1,400 research outputs found
Experiments in dynamic control of autonomous marine vehicles using acoustic modems
Marine robots are an increasingly attractive means for observing and monitoring in the ocean, but underwater acoustic communication (“acomms”) remains a major challenge, especially for real-time control. Packet loss occurs widely, bit rates are low, and there are significant delays. We consider here strategies for feedback control with acomms links in either the sensor-controller channel, or the controller-actuator channel. On the controller-actuator side we implement sparse packetized predictive control (S-PPC), which simultaneously addresses packet-loss and the data rate limit. For the sensor-controller channel we study a modified information filter (MIF) in a Linear Quadratic Gaussian (LQG) control scheme. Field experiments were carried out with both approaches, regulating crosstrack error in a robotic kayak using acomms. Outcomes with both the S-PPC and MIF LQG confirm that good performance is achievable.United States. Office of Naval Research (Grant N00014-09-1-0700)National Science Foundation (U.S.) (Contract CNS-1212597)Finmeccanic
Role of AMPA Receptor Cycling in Synaptic Transmission and Plasticity
AbstractCompounds known to disrupt exocytosis or endocytosis were introduced into CA1 pyramidal cells while monitoring excitatory postsynaptic currents (EPSCs). Disrupting exocytosis or the interaction of GluR2 with NSF caused a gradual reduction in the AMPAR EPSC, while inhibition of endocytosis caused a gradual increase in the AMPAR EPSC. These manipulations had no effect on the NMDAR EPSC but prevented the subsequent induction of LTD. These results suggest that AMPARs, but not NMDARs, cycle into and out of the synaptic membrane at a rapid rate and that certain forms of synaptic plasticity may utilize this dynamic process
Scheduling Discovery in the 2020s
The 2020s will be the most data-rich decade of astronomy in history. As the scale and complexity of our surveys increase, the problem of scheduling becomes more critical. We must develop high-quality scheduling approaches, implement them as open-source software, and begin linking the typically separate stages of observation and data analysis
The Zwicky Transient Facility: Surveys and Scheduler
We present a novel algorithm for scheduling the observations of time-domain
imaging surveys. Our Integer Linear Programming approach optimizes an observing
plan for an entire night by assigning targets to temporal blocks, enabling
strict control of the number of exposures obtained per field and minimizing
filter changes. A subsequent optimization step minimizes slew times between
each observation. Our optimization metric self-consistently weights
contributions from time-varying airmass, seeing, and sky brightness to maximize
the transient discovery rate. We describe the implementation of this algorithm
on the surveys of the Zwicky Transient Facility and present its on-sky
performance.Comment: Published in PASP Focus Issue on the Zwicky Transient Facility
(https://dx.doi.org/10.1088/1538-3873/ab0c2a). 13 Pages, 11 Figure
Hnrnph1 Is A Quantitative Trait Gene for Methamphetamine Sensitivity.
Psychostimulant addiction is a heritable substance use disorder; however its genetic basis is almost entirely unknown. Quantitative trait locus (QTL) mapping in mice offers a complementary approach to human genome-wide association studies and can facilitate environment control, statistical power, novel gene discovery, and neurobiological mechanisms. We used interval-specific congenic mouse lines carrying various segments of chromosome 11 from the DBA/2J strain on an isogenic C57BL/6J background to positionally clone a 206 kb QTL (50,185,512-50,391,845 bp) that was causally associated with a reduction in the locomotor stimulant response to methamphetamine (2 mg/kg, i.p.; DBA/2J < C57BL/6J)-a non-contingent, drug-induced behavior that is associated with stimulation of the dopaminergic reward circuitry. This chromosomal region contained only two protein coding genes-heterogeneous nuclear ribonucleoprotein, H1 (Hnrnph1) and RUN and FYVE domain-containing 1 (Rufy1). Transcriptome analysis via mRNA sequencing in the striatum implicated a neurobiological mechanism involving a reduction in mesolimbic innervation and striatal neurotransmission. For instance, Nr4a2 (nuclear receptor subfamily 4, group A, member 2), a transcription factor crucial for midbrain dopaminergic neuron development, exhibited a 2.1-fold decrease in expression (DBA/2J < C57BL/6J; p 4.2 x 10-15). Transcription activator-like effector nucleases (TALENs)-mediated introduction of frameshift deletions in the first coding exon of Hnrnph1, but not Rufy1, recapitulated the reduced methamphetamine behavioral response, thus identifying Hnrnph1 as a quantitative trait gene for methamphetamine sensitivity. These results define a novel contribution of Hnrnph1 to neurobehavioral dysfunction associated with dopaminergic neurotransmission. These findings could have implications for understanding the genetic basis of methamphetamine addiction in humans and the development of novel therapeutics for prevention and treatment of substance abuse and possibly other psychiatric disorders
Dipole-phonon quantum logic with alkaline-earth monoxide and monosulfide cations
Dipole-phonon quantum logic (DPQL) leverages the interaction between polar
molecular ions and the motional modes of a trapped-ion Coulomb crystal to
provide a potentially scalable route to quantum information science. Here, we
study a class of candidate molecular ions for DPQL, the cationic alkaline-earth
monoxides and monosulfides, which possess suitable structure for DPQL and can
be produced in existing atomic ion experiments with little additional
complexity. We present calculations of DPQL operations for one of these
molecules, CaO, and discuss progress towards experimental realization. We
also further develop the theory of DPQL to include state preparation and
measurement and entanglement of multiple molecular ions.Comment: 10 pages, 6 figure
Non-perturbative embedding of local defects in crystalline materials
We present a new variational model for computing the electronic first-order
density matrix of a crystalline material in presence of a local defect. A
natural way to obtain variational discretizations of this model is to expand
the difference Q between the density matrix of the defective crystal and the
density matrix of the perfect crystal, in a basis of precomputed maximally
localized Wannier functions of the reference perfect crystal. This approach can
be used within any semi-empirical or Density Functional Theory framework.Comment: 13 pages, 4 figure
Zwicky Transient Facility constraints on the optical emission from the nearby repeating FRB 180916.J0158+65
The discovery rate of fast radio bursts (FRBs) is increasing dramatically
thanks to new radio facilities. Meanwhile, wide-field instruments such as the
47 deg Zwicky Transient Facility (ZTF) survey the optical sky to study
transient and variable sources. We present serendipitous ZTF observations of
the CHIME repeating source FRB 180916.J0158+65, that was localized to a spiral
galaxy 149 Mpc away and is the first FRB suggesting periodic modulation in its
activity. While 147 ZTF exposures corresponded to expected high-activity
periods of this FRB, no single ZTF exposure was at the same time as a CHIME
detection. No optical source was found at the FRB location in 683
ZTF exposures, totalling 5.69 hours of integration time. We combined ZTF upper
limits and expected repetitions from FRB 180916.J0158+65 in a statistical
framework using a Weibull distribution, agnostic of periodic modulation priors.
The analysis yielded a constraint on the ratio between the optical and radio
fluences of , corresponding to an optical energy erg for a fiducial 10 Jy ms FRB (90%
confidence). A deeper (but less statistically robust) constraint of can be placed assuming a rate of Jy ms)= hr and
FRB occurring during exposures taken in high-activity windows. The
constraint can be improved with shorter per-image exposures and longer
integration time, or observing FRBs at higher Galactic latitudes. This work
demonstrated how current surveys can statistically constrain multi-wavelength
counterparts to FRBs even without deliberately scheduled simultaneous radio
observation.Comment: Accepted for publication in ApJL, 9 pages, 4 figures, 1 tabl
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