleles is clinically relevant in both hematopoietic stem cell transplantation and solid organ transplantation. We studied the expression level of a questionable (Q) HLA-B*38:68Q allele, which carries a 9-nucleotide (nt) deletion at codon 230-232 in exon 4 of HLA-B*38:01:01:01 using CRISPR/Cas9 gene editing technology. CRISPR/Cas9 gene editing of HLA-B*38:01:01:01 homozygous EBV B cell line resulted in one HLA-B*38:68Q/B*38:01:01:01 heterozygous and one HLA-B*38:68Q homozygous clone. Flow cytometric analysis of monoclonal anti-Bw4 antibody showed the protein expression of HLA-B*38:01:01:01 in homozygous cells was 2.2 fold higher than HLA-B*38:68Q/B*38:01:01:01 heterozygous cells, and the expression of HLA-B*38:68Q/B*38:01:01:01 heterozygous cells was over 2.0 fold higher than HLA-B*38:68Q homozygous cells. The HLA-B*38:68Q expression was further confirmed using anti-B38 polyclonal antibody. Similarly, the expression of the HLA-B*38:01:01:01 homozygous cells was 1.5 fold higher than that of HLA-B*38:68Q/B*38:01:01:01 heterozygous cells, and the HLA-B*38:68Q/B*38:01:01:01 heterozygous cells was over 1.6 fold higher than that of HLA-B*38:68Q homozygous cells. The treatment of HLA-B*38:68Q homozygous cells with IFN-Îł significantly increased its expression. In conclusion, we demonstrate that HLA-B*38:68Q is a low-expressing HLA allele. The CRISPR/Cas9 technology is a useful tool to induce precise gene editing in HLA genes to enable the characterization of HLA gene variants on expression and function
Perturbation Theory of Schr\"odinger Operators in Infinitely Many Coupling Parameters
In this paper we study the behavior of Hamilton operators and their spectra
which depend on infinitely many coupling parameters or, more generally,
parameters taking values in some Banach space. One of the physical models which
motivate this framework is a quantum particle moving in a more or less
disordered medium. One may however also envisage other scenarios where
operators are allowed to depend on interaction terms in a manner we are going
to discuss below. The central idea is to vary the occurring infinitely many
perturbing potentials independently. As a side aspect this then leads naturally
to the analysis of a couple of interesting questions of a more or less purely
mathematical flavor which belong to the field of infinite dimensional
holomorphy or holomorphy in Banach spaces. In this general setting we study in
particular the stability of selfadjointness of the operators under discussion
and the analyticity of eigenvalues under the condition that the perturbing
potentials belong to certain classes.Comment: 25 pages, Late
Constraining supersymmetry from the satellite experiments
In this paper we study the detectability of -rays from dark matter
annihilation in the subhalos of the Milky Way by the satellite-based
experiments, EGRET and GLAST. We work in the frame of supersymmetric extension
of the standard model and assume the lightest neutralino being the dark matter
particles. Based on the N-body simulation of the evolution of dark matter
subhalos we first calculate the average intensity distribution of this new
class of -ray sources by neutralino annihilation. It is possible to
detect these -ray sources by EGRET and GLAST. Conversely, if these
sources are not detected the nature of the dark matter particls will be
constrained by these experiments, which, however, depending on the
uncertainties of the subhalo profile.Comment: 19 pages, 5 gigures; references added, more discussions adde
Observation of small scale structure using sextupole lensing
Weak gravitational lensing seeks to determine shear by measuring induced
quadrupole (elliptical) shapes in background galaxy images. Small impact
parameter (a few kpc) gravitational lensing by foreground core masses between 2
10^{9} and 2 10^{12} M_\odot will additionally induce a sextupole shape with
the quadrupole and sextupole minima aligned. This correlation in relative
orientation of the quadrupole and sextupole provides a sensitive method to
identify images which have been slightly curved by lensing events. A general
theoretical framework for sextupole lensing is developed which includes several
low order coefficients in a general lensing map. Tools to impute map
coefficients from the galaxy images are described and applied to the north
Hubble deep field. Instrumental PSFs, camera charge diffusion, and image
composition methods are modelled in the coefficient determination process.
Estimates of Poisson counting noise for each galaxy are used to cut galaxies
with signals too small to reliably establish curvature. Curved galaxies are
found to be spatially clumped, as would be expected if the curving were due to
small impact parameter lensing by localized ensembles of dark matter haloes.
Simulations provide an estimate of the total required lensing mass and the
acceptable mass range of the constituent haloes. The overdensities and
underdensities of visible galaxies and their locations in the Hubble foreground
is found to be consistent with our observations and their interpretation as
lensing events.Comment: 40 pages, 44 figure
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