New Spectroscopic Observations of the Post-AGB Star V354Lac=IRAS22272+5435

The strongest absorption features with the lower-level excitation potentials $\chi_{\rm low}<1$ eV are found to be split in the high-resolution optical spectra of the post-AGB star V354 Lac taken in 2007--2008. Main parameters, T$_{eff}$=5650 K, $\log g$=0.2, $\xi_t$=5.0 km/s, and the abundances of 22 chemical elements in the star's atmosphere are found. The overabundance of the $s$-process chemical elements (Ba, La, Ce, Nd) in the star's atmosphere is partly due to the splitting of strong lines of the ions of these metals. The peculiarities of the spectrum in the wavelength interval containing the LiI $\lambda$ 6707 \AA{} line can be naturally explained only by taking the overabundances of the CeII and SmII heavy-metal ions into account. The best agreement with the synthetic spectrum is achieved assuming $\epsilon$(LiI)=2.0, $\epsilon$(CeII)=3.2, and $\epsilon$(SmII)=2.7. The velocity field both in the atmosphere and in the circumstellar envelope of V354 Lac remained stationary throughout the last 15 years of our observations.Comment: 16 pages, 6 figures, 2 table

A Model for the Development of the Rhizobial and Arbuscular Mycorrhizal Symbioses in Legumes and Its Use to Understand the Roles of Ethylene in the Establishment of these two Symbioses

We propose a model depicting the development of nodulation and arbuscular mycorrhizae. Both processes are dissected into many steps, using Pisum sativum L. nodulation mutants as a guideline. For nodulation, we distinguish two main developmental programs, one epidermal and one cortical. Whereas Nod factors alone affect the cortical program, bacteria are required to trigger the epidermal events. We propose that the two programs of the rhizobial symbiosis evolved separately and that, over time, they came to function together. The distinction between these two programs does not exist for arbuscular mycorrhizae development despite events occurring in both root tissues. Mutations that affect both symbioses are restricted to the epidermal program. We propose here sites of action and potential roles for ethylene during the formation of the two symbioses with a specific hypothesis for nodule organogenesis. Assuming the epidermis does not make ethylene, the microsymbionts probably first encounter a regulatory level of ethylene at the epidermis–outermost cortical cell layer interface. Depending on the hormone concentrations there, infection will either progress or be blocked. In the former case, ethylene affects the cortex cytoskeleton, allowing reorganization that facilitates infection; in the latter case, ethylene acts on several enzymes that interfere with infection thread growth, causing it to abort. Throughout this review, the difficulty of generalizing the roles of ethylene is emphasized and numerous examples are given to demonstrate the diversity that exists in plants

Detection of the spectral binary (SB2) nature of BD-6^o1178

BD-6^o1178 identified with the infrared source IRAS05238-0626 is shown for the first time to be a spectroscopic binary (SB2) by analyzing the high-resolution spectra taken with the NES echelle spectrograph of the 6-m telescope. The components of the binary have close spectral types and luminosity classes: F5IV-III and F3V. The heliocentric radial velocities are measured for both components at four observing moments in 2004-2005. Both stars have close rotation velocities, which are equal to 24 and 19km/s. We do not confirm the classification of BD-6^o1178 as a supergiant in the transition stage of becoming a planetary nebula. BD-6^o1178 probably is a young pre-MS stars. It is possibly a member of the 1c subgroup of the OriOB1 association.Comment: 13 pages, 1 table, 4 figure

Global Retinoblastoma Presentation and Analysis by National Income Level

Importance: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. Objectives: To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis. Design, Setting, and Participants: A total of 278 retinoblastoma treatment centers were recruited from June 2017 through December 2018 to participate in a cross-sectional analysis of treatment-naive patients with retinoblastoma who were diagnosed in 2017. Main Outcomes and Measures: Age at presentation, proportion of familial history of retinoblastoma, and tumor stage and metastasis. Results: The cohort included 4351 new patients from 153 countries; the median age at diagnosis was 30.5 (interquartile range, 18.3-45.9) months, and 1976 patients (45.4) were female. Most patients (n = 3685 84.7%) were from low-and middle-income countries (LMICs). Globally, the most common indication for referral was leukocoria (n = 2638 62.8%), followed by strabismus (n = 429 10.2%) and proptosis (n = 309 7.4%). Patients from high-income countries (HICs) were diagnosed at a median age of 14.1 months, with 656 of 666 (98.5%) patients having intraocular retinoblastoma and 2 (0.3%) having metastasis. Patients from low-income countries were diagnosed at a median age of 30.5 months, with 256 of 521 (49.1%) having extraocular retinoblastoma and 94 of 498 (18.9%) having metastasis. Lower national income level was associated with older presentation age, higher proportion of locally advanced disease and distant metastasis, and smaller proportion of familial history of retinoblastoma. Advanced disease at diagnosis was more common in LMICs even after adjusting for age (odds ratio for low-income countries vs upper-middle-income countries and HICs, 17.92 95% CI, 12.94-24.80, and for lower-middle-income countries vs upper-middle-income countries and HICs, 5.74 95% CI, 4.30-7.68). Conclusions and Relevance: This study is estimated to have included more than half of all new retinoblastoma cases worldwide in 2017. Children from LMICs, where the main global retinoblastoma burden lies, presented at an older age with more advanced disease and demonstrated a smaller proportion of familial history of retinoblastoma, likely because many do not reach a childbearing age. Given that retinoblastoma is curable, these data are concerning and mandate intervention at national and international levels. Further studies are needed to investigate factors, other than age at presentation, that may be associated with advanced disease in LMICs. © 2020 American Medical Association. All rights reserved