Gender control:(Re) framing bullying, harassment and gender regulation

In the last decade, discourses of bullying and harassment have featured prominently within educational policy and administration, academic research, popular media, and public dialogue. The ways in which these have been framed has generally been consistent with an individualistic, behavioural perspective that distinctly outlines a ‘bully’ and a ‘victim’- each with specific attributes and performances. This approach arguably simplifies and reduces complex socio-cultural aspects surrounding young people and the wider communities that they are situated within, while simultaneously preventing a deconstruction of gendered, classed and racialised meanings within ‘bullying’ frameworks. This chapter proposes utilising a post-structural feminist approach to re-frame ideas of bullying and harassment as only one indicator of a wider framework of gender regulation. The role of compulsory heterosexuality and the subsequent binary expectations of femininity and masculinity in the production of this regulation will be reviewed in consideration with wider literature. In consideration of these aspects, the concept of a gender regulation framework will be examined to allow more effective exploration of violence in schools

The 3-D clustering of radio galaxies in the TONS survey

We present a clustering analysis of the Texas-Oxford NVSS Structure (TONS) radio galaxy redshift survey. This complete flux-limited survey consists of 268 radio galaxies with spectroscopic redshifts in three separate regions of the sky covering a total of 165 deg^2. By going to faint radio flux densities (s_1.4>3 mJy) but imposing relatively bright optical limits (E R 19.5), the TONS sample is optimised for looking at the clustering properties of low luminosity radio galaxies in a region of moderate (0 < z < 0.5) redshifts. We use the two point correlation function to determine the clustering strength of the combined TONS08 and TONS12 sub-samples and find a clustering strength of r_0(z)=8.7+/-1.6 Mpc (h=0.7). If we assume growth of structure by linear theory and that the median redshift is 0.3, this corresponds to r_0(0)=11.0+/-2.0 Mpc which is consistent with the clustering strength of the underlying host galaxies (~ 2.5 Lstar ellipticals) of the TONS radio galaxy population.Comment: 18 pages, MNRAS accepted. Full paper including all spectra can be found at http://www.noao.edu/noao/staff/brand/brand_corr_fn.ps.g

The Triggering and Bias of Radio Galaxies

We present new results on the clustering and three-dimensional distribution of radio galaxies from the Texas-Oxford NVSS Structure (TONS) survey. The TONS survey was constructed to look at the distribution of radio galaxies in a region of moderate (0 < z < 0.5) redshifts by matching NVSS sources with objects in APM catalogues to obtain a sample of optically bright (R < 19.5), radio faint (1.4-GHz flux density S_1.4 > 3 mJy) radio galaxies over large areas on the sky. We find that redshift spikes, which represent large concentrations of radio galaxies which trace (~ 100 Mpc^3) super-structures are a common phenomena in these surveys. Under the assumption of quasi-linear structure formation theory and a canonical radio galaxy bias, the structures represent ~ 4-5 sigma peaks in the primordial density field and their expected number is low. The most plausible explanation for these low probabilities is an increase in the radio galaxy bias with redshift. To investigate potential mechanisms which have triggered the radio activity in these galaxies - and hence may account for an increase in the bias of this population, we performed imaging studies of the cluster environment of the radio galaxies in super-structure regions. Preliminary results show that these radio galaxies may reside preferentially at the edges of rich clusters. If radio galaxies are preferentially triggered as they fall towards rich clusters then they would effectively adopt the cluster bias.Comment: 4 pages to be published in the proceedings of "Multiwavelength AGN Surveys", Cozumel, Dec 8-12, 200

