Motivations for Lifelong Learning in the Life of Mrs. Hendrika Schuster.

As we enter the 21st century our population of elderly citizens is growing at a rate never seen before in our history. With the baby boomers retiring, society is realizing the vast potential of untapped resources. These individuals are also seeking opportunities to remain as active and engaged members of their communities. The purpose of this study was to examine the motivations for lifelong learning in the life of Hendrika Henny Schuster, an 81-year-old resident of Abingdon, Virginia. Her life story is presented in a narrative form and in a thematically organized chronological format. Interviews were conducted and recorded. These tapes were transcribed and analyzed to determine themes. Additional information was collected from personal journals, scrapbooks, and newspaper and magazine articles and photographs. The importance of family, formal educational opportunities, the influence of others, selfdirected study, and involvement in community all emerged as motivating themes in her pursuit of lifelong learning opportunities. For Henny, the factors identified as barriers to her quest included the internal stressors of family, gender, culture, and educational opportunities. Recommendations include the need to not only provide more educational opportunities for adult learners but also ensure that such opportunities are readily accessible. It is suggested that future studies look at the roles of gender and culture in regard to the ever changing populace and the global view of our world. There is a need to continue studies such as this in which older adult learners are provided opportunities to reflect on their experiences. Insight for learners of all ages can be gained from such studies

Investigation of the DYRK1A Regulation by LZTS2-SIPA1L1 Complex

A region on chromosome 21, the Down Syndrome critical region (DSCR), is associated with major defects found in Down Syndrome, such as craniofacial malformations. DYRK1A is a gene found on chromosome 21 within the DSCR that encodes an enzyme, dual specificity tyrosine-phosphorylation-regulated kinase 1A. DYRK1A is known to phosphorylate many substrate proteins and is thought to be involved in tumor suppression, neurological development, cell cycle regulation, and aging. Recently, the Litovchick lab and others reported that DYRK1A also plays a role in the double-strand break repair of DNA, which could lead to mutations and tumorigenesis, if deregulated. The Litovchick lab is currently investigating novel interactions of DYRK1A, and their implications for cancer. One of these proteins, DCAF7, is already a well-known DYRK1A interacting partner. Another less characterized protein is LZTS2, also known as LAPSER1 or leucine-zipper tumor suppressor 2. LZTS2 is found to be deleted in many human tumors and is known to bind a signaling intermediate SIPA1L1.2 Our preliminary data show that LZTS2 may promote DYRK1A phosphorylation, thereby regulating DYRK1A kinase activity. We suspect that SIPA1L1 may be involved in this interaction and, as this complex is known to be involved in the WNT pathway that plays a role in both cancer and orofacial formation, To test this hypothesis, we started characterization of the DYRK1A-LZTS2 interaction using ectopic expressions of the full-length LZTS2 and DYRK1A as well as their fragments expressed in human T98G cells. We will further perform experiments investigating the physical binding and functional interactions between DCAF7, SIPA1L1, and the DYRK1A-LZTS2 complex.https://scholarscompass.vcu.edu/uresposters/1442/thumbnail.jp

Simplified Sewer Flow Modelling

Sewer networks are designed to collect and transport stormwater runoff. The capacity of these systems can be exceeded during extreme rainfall events, which can lead to flooding. Computational modelling is used to understand the behaviour and capacity of these networks, and to determine possible flood locations. Traditional sewer models, thatwhich can be coupled with water quality or catchment hydrological models, are typically computationally expensive,. This which limits their use for real-time modelling during an event. Conceptual models that solve less complex numerical algorithms can be used for faster modelling. However, the conceptual models developed so far have often been less accurate. In this study, two conceptual sewer simulators have been developed based upon Cellular Automata (CA) principles, which have low computation times in comparison to recognised benchmark models. CA models represent the region being simulated by a grid of cells, and simple rules are used to change the cell states. These models have been tested using three case studies (one hypothetical and two real world cases). The accuracy was determined in the case studies by performing a visual and statistical analysis of the results. The statistical analysis included measures such as the Root Mean Square Error, the Nash-Sutcliffe Efficiency, and the Index of Agreement. From this and looking at the computation times of the modelsIt it has been demonstrated that these new simulators are both fast and accurate

