Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice

Submitted by Kamylla Nascimento ([email protected]) on 2017-11-16T13:07:55Z No. of bitstreams: 1 art. Diethylcarbamazine Reduces - rocha.pdf: 5582953 bytes, checksum: 562326c09cbcfb6e9d9e7d22e6d0890a (MD5)Approved for entry into archive by Kamylla Nascimento ([email protected]) on 2017-11-16T13:20:48Z (GMT) No. of bitstreams: 1 art. Diethylcarbamazine Reduces - rocha.pdf: 5582953 bytes, checksum: 562326c09cbcfb6e9d9e7d22e6d0890a (MD5)Made available in DSpace on 2017-11-16T13:20:48Z (GMT). No. of bitstreams: 1 art. Diethylcarbamazine Reduces - rocha.pdf: 5582953 bytes, checksum: 562326c09cbcfb6e9d9e7d22e6d0890a (MD5) Previous issue date: 2014Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.This study investigated the anti-inflammatory effects of DEC on the CCl4-induced hepatotoxicity in C57BL/6 mice. Chronic inflammation was induced by i.p. administration of CCl4 0.5 μL/g of body weight through two injections a week for 6 weeks. DEC (50 mg/kg) was administered by gavage for 12 days before finishing the CCl4 induction. Histological analyses of the DEC-treated group exhibited reduced inflammatory process and prevented liver necrosis and fibrosis. Immunohistochemical and immunofluorescence analyses of the DEC-treated group showed reduced COX-2, IL1β, MDA, TGF-β, and αSMA immunopositivity, besides exhibiting decreased IL1β, COX-2, NFκB, IFNγ, and TGFβ expressions in the western blot analysis. The DEC group enhanced significantly the IL-10 expression. The reduction of hepatic injury in the DEC-treated group was confirmed by the COX-2 and iNOS mRNA expression levels. Based on the results of the present study, DEC can be used as a potential anti-inflammatory drug for chronic hepatic inflammation

Riscos ocupacionais na legislação trabalhista brasileira: destaque para aqueles relativos à saúde e à voz do professor Occupational risks in the Brazilian labor legislation: highlight on those related to teacher's health and voice

OBJETIVO: Analisar a legislação a respeito de riscos ocupacionais, com destaque para aqueles relacionados à saúde e à voz do professor. MÉTODOS: Trata-se de pesquisa bibliográfica, de caráter qualitativo, que considerou as políticas públicas sobre Saúde e Segurança no Trabalho. As Normas Regulamentadoras foram lidas e seus conteúdos analisados e organizados por categorias, com recorte para aqueles referentes ao ambiente escolar. RESULTADOS: As 33 normas focalizam os fatores de risco, níveis de tolerância e controle para saúde e segurança no trabalho. Os agentes ambientais nocivos são múltiplos e suas especificidades, como concentração e frequência, determinam o nível de tolerância à exposição. Na escola, os riscos ambientais como ruído, poeira, temperatura e iluminação inadequadas, dentre outros, estão presentes, porém em grau leve. O tratamento acústico, de iluminação e de ventilação é indicado para controle desses riscos. Os documentos mostram situações de agravos à saúde dos trabalhadores em graus de risco muito maiores do que aqueles da docência. Não há explicitação de fatores inerentes à organização do trabalho e os cuidados com a voz limitam-se à profissão de teleoperador, o que pode servir de referência para o professor. CONCLUSÃO: A legislação trabalhista é ampla ao abarcar a diversidade de condições de trabalho e garantir a saúde dos trabalhadores. A docência apresenta riscos ocupacionais à saúde mais leves do que outras profissões; contudo, os fatores organizacionais do trabalho, assim como os distúrbios de voz, muito frequentes na docência, carecem de maior atenção da legislação no Brasil.<br>PURPOSE: To analyze the legislation regarding occupational risks, highlighting those related to teacher's health and voice. METHODS: A bibliographic search of qualitative nature regarding the public policies about Health and Security at Work was carried out. The Regulatory Standards were read and their contents analyzed and organized into categories, detaching those from the scholar environment. RESULTS: The 33 regulatory standards focus the risk factors, tolerance levels, and control for health and security at work. The harmful environmental agents are multiple and their specificities, such as concentration and frequency, determine the level of tolerance to exposition. At school, the environmental risks like noise, dust, temperature and inadequate lighting, among others, are present, however in a mild degree. The acoustic, lighting and exhaust ventilation treatments are indicated for the control of such risks. The documents show situations of worsening of the workers' health in much higher degrees of risk than those from teaching activities. There is no explicitation of factors inherent to the work organization, and the care with the voice is limited to the profession of telesales workers, which can serve as a reference to the teacher's work. CONCLUSION: Labor legislation is ample to cover the diversity of work conditions and to ensure the workers' health. Teaching presents milder occupational risks to health than other professions; nevertheless, the organizational factors of work, as well as voice disorders, very frequent in this activity, demand greater attention from Brazilian legislation

NEOTROPICAL XENARTHRANS: a data set of occurrence of xenarthran species in the Neotropics

Xenarthrans—anteaters, sloths, and armadillos—have essential functions for ecosystem maintenance, such as insect control and nutrient cycling, playing key roles as ecosystem engineers. Because of habitat loss and fragmentation, hunting pressure, and conflicts with domestic dogs, these species have been threatened locally, regionally, or even across their full distribution ranges. The Neotropics harbor 21 species of armadillos, 10 anteaters, and 6 sloths. Our data set includes the families Chlamyphoridae (13), Dasypodidae (7), Myrmecophagidae (3), Bradypodidae (4), and Megalonychidae (2). We have no occurrence data on Dasypus pilosus (Dasypodidae). Regarding Cyclopedidae, until recently, only one species was recognized, but new genetic studies have revealed that the group is represented by seven species. In this data paper, we compiled a total of 42,528 records of 31 species, represented by occurrence and quantitative data, totaling 24,847 unique georeferenced records. The geographic range is from the southern United States, Mexico, and Caribbean countries at the northern portion of the Neotropics, to the austral distribution in Argentina, Paraguay, Chile, and Uruguay. Regarding anteaters, Myrmecophaga tridactyla has the most records (n = 5,941), and Cyclopes sp. have the fewest (n = 240). The armadillo species with the most data is Dasypus novemcinctus (n = 11,588), and the fewest data are recorded for Calyptophractus retusus (n = 33). With regard to sloth species, Bradypus variegatus has the most records (n = 962), and Bradypus pygmaeus has the fewest (n = 12). Our main objective with Neotropical Xenarthrans is to make occurrence and quantitative data available to facilitate more ecological research, particularly if we integrate the xenarthran data with other data sets of Neotropical Series that will become available very soon (i.e., Neotropical Carnivores, Neotropical Invasive Mammals, and Neotropical Hunters and Dogs). Therefore, studies on trophic cascades, hunting pressure, habitat loss, fragmentation effects, species invasion, and climate change effects will be possible with the Neotropical Xenarthrans data set. Please cite this data paper when using its data in publications. We also request that researchers and teachers inform us of how they are using these data