16,239 research outputs found
Development and verification of design methods for ducts in a space nuclear shield
A practical method for computing the effectiveness of a space nuclear shield perforated by small tubing and cavities is reported. Performed calculations use solutions for a two dimensional transport code and evaluate perturbations of that solution using last flight estimates and other kernel integration techniques. In general, perturbations are viewed as a change in source strength of scattered radiation and a change in attenuation properties of the region
The role of Facebook groups in the management and raising of awareness of antidepressant withdrawal: is social media filling the void left by health services?
Introduction: Antidepressant withdrawal is experienced by about half of people who try to reduce or come off their medication. It can be a debilitating, long lasting process. Many clinicians misdiagnose or minimise symptoms, inadvertently prolonging suffering. Most are unable to help patients safely taper off.
There has been little research into peer support communities that are playing an increasingly important role in helping people withdraw from psychiatric medications.
Method: To illustrate the growth and activities of Facebook withdrawal groups we examined thirteen such groups. All were raising awareness of, and supporting individuals tapering off, antidepressants and were followed for 13 months. A further three groups were added for the last 5 months of the study.
Results: In June 2020, the groups had a total membership of 67,125, of which, 60,261 were in private groups. The increase in membership for the 13 groups over the study period was 28.4%. One group was examined in greater detail. Group membership was 82.5% female, as were 80% of the Administrators and Moderators, all of whom are lay volunteers. Membership was international but dominated by the US (51.2%). The most common reason for seeking out this group was failed clinician-led tapers.
Discussion: The results are discussed in the context of research on the prevalence, duration and severity of antidepressant withdrawal. We question why so many patients seek help in peer-led Facebook groups, rather than relying on the clinicians that prescribed the medications. The withdrawal experiences of tens of thousands of people remain hidden in these groups where they receive support to taper when healthcare services should be responsible. Further research should focus on the methods of support and tapering protocols used in these groups to enable improved, more informed support by clinicians. Support from Governments and healthcare agencies is also needed, internationally, to address this issue
Incompressible liquid state of rapidly-rotating bosons at filling factor 3/2
Bosons in the lowest Landau level, such as rapidly-rotating cold trapped
atoms, are investigated numerically in the specially interesting case in which
the filling factor (ratio of particle number to vortex number) is 3/2. When a
moderate amount of a longer-range (e.g. dipolar) interaction is included, we
find clear evidence that the ground state is in a phase constructed earlier by
two of us, in which excitations possess non-Abelian statistics.Comment: 5 pages, 5 figure
Low-power radio galaxy environments in the Subaru/XMM-Newton Deep Field at z~0.5
We present multi-object spectroscopy of galaxies in the immediate (Mpc-scale)
environments of four low-power (L_1.4 GHz < 10^25 W/Hz) radio galaxies at
z~0.5, selected from the Subaru/XMM-Newton Deep Field. We use the spectra to
calculate velocity dispersions and central redshifts of the groups the radio
galaxies inhabit, and combined with XMM-Newton (0.3-10 keV) X-ray observations
investigate the L_X--sigma_v and T_X--sigma_v scaling relationships. All the
radio galaxies reside in moderately rich groups -- intermediate environments
between poor groups and rich clusters, with remarkably similar X-ray
properties. We concentrate our discussion on our best statistical example that
we interpret as a low-power (FRI) source triggered within a sub-group, which in
turn is interacting with a nearby group of galaxies, containing the bulk of the
X-ray emission for the system -- a basic scenario which can be compared to more
powerful radio sources at both high (z>4) and low (z<0.1) redshifts. This
suggests that galaxy-galaxy interactions triggered by group mergers may play an
important role in the life-cycle of radio galaxies at all epochs and
luminosities.Comment: 12 pages, 7 figures, accepted for publication in MNRAS. High
resolution version available upon reques
Malaria-filaria coinfection in mice makes malarial disease more severe unless filarial infection achieves patency
