Information Management System for the California State Water Resources Control Board (SWRCB)

A study was made to establish the requirements for an integrated state-wide information management system for water quality control and water quality rights for the State of California. The data sources and end requirements were analyzed for the data collected and used by the numerous agencies, both State and Federal, as well as the nine Regional Boards under the jurisdiction of the State Board. The report details the data interfaces and outlines the system design. A program plan and statement of work for implementation of the project is included

Biological Monitoring of the Capsule Mechanical Training Model During Assembly in the Sterilization Assembly Development Laboratory

Microbial burden sterilization assembly procedure development using rigorous monitoring progra

Effect of environment on biological burden during spacecraft assembly

Determining effects of environment on accumulation of biological burden on spacecraft during assembl

Wind Field and Trajectory Models for Tornado-Propelled Objects

A mathematical model to predict the trajectory of tornado born objects postulated to be in the vicinity of nuclear power plants is developed. An improved tornado wind field model satisfied the no slip ground boundary condition of fluid mechanics and includes the functional dependence of eddy viscosity with altitude. Subscale wind tunnel data are obtained for all of the missiles currently specified for nuclear plant design. Confirmatory full-scale data are obtained for a 12 inch pipe and automobile. The original six degree of freedom trajectory model is modified to include the improved wind field and increased capability as to body shapes and inertial characteristics that can be handled. The improved trajectory model is used to calculate maximum credible speeds, which for all of the heavy missiles are considerably less than those currently specified for design. Equivalent coefficients for use in three degree of freedom models are developed and the sensitivity of range and speed to various trajectory parameters for the 12 inch diameter pipe are examined

The pharmacological regulation of cellular mitophagy

Small molecules are pharmacological tools of considerable value for dissecting complex biological processes and identifying potential therapeutic interventions. Recently, the cellular quality-control process of mitophagy has attracted considerable research interest; however, the limited availability of suitable chemical probes has restricted our understanding of the molecular mechanisms involved. Current approaches to initiate mitophagy include acute dissipation of the mitochondrial membrane potential (ΔΨm) by mitochondrial uncouplers (for example, FCCP/CCCP) and the use of antimycin A and oligomycin to impair respiration. Both approaches impair mitochondrial homeostasis and therefore limit the scope for dissection of subtle, bioenergy-related regulatory phenomena. Recently, novel mitophagy activators acting independently of the respiration collapse have been reported, offering new opportunities to understand the process and potential for therapeutic exploitation. We have summarized the current status of mitophagy modulators and analyzed the available chemical tools, commenting on their advantages, limitations and current applications

Caltech/JPL Conference on Image Processing Technology, Data Sources and Software for Commercial and Scientific Applications

Recent advances in image processing and new applications are presented to the user community to stimulate the development and transfer of this technology to industrial and commercial applications. The Proceedings contains 37 papers and abstracts, including many illustrations (some in color) and provides a single reference source for the user community regarding the ordering and obtaining of NASA-developed image-processing software and science data