Using radio galaxies to find super-structures

Radio galaxies are excellent at tracing large-scale structure due to their high bias. We present new results from the TONS08 radio galaxy redshift survey. We find unequivocal evidence for a huge (at least 80 x 80 x 100 Mpc^3) super-structure at redshift z=0.27, confirming tentative evidence for such a structure from the 7C redshift survey (7CRS). A second, newly discovered super-structure is also tentatively found at redshift 0.35 (of dimensions at least 100 x 100 x 100 Mpc^3). Out of the total sample size of 84 radio galaxies, at least 25 are associated with the two super-structures. We use quasi-linear structure formation theory to estimate the number of such structures expected in the TONS08 volume if the canonical value for radio galaxy bias is assumed. Under this assumption, the structures represent ~ 4-5 sigma peaks in the primordial density field and their expected number is low (10^{-2}-10^{-4}). Fortunately, there are several plausible explanations (many of which are testable) for these low probabilities in the form of potential mechanisms for boosting the bias on large scales. These include: the association of radio galaxies with highly biased rich clusters in super-structures, enhanced triggering by group/group mergers, and enhanced triggering and/or redshift space distortion in collapsing systems as the growth of super-structures moves into the non-linear regime. Similar structures could have been missed in previous surveys because of the effects of Poisson-sampling fluctuations.Comment: 6 pages, 3 figures. To appear in "Radio galaxies: past, present and future", eds M. Jarvis et al., Leiden, Nov 200

Spatiotemporal modelling of flood-related impacts on daily population movement

This paper presents research combining spatiotemporal population flow data, flood modelling and network analysis to examine the effect of time of flood onset and flood magnitude on travel across a city for commuters and primary school children. Findings quantify that flood onset time has an effect on the disruption to travel comparable to flood event magnitud

In Vivo Emergence of a Novel Protease Inhibitor Resistance Signature in HIV-1 Matrix.

Protease inhibitors (PIs) are the second- and last-line therapy for the majority of HIV-infected patients worldwide. Only around 20% of individuals who fail PI regimens develop major resistance mutations in protease. We sought to explore the role of mutations in gag-pro genotypic and phenotypic changes in viruses from six Nigerian patients who failed PI-based regimens without known drug resistance-associated protease mutations in order to identify novel determinants of PI resistance. Target enrichment and next-generation sequencing (NGS) with the Illumina MiSeq system were followed by haplotype reconstruction. Full-length Gag-protease gene regions were amplified from baseline (pre-PI) and virologic failure (VF) samples, sequenced, and used to construct gag-pro-pseudotyped viruses. Phylogenetic analysis was performed using maximum-likelihood methods. Susceptibility to lopinavir (LPV) and darunavir (DRV) was measured using a single-cycle replication assay. Western blotting was used to analyze Gag cleavage. In one of six participants (subtype CRF02_AG), we found 4-fold-lower LPV susceptibility in viral clones during failure of second-line treatment. A combination of four mutations (S126del, H127del, T122A, and G123E) in the p17 matrix of baseline virus generated a similar 4-fold decrease in susceptibility to LPV but not darunavir. These four amino acid changes were also able to confer LPV resistance to a subtype B Gag-protease backbone. Western blotting demonstrated significant Gag cleavage differences between sensitive and resistant isolates in the presence of drug. Resistant viruses had around 2-fold-lower infectivity than sensitive clones in the absence of drug. NGS combined with haplotype reconstruction revealed that resistant, less fit clones emerged from a minority population at baseline and thereafter persisted alongside sensitive fitter viruses. We used a multipronged genotypic and phenotypic approach to document emergence and temporal dynamics of a novel protease inhibitor resistance signature in HIV-1 matrix, revealing the interplay between Gag-associated resistance and fitness

Two 100 Mpc-scale structures in the 3-D distribution of radio galaxies and their implications

We present unequivocal evidence for a huge (~80 x 100 x 100 Mpc^3) super-structure at redshift z=0.27 in the 3-D distribution of radio galaxies from the TONS08 sample, confirming tentative evidence for such a structure from the 7C redshift survey (7CRS). A second, newly discovered super-structure is also less securely found at redshift 0.35 (of dimensions ~100 x 100 x 100 Mpc^3). We present full observational details on the TONS08 sample which was constructed to probe structures in the redshift range 0 < z < 0.5 by matching NVSS sources with objects in APM catalogues to obtain a sample of optically bright (E ~ R 3 mJy) radio galaxies in the same 25 deg^2 area as part-II of the 7CRS. Out of the total sample size of 84 radio galaxies, at least 25 are associated with the two ~100 Mpc-scale super-structures. We use quasi-linear structure formation theory to estimate the number of such structures expected in the TONS08 volume if the canonical value for radio galaxy bias is assumed. Under this assumption, the structures represent ~ 4-5 sigma peaks in the primordial density field and their expected number is low (~10^-2 - 10^-4). Fortunately, there are several plausible explanations (many of which are testable) for these low probabilities in the form of potential mechanisms for boosting the bias on large scales. These include: the association of radio galaxies with highly biased rich clusters in super-structures, enhanced triggering by group/group mergers, and enhanced triggering and/or redshift space distortion in collapsing systems as the growth of super-structures moves into the non-linear regime (abridged).Comment: Accepted for publication in MNRAS. 26 pages,16 figures. spectra can be found in: http://www-astro.physics.ox.ac.uk/~brand/08_paper.ps.g