Coinfections are common in natural populations, and the literature suggests that helminth coinfection readily affects how the immune system manages malaria. For example, type 1–dependent control of malaria parasitemia might be impaired by the type 2 milieu of preexisting helminth infection. Alternatively, immunomodulatory effects of helminths might affect the likelihood of malarial immunopathology. Using rodent models of lymphatic filariasis (Litomosoides sigmodontis) and noncerebral malaria (clone AS Plasmodium chabaudi chabaudi), we quantified disease severity, parasitemia, and polyclonal splenic immune responses in BALB/c mice. We found that coinfected mice, particularly those that did not have microfilaremia (Mf), had more severe anemia and loss of body mass than did mice with malaria alone. Even when controlling for parasitemia, malaria was most severe in Mf coinfected mice, and this was associated with increased interferon-g responsiveness. Thus, in Mf mice, filariasis upset a delicate immunological balance in malaria infection and exacerbated malaria-induced immunopathology. Helminth infections are prevalent throughout tropical regions where malaria is transmitted [1–5]. Interactions among infections commonly alter disease severity [6, 7], and malaria-helminth coinfection can either exac
Escape path complexity and its context dependency in Pacific blue-eyes (Pseudomugil signifer)
The escape trajectories animals take following a predatory attack appear to
show high degrees of apparent 'randomness' - a property that has been described
as 'protean behaviour'. Here we present a method of quantifying the escape
trajectories of individual animals using a path complexity approach. When fish
(Pseudomugil signifer) were attacked either on their own or in groups, we find
that an individual's path rapidly increases in entropy (our measure of
complexity) following the attack. For individuals on their own, this entropy
remains elevated (indicating a more random path) for a sustained period (10
seconds) after the attack, whilst it falls more quickly for individuals in
groups. The entropy of the path is context dependent. When attacks towards
single fish come from greater distances, a fish's path shows less complexity
compared to attacks that come from short range. This context dependency effect
did not exist, however, when individuals were in groups. Nor did the path
complexity of individuals in groups depend on a fish's local density of
neighbours. We separate out the components of speed and direction changes to
determine which of these components contributes to the overall increase in path
complexity following an attack. We found that both speed and direction measures
contribute similarly to an individual's path's complexity in absolute terms.
Our work highlights the adaptive behavioural tactics that animals use to avoid
predators and also provides a novel method for quantifying the escape
trajectories of animals.Comment: 9 page
Potential solar axion signatures in X-ray observations with the XMM-Newton observatory
The soft X-ray flux produced by solar axions in the Earth's magnetic field is
evaluated in the context of ESA's XMM-Newton observatory. Recent calculations
of the scattering of axion-conversion X-rays suggest that the sunward
magnetosphere could be an observable source of 0.2-10 keV photons. For
XMM-Newton, any conversion X-ray intensity will be seasonally modulated by
virtue of the changing visibility of the sunward magnetic field region. A
simple model of the geomagnetic field is combined with the ephemeris of
XMM-Newton to predict the seasonal variation of the conversion X-ray intensity.
This model is compared with stacked XMM-Newton blank sky datasets from which
point sources have been systematically removed. Remarkably, a seasonally
varying X-ray background signal is observed. The EPIC count rates are in the
ratio of their X-ray grasps, indicating a non-instrumental, external photon
origin, with significances of 11(pn), 4(MOS1) and 5(MOS2) sigma. After
examining the constituent observations spatially, temporally and in terms of
the cosmic X-ray background, we conclude that this variable signal is
consistent with the conversion of solar axions in the Earth's magnetic field.
The spectrum is consistent with a solar axion spectrum dominated by
bremsstrahlung- and Compton-like processes, i.e. axion-electron coupling
dominates over axion-photon coupling and the peak of the axion spectrum is
below 1 keV. A value of 2.2e-22 /GeV is derived for the product of the
axion-photon and axion-electron coupling constants, for an axion mass in the
micro-eV range. Comparisons with limits derived from white dwarf cooling may
not be applicable, as these refer to axions in the 0.01 eV range. Preliminary
results are given of a search for axion-conversion X-ray lines, in particular
the predicted features due to silicon, sulphur and iron in the solar core, and
the 14.4 keV transition line from 57Fe.Comment: Accepted for publication in MNRAS. 67 pages total, including 39
figures, 6 table
What are the key issues regarding the role of geothermal energy in meeting energy needs in the global south?
Tunneling spectroscopy studies of aluminum oxide tunnel barrier layers
We report scanning tunneling microscopy and ballistic electron emission
microscopy studies of the electronic states of the uncovered and
chemisorbed-oxygen covered surface of AlOx tunnel barrier layers. These states
change when chemisorbed oxygen ions are moved into the oxide by either flood
gun electron bombardment or by thermal annealing. The former, if sufficiently
energetic, results in locally well defined conduction band onsets at ~1 V,
while the latter results in a progressively higher local conduction band onset,
exceeding 2.3 V for 500 and 600 C thermal anneals
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