A Proposed Method for Monitoring U.S. Population Health: Linking Symptoms, Impairments, and Health Ratings

We propose a method of quantifying non-fatal health on a 0-1 QALY scale that details the impact of specific symptoms and impairments and is not based on ratings of counterfactual scenarios. Measures of general health status are regressed on health impairments and symptoms in different domains, using ordered probit and ordinary least squares regression. This yields estimates of their effects analogous to disutility weights, and accounts for complex non-additive relationships. Health measures used include self-rated health status on a 5-point scale, EuroQol 5D (EQ-5D) scores, and ratings of current health using a 0-100 rating scale and a time-tradeoff. Data are from the nationally representative Medical Expenditure Panel Survey (MEPS) year 2002 (N=34,615), with validation in an independent sample from MEPS 2000 (N=21,067) and among 1420 adults age 45-89 in the Beaver Dam Health Outcomes Study. Decrement weights for symptoms and impairments are used to derive estimates of overall health-related quality of life, laying the groundwork for a detailed national summary measure of health. To purchase a copy of the earlier version of this paper, please contact the Working Papers department directly at (617) 588 1405.

The Complexity of Disrupting the Struggling Reader Label: The Potential for Cross-Pollinating Disability Studies and Dynamic Models of Comprehension in Literacy Teacher Education

There have been numerous recent calls in literacy research and teacher education to disrupt the \u27struggling reader\u27 label, but a dearth of empirical studies on the topic. This qualitative analysis explores the complex issues preservice teachers (PSTs) faced as they examined young readers\u27 sense-making through a reading assessment assignment. Our research question asked: How do PSTs challenge and/or reinforce the \u27struggling reader\u27 label as they examine young readers\u27 sense-making? Using a conceptual lens that cross-pollinates dynamic models of reading comprehension with Disability Studies in Education, we look across three cases to identify ways PSTs challenged and reinforced the \u27struggling reader\u27 label as they examined intermediate-grade readers\u27 interactions with texts. Ultimately, we argue that embracing a dynamic model of comprehension--on its own--is an insufficient focus in literacy teacher education in order to disrupt harmful labeling practices in schools

Safe use of symbols in handover documentation for medical teams

Concern has been reported about the safe use of medical abbreviations in documents such as handover sheets and medical notes, especially when information is being communicated between staff of different specialties (BBC 2008, Sheppard et al. 2008). This article describes a study to investigate whether the use of symbols in handover documentation that is shared within and between multidisciplinary teams (MDTs) has similar safety implications. We asked 19 healthcare professionals from a range of specialties to identify 45 different combinations of 38 individual symbols. The symbols and combinations of symbols were extracted from 102 handover sheets taken from 6 different healthcare contexts in 4 London hospitals. Three symbols proposed in Microsoft's Common User Interface guidelines for alert symbols were also included. Results reveal that while some symbols are well understood, many others are either ambiguous or unknown. These results have implications for the safe use of symbols in medical documents, including paper and electronic handover documents and Electronic Patient Records (EPRs), especially where teams comprise individuals from different professional backgrounds, i.e. MDTs. We offer initial suggestions for standardisation and further research

A simple procedure for the production of large ferromagnetic cobalt nanoparticles

© The Royal Society of Chemistry 2016. Epsilon cobalt (ε-Co) nanoparticles in a number of octahedral morphologies have been synthesised. The particles are polycrystalline, with sizes in the order of 30 nm. Magnetic studies reveal the particles are ferromagnetic, with a room temperature saturation magnetisation of 131 emu g -1 . Unlike other large cubic ε-Co syntheses, we have not added an additional co-surfactant. Instead, we have modified the heating regime and reaction agitation. This alternative method highlights the complex chemistry associated with the formation of cobalt nanoparticles by thermal decomposition

Formation of sinuous ridges by inversion of river-channel belts in Utah, USA, with implications for Mars