High prevalence of integrase mutation L74I in West African HIV-1 subtypes prior to integrase inhibitor treatment.

OBJECTIVES: HIV-1 integrase inhibitors are recommended as first-line therapy by WHO, though efficacy and resistance data for non-B subtypes are limited. Two recent trials have identified the integrase L74I mutation to be associated with integrase inhibitor treatment failure in HIV-1 non-B subtypes. We sought to define the prevalence of integrase resistance mutations, including L74I, in West Africa. METHODS: We studied a Nigerian cohort of recipients prior to and during receipt of second-line PI-based therapy, who were integrase inhibitor-naive. Illumina next-generation sequencing with target enrichment was used on stored plasma samples. Drug resistance was interpreted using the Stanford Resistance Database and the IAS-USA 2019 mutation lists. RESULTS: Of 115 individuals, 59.1% harboured CRF02_AG HIV-1 and 40.9% harboured subtype G HIV-1. Four participants had major IAS-USA integrase resistance-associated mutations detected at low levels (2%-5% frequency). Two had Q148K minority variants and two had R263K (one of whom also had L74I). L74I was detected in plasma samples at over 2% frequency in 40% (46/115). Twelve (26.1%) had low-level minority variants of between 2% and 20% of the viral population sampled. The remaining 34 (73.9%) had L74I present at >20% frequency. L74I was more common among those with subtype G infection (55.3%, 26/47) than those with CRF02_AG infection (29.4%, 20/68) (P = 0.005). CONCLUSIONS: HIV-1 subtypes circulating in West Africa appear to have very low prevalence of major integrase mutations, but significant prevalence of L74I. A combination of in vitro and clinical studies is warranted to understand the potential implications.K.E.B. is supported by Wellcome Trust award number 170461. N.N. is supported by NIH R01 AI147331-01. R.K.G. is supported by a Wellcome Trust Senior Fellowship in Clinical Science (WT108082AIA). This study was supported by the President’s Emergency Plan for AIDS Relief (PEPFAR) through the Centers for Disease Control and Prevention (CDC) under the terms of U2G GH002099-01 and PA GH17-1753 (ACHIEVE)

Dust polarization in OMC-1

We present ALMA Band 7 polarization observations of the OMC-1 region of the Orion molecular cloud. We find that the polarization pattern observed in the region is likely to have been significantly altered by the radiation field of the >104 L⊙ high-mass protostar Orion Source I. In the protostar’s optically thick disc, polarization is likely to arise from dust self-scattering. In material to the south of Source I – previously identified as a region of ‘anomalous’ polarization emission – we observe a polarization geometry concentric around Source I. We demonstrate that Source I’s extreme luminosity may be sufficient to make the radiative precession time-scale shorter than the Larmor time-scale for moderately large grains (⁠>0.005−0.1μm), causing them to precess around the radiation anisotropy vector (k-RATs) rather than the magnetic field direction (B-RATs). This requires relatively unobscured emission from Source I, supporting the hypothesis that emission in this region arises from the cavity wall of the Source I outflow. This is one of the first times that evidence for k-RAT alignment has been found outside of a protostellar disc or AGB star envelope. Alternatively, the grains may remain aligned by B-RATs and trace gas infall on to the Main Ridge. Elsewhere, we largely find the magnetic field geometry to be radial around the BN/KL explosion centre, consistent with previous observations. However, in the Main Ridge, the magnetic field geometry appears to remain consistent with the larger-scale magnetic field, perhaps indicative of the ability of the dense Ridge to resist disruption by the BN/KL explosion