156 research outputs found
Ariel - Volume 7 Number 1
Editors
Mark Dembert
Frank Chervanek
John Lammie
Jim Burke
Nancy Redfern
Business
Alf Levy
Photographer
Larry Glazerman
Staff
Hal Faust
Curt Cummings
Bob Levin
tOO mUCH (University Medical College Hospital - London
Pharmacological validation of individual animal locomotion, temperature and behavioural analysis in group-housed rats using a novel automated home cage analysis system: A comparison with the modified Irwin test
Edward Thompson's Ethics and Activism 1956β1963: Reflections on the Political Formation of The Making of the English Working Class
As well as a work of history, E. P. Thompson's The Making of the English Class (London: Gollancz, 1963) was written as a strategic intervention in wider political debates of the late 1950s about working class consciousness, identity, agency and organisation, and as a sustained expression and application of βsocialist humanismβ to historical subjects. This essay situates the book within these debates, moving between The Making and Thompson's writings within the New Left, to show how the characteristic themes of his workβmoral choice and agency, the complexities of working-class consciousness and culture, the role of intellectuals and of an βorganised minorityββwere developed through both. This provides us with a richer context for understanding both the moral sensibility that animates the book and key elements of its historiographical standpoint
Automated recording of home cage activity and temperature of individual rats housed in social groups: The Rodent Big Brother project
Measuring the activity and temperature of rats is commonly required in biomedical research. Conventional approaches necessitate single housing, which affects their behavior and wellbeing. We have used a subcutaneous radiofrequency identification (RFID) transponder to measure ambulatory activity and temperature of individual rats when group-housed in conventional, rack-mounted home cages. The transponder location and temperature is detected by a matrix of antennae in a baseplate under the cage. An infrared high-definition camera acquires side-view video of the cage and also enables automated detection of vertical activity. Validation studies showed that baseplate-derived ambulatory activity correlated well with manual tracking and with side-view whole-cage video pixel movement. This technology enables individual behavioral and temperature data to be acquired continuously from group-housed rats in their familiar, home cage environment. We demonstrate its ability to reliably detect naturally occurring behavioral effects, extending beyond the capabilities of routine observational tests and conventional monitoring equipment. It has numerous potential applications including safety pharmacology, toxicology, circadian biology, disease models and drug discovery
Medication Persistence Rates and Factors Associated with Persistence in Patients Following Stroke: A Cohort Study
This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens
Reversing the Outcome of Synapse Elimination at Developing Neuromuscular Junctions In Vivo: Evidence for Synaptic Competition and Its Mechanism
Competition between neurons for the same synaptic sites at the developing neuromuscular junction drives synaptic rearrangements
Development and testing of innovative patient resources for the management of coronary heart disease (CHD): a descriptive study
BACKGROUND: Although heart disease is a major cause of morbidity and mortality the majority of patients do not access existing rehabilitation programs and patient resources are not designed to facilitate patient choice and decision-making. The objective of this study was to develop and test a series of risk factor modules and corresponding patient information leaflets for secondary prevention of CHD. METHODS: In phase one, a series of risk factor modules and management options were developed following analysis of literature and interviews with health professionals. In phase two, module information leaflets were developed using published guidelines and interviews of people with CHD. In phase three, the leaflets were tested for quality (DISCERN), readability (Flesch) and suitability (SAM) and were compared to the existing cardiac rehabilitation (CR) information leaflet. Finally, the patients assessed the leaflets for content and relevance. RESULTS: Four key risk factors identified were cholesterol, blood pressure, smoking and physical inactivity. Choice management options were selected for each risk factor and included medical consultation, intensive health professional led program, home program and self direction. Patient information needs were then identified and leaflets were developed. DISCERN quality scores were high for cholesterol (62/80), blood pressure (59/80), smoking (62/80) and physical activity (62/80), all scoring 4/5 for overall rating. The mean Flesch readability score was 75, representing "fairly easy to read", all leaflets scored in the superior category for suitability and were reported to be easy to understand, useful and motivating by persons with CHD risk factors. The developed leaflets scored higher on each assessment than the existing CR leaflets. CONCLUSION: Using a progressive three phase approach, a series of risk factor modules and information leaflets were successfully developed and tested. The leaflets will contribute to shared-decision making and empowerment for persons with CHD
Selective innervation of neonatal fast and slow muscle fibres before net loss of synaptic terminals in the mouse soleus muscle
Selective innervation of neonatal fast and slow muscle fibres before net loss of synaptic terminals in the mouse soleus muscle
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