Associate Editor for the Detroit Issue ...

Roll 35. Class Pix (Pictures). Image 1 of 23. (9 Febrary, 1953) [PHO 1.35.1]The Boleslaus Lukaszewski (Father Luke) Photographs contain more than 28,000 images of Saint Louis University people, activities, and events between 1951 and 1970. The photographs were taken by Boleslaus Lukaszewski (Father Luke), a Jesuit priest and member of the University's Philosophy Department faculty

Reconstruction of a model L Podbielniak fractional distillation apparatus

The purpose of this thesis was to reconstruct a Model L Podbielniak Fractional Distillation Apparatus to provide equipment suitable for the study of batch multicomponent distillation. The apparatus will also serve as an analytical instrument. The equipment was instrumented to automatically control the distillation, but an operator is needed to select fractions and insure the proper functioning of the controls. Samples of hydrocarbon mixtures of known composition were analyzed to prove the successful operation of the reconstructed apparatus --Introduction, pages 2-3

A Technical, Musical, and Historical Analysis of Frederic Chopin’s Etudes, Op. 10

While learning the etudes I decided to write a paper discussing their musical and technical challenges that would serve as a guide in working through these challenges. This guide is intended for both performers of the etudes and teachers in helping their more gifted students

DOC cycling in a temperate estuary: A mass balance approach using natural 14C and 13C isotopes

We measured dissolved organic carbon (DOC), dissolved inorganic carbon (DIC), and their corresponding D14C and d13C values in order to study the sources and fates of DOC in the York River Estuary (Virginia, U.S.A.). The D14C and d13C values of DOC and DIC at the freshwater end-member indicate that during periods of moderate to high flow, riverine DOC entering the York was composed of decadal-aged terrestrially organic matter. In nearly all cases, DOC concentrations exceeded conservative mixing lines and were therefore indicative of a net DOC input flux from within the estuary that averaged 1.2 mM L21 d21 . The nonconservative behavior of DOC in the York River Estuary was also apparent in carbon isotopic mixing curves and the application of an isotopic mixing model. The model predicted that 20–38% of the DOC at the mouth of the estuary was of riverine (terrestrial 1 freshwater) origin, while 38–56% was added internally, depending on the isotopic values assigned to the internally added DOC. Measurements of D14C and d13C of DOC and DIC and marsh organic matter suggest that the internal sources originated from estuarine phytoplankton and marshes. The isotopic mixing model also indicates a significant concomitant loss (27–45%) of riverine DOC within the estuary. Changes in DOC concentration, D14C-DOC, and d13C-DOC were also measured during incubation experiments designed to quantify the amounts, sources, and ages of DOC supporting the carbon demands of estuarine bacteria. Results of these experiments were consistent with an estuarine source of phytoplankton and marsh DOC and the preferential utilization of young (14C-enriched) DOC in the low-salinity reaches of the York. However, the average removal of riverine DOC by bacteria accounts for only ;4–19% of the riverine pool; therefore, other significant sinks for DOC exist within the estuary

Atmospheric CO2 evasion, dissolved inorganic carbon production, and net heterotrophy in the York River estuary

Direct measurements of the partial pressure of CO2 (pCO2) and dissolved inorganic carbon (DIC) were made over a 2‐yr period in surface waters of the York River estuary in Virginia. The pCO2 in surface waters exceeded that in the overlying atmosphere, indicating that the estuary was a net source of CO2 to the atmosphere at most times and locations. Salinity‐based DIC mixing curves indicate there was also an internal source of both DIC and alkalinity, implying net alkalinity generation within the estuary. The DIC and alkalinity source displayed seasonal patterns similar to that of pCO2 and were reproducible over a 2‐yr study period. We propose that the source of inorganic carbon necessary for both the sustained CO2evasion to the atmosphere and the advective export of DIC is respiration in excess of primary production (e.g., net heterotrophy). The rates of CO2 evasion and DIC export were estimated to provide an annual rate of net heterotrophy of ~100 g C m−2 yr−1. Approximately 40% of this excess inorganic carbon production was exported as DIC to the coastal ocean, whereas 60% was lost as CO2 evasion to the atmosphere. The alkalinity generation needed to sustain the export of inorganic carbon, as HCO3− , is most likely provided by net sulfate reduction in sediments. Accumulation of sulfide in the sediments of a representative site directly adjacent to the York River estuary is sufficient to account for the net export of alkalinity. The seasonality of net heterotrophy causes large variations in annual CO2 and DIC concentrations, and it stresses the need for comprehensive temporal data sets when reporting annual rates of CO2 evasion, DIC advection, and net heterotrophy

Individual heat map assessments demonstrate vestronidase alfa treatment response in a highly heterogeneous mucopolysaccharidosis VII study population.

Mucopolysaccharidosis (MPS) VII is an ultra-rare, progressively debilitating, life-threatening lysosomal disease caused by deficiency of the enzyme, β-glucuronidase. Vestronidase alfa is an approved enzyme replacement therapy for MPS VII. UX003-CL301 was a phase 3, randomized, placebo-controlled, blind-start study examining the efficacy and safety of vestronidase alfa 4 mg/kg intravenously administered every 2 weeks to 12 patients with MPS VII. Due to the rarity of disease, broad eligibility criteria resulted in a highly heterogeneous population with variable symptoms. For an integrated view of the diverse data, the changes from baseline (or randomization for the placebo period) in clinical endpoints were grouped into three functional domains (mobility, fatigue, and fine motor + self-care) and analyzed post-hoc as subject-level heat maps. Mobility assessments included the 6-minute walk test, 3-minute stair climb test, Bruininks-Oseretsky test (BOT-2) gross motor function subtests, and patient-reported outcome assessments (PROs) related to movement, pain, and ambulation. Fatigue assessments included the Pediatric Quality of Life Multidimensional Fatigue Scale and other fatigue-related PROs. Fine motor + self-care assessments included BOT-2 fine motor function subtests and PROs for eating, dressing, hygiene, and caregiver assistance. Most subjects showed improvement in at least one domain. Two subjects improved in two or more domains and two subjects did not show clear improvement in any domain. Both severely and mildly affected subjects improved with vestronidase alfa in clinical assessments, PRO results, or both. Heat map analysis demonstrates how subjects responded to treatment across multiple domains, providing a useful visual tool for studying rare diseases with variable symptoms

Domestic and international influences on attitudes toward foreign economic policy

Caption titleAt head of title: Communications"April 15, 1955.""Paper to be delivered at AAPOR meetings, Madison, Wisconsin, April 1953.""L2-377"--handwritten on leaf [1]Authors listed at end of paper read: Ithiel de Sola Pool and Raymond A. Baue