CAPSTONE: Recovery & Operations of a Tumbling Small Satellite in Deep Space

The Cislunar Autonomous Positioning System Technology Operations and Navigation Experiment (CAPSTONE) satellite, deployed in July 2022, experienced a thruster anomaly in September 2022 during its Ballistic Lunar Transfer (BLT) into the Earth-Moon L2 Near Rectilinear Halo Orbit (NRHO). CAPSTONE\u27s primary mission objective to achieve and maintain NRHO serves to validate the cislunar CONOPS contemplated for NASA\u27s Lunar Gateway. Terran Orbital designed and built CAPSTONE, and serves as the operator of the on-orbit spacecraft. Advanced Space owns and operates the CAPSTONE payload and its software on behalf of NASA, as well as performs mission navigation and maneuver design. This 12U+ lunar nanosatellite contains a pump-fed hydrazine propulsion system from Stellar Exploration, enabling all orbital maneuvers and momentum management for the mission. The CAPSTONE mission is funded by the NASA Space Technology Mission Directorate (STMD) through the Small Spacecraft Technology program, and by the Human Exploration and Operations Mission Directorate (HEOMD) through the Advanced Exploration Systems program. This paper will examine the timeline, innovation, and steps taken by the spacecraft team to recover the vehicle from the thruster anomaly and the resulting high-rate tumble. The high-rate tumble was induced by a valve which became stuck open at the conclusion of Trajectory Correction Maneuver 3 (TCM-3). The timeline discussion includes initial autonomous fault recovery, the evolution of the state of the vehicle, and the recovery actions taken by a small, agile engineering team. The off-nominal attitude and thermal state was determined from a limited data set, requiring the largest assets in NASA\u27s Deep Space Network (DSN) to support communications with the vehicle. Once a determination was made that the hydrazine propellant was freezing, an assessment was made on the minimum amount of heat required to thaw propellant without placing the spacecraft in a power-negative state. The integrated spacecraft team performed root cause analysis and incrementally tested the propulsion system to recommission it in the face of an anomalous thruster valve. The recommissioning approach eventually lead to the development of a new propulsive state machine and Guidance Navigation and Control (GNC) thruster controller for detumbling. After recovering 3-axis attitude control, power and thermal stability, and establishing nominal communications, significant development and testing was required to ensure the vehicle could operate in the presence of a continued thruster anomaly. This effort enabled CAPSTONE to execute future propulsive maneuvers with an open thruster valve. The resultant updates were tested on Terran Orbital\u27s Hardware-in-the-Loop (HITL) platform in partnership with Stellar Exploration. A comparison of GNC subsystem requirements will be presented pre-and post-anomaly, based on the resulting capability and restrictions of the propulsion system to meet mission objectives. Ultimately, the spacecraft was successfully recovered from body rates exceeding 120 deg/s, allowing the CAPSTONE spacecraft to continue its mission, including successful insertion into NRHO in November 2022. An examination of the lessons learned for future deep space small satellite missions is also discussed herein

Minimally Invasive Repair of Elongated Chordae Tendineae in the Mitral Valve

In the United States, about 4 million people have been estimated to suffer from severe mitral valve regurgitation [5]. Due to the high risks involved, about half of those patients are ineligible for surgery to repair the valve, because of their poor health [6]. Elongation of the chordae tendineae has been found to be one of the significant causes of regurgitation. To address this, the team has developed a device called “Chord Fastener”, which will restore proper function to the valve via shortening of the chordae tendineae [1]. Via this shortening mechanism, the device will reduce mitral valve regurgitation and will be used in a minimally invasive cardiac procedure. Over the course of two academic semesters, the design and testing of the Chord Fastener was undertaken. The resulting prototype has demonstrated good promise that with refinement, it can function as intended and meet the project requirements

Overcoming the Barriers to Successful Completion of GED Programs among Prison and Jail Inmates

This study examines the barriers faced by inmates participating in General Educational Development (GED) courses in prisons and jails, with the goal of proposing strategies for the removal of these barriers. By examining the literature surrounding prison and jail GED programs, the factors are categorized as those unique to each inmate (inmate factors), those experienced within the prison environment (environmental factors), and barriers that arise as a result of social conditions (outside factors). By examining various similar examples in the literature, solutions are discussed that have helped prison inmates overcome similar barriers

Interrupted Carbonyl‐Alkyne Metathesis

Carbonyl‐olefin metathesis and carbonyl‐alkyne metathesis represent established reactivity modes between carbonyls, alkenes, and alkynes under Lewis and Brønsted acid catalysis. Recently, an interrupted carbonyl‐olefin metathesis reaction has been reported that results in tetrahydrofluorenes via a distinct fragmentation of the reactive intermediate. We herein report the development of an analogous transformation interrupting the carbonyl‐alkyne metathesis reaction path resulting in dihydrofluorene products relying on Lewis acidic superelectrophiles as active catalytic species.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153682/1/adsc201901358.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/153682/2/adsc201901358_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/153682/3/adsc201901358-sup-0001-misc_information.pd

I Keep my Problems to Myself: Negative Social Network Orientation, Social Resources, and Health-Related Quality of Life in Cancer Survivors

Cancer survivors treated with hematopoietic stem cell transplant rely on their social network for successful recovery. However, some survivors have negative attitudes about using social resources (negative social network orientation) that are critical for their recovery