van der Woude syndrome- a syndromic form of orofacial clefting

van der Woude Syndrome is the most common form of syndromic orofacial clefting, accounting for 2% of all cases, and has the phenotype that most closely resembles the more common non-syndromic forms. The syndrome has an autosomal dominant hereditary pattern with variable expressivity and a high degree of penetrance with cardinal clinical features of lip pits with a cleft lip, cleft palate, or both. This case report describes van der Woude syndrome in a 19 year old male patient with a specifi c reference to the various aspects of this condition, as clinical appearance, etiological factors (genetic aspects), differential diagnosis, investigative procedures and management

First mineralogical maps of 4 Vesta

Before Dawn arrived at 4 Vesta only very low spatial resolution (~50 km) albedo and color maps were available from HST data. Also ground-based color and spectroscopic data were utilized as a first attempt to map Vesta’s mineralogical diversity [1-4]. The VIR spectrometer [5] onboard Dawn has ac-quired hyperspectral data while the FC camera [6] ob-tained multi-color data of the Vestan surface at very high spatial resolutions, allowing us to map complex geologic, morphologic units and features. We here re-port about the results obtained from a preliminary global mineralogical map of Vesta, based on data from the Survey orbit. This map is part of an iterative map-ping effort; the map is refined with each improvement in resolution

Mapping the mineralogical composition of the Pinaria region (Av-11) of Vesta

We present the mineralogical map of a quadrant of the southern hemisphere of Vesta spanning 0-90 degrees longitude, and -21 to -66 degrees latitude; a region named Pinaria. The region, named after the Roman vestal virgin (c. 600 B.C.), includes an approximately 37km diameter crater, also named Pinaria. Several additional large craters are in this region as is the western most region of the rim of Rhea Silvia, named Matronalia Rupes. Mineralogical maps are based on data acquired by the Visible and Infrared Mapping Spectrometer (VIR-MS) and the Framing Camera (FC) on the Dawn spacecraft that has been orbiting Vesta since July 2011. VIR-MS is sensitive to wavelengths from 0.25um to 5.1um with a spatial resolution that depends upon the mission phase: nominally from 2.5 up to 0.8 km/pixel during the approach, 0.8 km/pixel during survey, 0.2 km/pixel during the high altitude orbit (HAMO) and about 0.05 km/pixel during the low altitude orbit (LAMO). This spatial resolution does not include the effects of the spacecraft's nor Vesta's motion. FC data from Survey orbit with a spatial resolution of about 250 m/pixel have been mapped using filter band parameters selected to enhance the anticipated mineralogy of Vesta. Global color maps of Vesta's surface using these color differences and ratios are generated. VIR data show that Vesta's surface is dominated by pyroxenes, with no evidence for the presence of other minerals observed at the scale of the survey measurements. The spectral parameters of the two major pyroxene absorption bands including band centers, depths and band areas and their variation within the Pinaria region, suggest mineralogical variation representing different compositional and/or textural terrains. Matronalia Rupes has band parameters suggesting different composition or grain size possibly resulting from down slope motion of regolith revealing different material beneath. The authors gratefully acknowledge the support of the Dawn Instrument, Operations, and Science Teams. This work is supported by an Italian Space Agency (ASI) grant, the DLR, MPI and by NASA through the Dawn project and the Dawn at Vesta Participating Scientist grant

The INtegrated CAtchment model of phosphorus dynamics (INCA-P): description and demonstration of new model structure and equations

INCA-P is a dynamic, catchment-scale phosphorus model which has been widely applied during the last decade. Since its original release in 2002, the model structure and equations have been significantly altered during several development phases. Here, we provide the first full model description since 2002 and then test the latest version of the model (v1.4.4) in a small rural catchment in northeast Scotland. The particulate phosphorus simulation was much improved compared to previous model versions, whilst the latest sorption equations allowed us to explore the potential time lags between reductions in terrestrial inputs and improvements in surface water quality, an issue of key policy relevance. The model is particularly suitable for use as a research tool, but should only be used to inform policy and land management in data-rich areas, where parameters and processes can be well-constrained. More long-term data is needed to parameterise dynamic models and test their predictions

Capturing wheat phenotypes at the genome level

Recent technological advances in next-generation sequencing (NGS) technologies have dramatically reduced the cost of DNA sequencing, allowing species with large and complex genomes to be sequenced. Although bread wheat (Triticum aestivum L.) is one of the world’s most important food crops, efficient exploitation of molecular marker-assisted breeding approaches has lagged behind that achieved in other crop species, due to its large polyploid genome. However, an international public–private effort spanning 9 years reported over 65% draft genome of bread wheat in 2014, and finally, after more than a decade culminated in the release of a gold-standard, fully annotated reference wheat-genome assembly in 2018. Shortly thereafter, in 2020, the genome of assemblies of additional 15 global wheat accessions was released. As a result, wheat has now entered into the pan-genomic era, where basic resources can be efficiently exploited. Wheat genotyping with a few hundred markers has been replaced by genotyping arrays, capable of characterizing hundreds of wheat lines, using thousands of markers, providing fast, relatively inexpensive, and reliable data for exploitation in wheat breeding. These advances have opened up new opportunities for marker-assisted selection (MAS) and genomic selection (GS) in wheat. Herein, we review the advances and perspectives in wheat genetics and genomics, with a focus on key traits, including grain yield, yield-related traits, end-use quality, and resistance to biotic and abiotic stresses. We also focus on reported candidate genes cloned and linked to traits of interest. Furthermore, we report on the improvement in the aforementioned quantitative traits, through the use of (i) clustered regularly interspaced short-palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9)-mediated gene-editing and (ii) positional cloning methods, and of genomic selection. Finally, we examine the utilization of genomics for the next-generation wheat breeding, providing a practical example of using in silico bioinformatics tools that are based on the wheat reference-genome sequence

Psychosocial Treatment of Children in Foster Care: A Review

A substantial number of children in foster care exhibit psychiatric difficulties. Recent epidemiologi-cal and historical trends in foster care, clinical findings about the adjustment of children in foster care, and adult outcomes are reviewed, followed by a description of current approaches to treatment and extant empirical support. Available interventions for these children can be categorized as either symptom-focused or systemic, with empirical support for specific methods ranging from scant to substantial. Even with treatment, behavioral and emotional problems often persist into adulthood, resulting in poor functional outcomes. We suggest that self-regulation may be an important mediat-ing factor in the appearance of emotional and behavioral disturbance in these children