Epithelial tissue thickness improves optical coherence tomography's ability in detecting oral cancer

BACKGROUND OCT is a non-invasive imaging technique that enables the measurement of epithelial thickness and architectural changes, which can help in the diagnosis of pre-cancerous and cancerous lesions. The purpose of the study was to assess whether epithelial tissue thickness improves optical coherence tomography’s ability in detecting oral cancer. PATIENTS AND METHODS Surgically resected oral margins from 60 patients diagnosed with oral squamous cell carcinoma were subjected to OCT. Three OCT measurements (immediate, 1 h and 24 h post-resection) were conducted per resected tissue specimen to look at the effect of saline and formalin on the specimen and its effect on the reproducibility of the OCT. OCT was, then, used to measure the epithelial tissue thickness in cancer-free and cancer-involved margins in eight oral anatomical locations. This data was, then, combined with architectural changes data to calculate the sensitivity and specificity. RESULTS An overall of 189 cancer-free margins and 51 cancer-involved margins had their epithelial thickness measured using OCT and compared to histopathology. With regards to the validity of the OCT and histopathological measurements, epithelial thickness showed good correlation between different readings at all oral sites. With regards to the reproducibility of the OCT measurements, the mean epithelial thickness for all measurements at first (immediate) and second (1 h post-resection – saline preserved) measurements was not significantly different. Underestimation of the epithelial depth in cancer-free margins was 20 μm, while in the cancer-involved margins was 10 μm. Combining data from architectural changes and epithelial thickness, a sensitivity of 92% and a specificity of 94% was achieved. CONCLUSION Oral epithelium measurements using OCT were valid compared to those made with gold standard pathology. Measurements made using OCT was also reproducible with minor underestimation. Epithelial thickness, combined with architectural changes, led to high accuracy in differentiating between cancer-free and cancer-involved margins

Developments in Nanoparticles Enhanced Biofuels and Solar Energy in Malaysian Perspective: A Review of State of the Art

The rapid rise in global oil prices, the scarcity of petroleum sources, and environmental concerns have all created severe issues. As a result of the country's rapid expansion and financial affluence, Malaysia's energy consumption has skyrocketed. Biodiesel and solar power are currently two of the most popular alternatives to fossil fuels in Malaysia. These two types of renewable energy sources appear to be viable options because of their abundant availability together with environmental and performance competence to highly polluting and fast depleting fossil fuels. The purpose of adopting renewable technology is to expand the nation's accessibility to a reliable and secure power supply. The current review article investigates nonconventional energy sources added with nanosized metal particles called as nanomaterials including biodiesel and solar, as well as readily available renewable energy options. Concerning the nation's energy policy agenda, the sources of energy demand are also investigated. The article evaluates Malaysia's existing position in renewable energy industries, such as biodiesel and solar, as well as the impact of nanomaterials. This review article discusses biodiesel production, applications, and government policies in Malaysia, as well as biodiesel consumption and recent developments in the bioenergy sector, such as biodiesel property modifications utilizing nanoparticle additions. In addition, the current review study examines the scope of solar energy, different photovoltaic concentrators, types of solar energy harvesting systems, photovoltaic electricity potential in Malaysia, and the experimental setup of solar flat plate collectors (FPC) with nanotechnology

Patellofemoral pain syndrome (PFPS): a systematic review of anatomy and potential risk factors

Patellofemoral Pain Syndrome (PFPS), a common cause of anterior knee pain, is successfully treated in over 2/3 of patients through rehabilitation protocols designed to reduce pain and return function to the individual. Applying preventive medicine strategies, the majority of cases of PFPS may be avoided if a pre-diagnosis can be made by clinician or certified athletic trainer testing the current researched potential risk factors during a Preparticipation Screening Evaluation (PPSE). We provide a detailed and comprehensive review of the soft tissue, arterial system, and innervation to the patellofemoral joint in order to supply the clinician with the knowledge required to assess the anatomy and make recommendations to patients identified as potentially at risk. The purpose of this article is to review knee anatomy and the literature regarding potential risk factors associated with patellofemoral pain syndrome and prehabilitation strategies. A comprehensive review of knee anatomy will present the relationships of arterial collateralization, innervations, and soft tissue alignment to the possible multifactoral mechanism involved in PFPS, while attempting to advocate future use of different treatments aimed at non-soft tissue causes of PFPS

International Consensus Statement on Rhinology and Allergy: Rhinosinusitis

Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS

High-Frequency Electromagnetic Waves on Unshielded Twisted Pairs: Upper Bound on Carrier Frequency

This paper explores the behaviour of the ubiquitous twisted pairs at high frequencies and wideband excitation of twisted pairs up to 12GHz. Although there is a large quantity of papers on twisted pairs, the papers in the literature mostly focus on the sub-1GHz spectrum, where the current digital subscriber line technologies operate. Higher carrier frequencies on twisted pairs can enable the data rates required by the future communication networks; hence, the existing copper infrastructure can be utilised on the last mile complementing the fibre networks. Towards this objective, we derive analytical expression for the electromagnetic fields and characteristic equation of twisted pairs. With these derivations we show a fundamental limit on the operating frequency of twisted pairs beyond which twisted pairs start to radiate and behave like an antenna. To validate our theory through measurements, we designed a microstrip balun in order to excite the differential mode on the twisted pairs. Unlike off-the-shelf devices, this balun has a nearly linear transmission curve across 1-12GHz. This linearity allows us to detect the radiation which would not have been possible with an off-the-shelf device. At the end, we demonstrate that the standard twisted pairs used in the UK can be used up to 5GHz carrier frequency without any radiation effect and this upper-bound can be moved to higher frequencies by decreasing the twist lengths

Experimental Demonstration of Multigigabit Data Communication Using Surface Waves on Twisted-Pair Cables

The demand for higher broadband speeds is ever increasing whereas the deployment of full fibre to the premises is slower than initially predicted and remains costly. Solutions exploiting the existing, ubiquitous, copper network and increasing its capacity would be highly beneficial in the near term. One approach is to use surface wave (SW) transmission mode to transmit signals over the existing copper cabling network. We present proof-of-concept experimental SW data transmission on twisted pair cables. A surface wave launcher for low GHz carrier frequency operation is designed and optimised. Experimentally, we demonstrate data rates in excess of 12 Gb/s in a 1.15-3.25 GHz band over a 6.1 m twisted pair cable with an average bit error rate of 2.25×10-5, without coding or feedback implementation. Furthermore, higher frequency bands are tested with data rates up to 3.4 Gb/s displaying their potential for surface wave transmission. S-parameter measurements allow capacity estimations of SW data transmission on longer cable lengths using water-filling algorithms. Our calculations predict over 13 Gb/s capacity on a 100 m cable using a 3.5 GHz transmission bandwidth, this may be further extended by further increases to the bandwidth used for SW transmission