Sinuous ridges are important landforms on the surface of Mars that show promise for quantifying ancient martian surface hydrology. Morphological similarity of these ridges to river channels in planform led to a hypothesis that ridges are topographically inverted river channels, or “inverted channels”, formed due to an erosion-resistant channel-filling material that preserved a snapshot of the channel geometry in inverted relief due to differential erosion. An alternative deposit-inversion hypothesis proposes that ridges represent exhumed river-channel belts, with geometries that reflect the lateral migration and vertical aggradation of rivers over significant geologic time, rather than the original channel geometry. To investigate these hypotheses we studied sinuous ridges within the Cretaceous Cedar Mountain Formation near Green River, Utah, USA. Ridges in Utah extend for hundreds of meters, are up to 120 m wide, and stand up to 39 m above the surrounding plain. Ridges are capped by sandstone bodies 3–10 m thick that contain dune- and bar-scale inclined stratification, which we interpret as eroded remnants of channel belts that record the migration and aggradation of single-thread, sand-bedded rivers, rather than channel fills that can preserve the original channel geometry. Caprocks overlie mudstones and thinner sandstone beds that are interpreted as floodplain deposits, and in cases additional channel-belt sandstones are present lower in the ridge stratigraphy. Apparent networks from branching ridges typically represent discrete sandstone bodies that cross at different stratigraphic levels rather than a coeval river network. Ridge-forming sandstone bodies also have been narrowed during exhumation by cliff retreat and bisected by fluvial erosion. Using a large compilation of channel-belt geometries on Earth and our measurements of ridges in Utah, we propose that caprock thickness is the most reliable indicator of paleo-channel geometry, and can be used to reconstruct river depth and discharge. In contrast, channel lateral migration and caprock erosion during exhumation make ridge breadth an uncertain proxy for channel width. An example in Aeolis Dorsa, Mars, illustrates that river discharge estimates based solely on caprock width may differ significantly from estimates based on caprock thickness. Overall, our study suggests that sinuous ridges are not inverted channel fills, but rather reflect exhumation of a thick stratigraphic package of stacked channel belts and overbank deposits formed from depositional rivers over significant geologic time

Ancillary health effects of climate mitigation scenarios as drivers of policy uptake: a review of air quality, transportation and diet co-benefits modeling studies

Background: Significant mitigation efforts beyond the Nationally Determined Commitments (NDCs) coming out of the 2015 Paris Climate Agreement are required to avoid warming of 2 °C above pre-industrial temperatures. Health co-benefits represent selected near term, positive consequences of climate policies that can offset mitigation costs in the short term before the beneficial impacts of those policies on the magnitude of climate change are evident. The diversity of approaches to modeling mitigation options and their health effects inhibits meta-analyses and syntheses of results useful in policy-making. Methods/Design: We evaluated the range of methods and choices in modeling health co-benefits of climate mitigation to identify opportunities for increased consistency and collaboration that could better inform policy-making. We reviewed studies quantifying the health co-benefits of climate change mitigation related to air quality, transportation, and diet published since the 2009 Lancet Commission 'Managing the health effects of climate change' through January 2017. We documented approaches, methods, scenarios, health-related exposures, and health outcomes. Results/Synthesis: Forty-two studies met the inclusion criteria. Air quality, transportation, and diet scenarios ranged from specific policy proposals to hypothetical scenarios, and from global recommendations to stakeholder-informed local guidance. Geographic and temporal scope as well as validity of scenarios determined policy relevance. More recent studies tended to use more sophisticated methods to address complexity in the relevant policy system. Discussion: Most studies indicated significant, nearer term, local ancillary health benefits providing impetus for policy uptake and net cost savings. However, studies were more suited to describing the interaction of climate policy and health and the magnitude of potential outcomes than to providing specific accurate estimates of health co-benefits. Modeling the health co-benefits of climate policy provides policy-relevant information when the scenarios are reasonable, relevant, and thorough, and the model adequately addresses complexity. Greater consistency in selected modeling choices across the health co-benefits of climate mitigation research would facilitate evaluation of mitigation options particularly as they apply to the NDCs and promote policy uptake

Prostanoid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Prostanoid receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Prostanoid Receptors [644]) are activated by the endogenous ligands prostaglandins PGD2, PGE1, PGE2 , PGF2α, PGH2, prostacyclin [PGI2] and thromboxane A2. Measurement of the potency of PGI2 and thromboxane A2 is hampered by their instability in physiological salt solution; they are often replaced by cicaprost and U46619, respectively, in receptor characterization studies

Prostanoid receptors (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database

Prostanoid receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Prostanoid Receptors [661]) are activated by the endogenous ligands prostaglandins PGD2, PGE1, PGE2 , PGF2α, PGH2, prostacyclin [PGI2] and thromboxane A2. Differences and similarities between human and rodent prostanoid receptor orthologues, and their specific roles in pathophysiologic conditions are reviewed in [423]. Measurement of the potency of PGI2 and thromboxane A2 is hampered by their instability in physiological salt solution; they are often replaced by cicaprost and U46619, respectively, in receptor characterization studies

Prostanoid receptors (version 2019.5) in the IUPHAR/BPS Guide to Pharmacology Database

Prostanoid receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Prostanoid Receptors [659]) are activated by the endogenous ligands prostaglandins PGD2, PGE1, PGE2 , PGF2α, PGH2, prostacyclin [PGI2] and thromboxane A2. Measurement of the potency of PGI2 and thromboxane A2 is hampered by their instability in physiological salt solution; they are often replaced by cicaprost and U46619, respectively, in receptor characterization studies

Formation of sinuous ridges by inversion of river-channel belts in Utah, USA, with implications for Mars

Sinuous ridges are important landforms on the surface of Mars that show promise for quantifying ancient martian surface hydrology. Morphological similarity of these ridges to river channels in planform led to a hypothesis that ridges are topographically inverted river channels, or “inverted channels”, formed due to an erosion-resistant channel-filling material that preserved a snapshot of the channel geometry in inverted relief due to differential erosion. An alternative deposit-inversion hypothesis proposes that ridges represent exhumed river-channel belts, with geometries that reflect the lateral migration and vertical aggradation of rivers over significant geologic time, rather than the original channel geometry. To investigate these hypotheses we studied sinuous ridges within the Cretaceous Cedar Mountain Formation near Green River, Utah, USA. Ridges in Utah extend for hundreds of meters, are up to 120 m wide, and stand up to 39 m above the surrounding plain. Ridges are capped by sandstone bodies 3–10 m thick that contain dune- and bar-scale inclined stratification, which we interpret as eroded remnants of channel belts that record the migration and aggradation of single-thread, sand-bedded rivers, rather than channel fills that can preserve the original channel geometry. Caprocks overlie mudstones and thinner sandstone beds that are interpreted as floodplain deposits, and in cases additional channel-belt sandstones are present lower in the ridge stratigraphy. Apparent networks from branching ridges typically represent discrete sandstone bodies that cross at different stratigraphic levels rather than a coeval river network. Ridge-forming sandstone bodies also have been narrowed during exhumation by cliff retreat and bisected by fluvial erosion. Using a large compilation of channel-belt geometries on Earth and our measurements of ridges in Utah, we propose that caprock thickness is the most reliable indicator of paleo-channel geometry, and can be used to reconstruct river depth and discharge. In contrast, channel lateral migration and caprock erosion during exhumation make ridge breadth an uncertain proxy for channel width. An example in Aeolis Dorsa, Mars, illustrates that river discharge estimates based solely on caprock width may differ significantly from estimates based on caprock thickness. Overall, our study suggests that sinuous ridges are not inverted channel fills, but rather reflect exhumation of a thick stratigraphic package of stacked channel belts and overbank deposits formed from depositional rivers over significant geologic time